Search results for "Janus"
showing 9 items of 139 documents
A plasma protein corona enhances the biocompatibility of Au@Fe3O4 Janus particles
2015
AbstractAu@Fe3O4 Janus particles (JPs) are heteroparticles with discrete domains defined by different materials. Their tunable composition and morphology confer multimodal and versatile capabilities for use as contrast agents and drug carriers in future medicine. Au@Fe3O4 JPs have colloidal properties and surface characteristics leading to interactions with proteins in biological fluids. The resulting protein adsorption layer (“protein corona”) critically affects their interaction with living matter. Although Au@Fe3O4 JPs displayed good biocompatibility in a standardized in vitro situation, an in-depth characterization of the protein corona is of prime importance to unravel underlying mecha…
FLUMO: FLexible Underwater MOdem
2019
The last years have seen a growing interest in underwater acoustic communications because of its applications in marine research, oceanography, marine commercial operations, the offshore oil industry and defense. High-speed communication in the underwater acoustic channel has been challenging because of limited bandwidth, extended multipath, refractive properties of the medium, severe fading, rapid time variation and large Doppler shifts. In this paper, we show an implementation of a flexible Software-Defined Acoustic (SDA) underwater modem, where modulation parameters are completely tunable to optimize performance. In particular, we develop the system architecture following two key ideas. …
Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling
2015
Organ formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of Omb is the blocking of Jak/STAT signaling by repressing transcription of upd which encodes the Jak receptor ligand Unpaired.
Problem ludzkiej godności w katolickiej nauce społecznej na przykładzie myśli Franciszka Janusza Mazurka
2020
Człowiek i życie społeczne wymagają norm, do których mogą się odnosić w sposób pewny. Trendy i światopoglądy szybko się zmieniają, następują kolejno jedne po drugich. Wartością trwałą i niezmienną, na którą wskazuje Janusz Franciszek Mazurek, jest ludzka godność. Mazurek jest przedstawicielem szkoły lubelskiej, który z pojęcia godności uczynił centralny temat swojej naukowej refleksji. Jest to dla niego wartość ontyczna człowieka, która staje się normą odniesienia w ocenie wszelkich działań człowieka i względem niego. Omawiając tę problematykę, odnosi się do szerokiej perspektywy, sięgając m.in. do dokumentów międzynarodowych, myśli filozoficznej czy katolickiej nauki społecznej.
"Dżafar z Bagdadu" Janusza Makarczyka jako cenne źródło wiedzy o historii i literaturze arabskiej epoki Abbasydów
2018
This article deals with Janusz Makarczyk’s bestselling historical romance Jafar of Baghdad, first published in 1950. Makarczyk had a varied career as a journalist, travel writer of the ‘globtrotter school’, military officer, diplomat and academic; his deep involvement with the Middle East and Arab history began in the 1926 when he was sent to the Polish consulate in Jerusalem. The life of Jafar ibn Yahya provided him not only with enough material for a gripping story of love and romance but also a pretext for painting a broad canvas of historical events and personages. Addressed to younger readers, the book is didactic in the sense that it offers them basic information about Islam (e.g. the…
The Janus Face of Political Experience
2018
Arendt’s concept of experience can contribute in important ways to the contemporary debates in political and feminist theory. However, while the notion is ubiquitous in Arendt’s thinking we lack an understanding of experience as a concept, as opposed to the impact of Arendt’s personal experiences on her thought. Drawing from her notes for “Political Experiences in the Twentieth Century,” the article seeks to enrich our understanding of the Janus-faced character of political experience. It emphasizes the importance of vicariousness, and argues that experience should be understood as a process of suffering, enduring, and re-experiencing events beyond our conscious control. The article further…
Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal
2006
Endothelial NO synthase (eNOS) is the predominant enzyme responsible for vascular NO synthesis. A functional eNOS transfers electrons from NADPH to its heme center, where L-arginine is oxidized to L-citrulline and NO. Common conditions predisposing to atherosclerosis, such as hypertension, hypercholesterolemia, diabetes mellitus and smoking, are associated with enhanced production of reactive oxygen species (ROS) and reduced amounts of bioactive NO in the vessel wall. NADPH oxidases represent major sources of ROS in cardiovascular pathophysiology. NADPH oxidase-derived superoxide avidly interacts with eNOS-derived NO to form peroxynitrite (ONOO(-)), which oxidizes the essential NOS cofactor…
A Channel-Aware Adaptive Modem for Underwater Acoustic Communications
2021
Acoustic underwater channels are very challenging, because of limited bandwidth, long propagation delays, extended multipath, severe attenuation, rapid time variation and large Doppler shifts. A plethora of underwater communication techniques have been developed for dealing with such a complexity, mostly tailoring specific applications scenarios which can not be considered as one-size-fits-all solutions. Indeed, the design of environment-specific solutions is especially critical for modulations with high spectral efficiency, which are very sensitive to channel characteristics. In this paper, we design and implement a software-defined modem able to dynamically estimate the acoustic channel c…