Search results for "Jugend"

showing 10 items of 46 documents

Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder

2010

Contains fulltext : 87688.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. As prior genome-wide association studies (GWAS) have not yielded significant results, we conducted a meta-analysis of existing studies to boost statistical power. METHOD: We used data from four projects: a) the Children's Hospital of Philadelphia (CHOP); b) phase I of the International Multicenter ADHD Genetics project (IMAGE); c) phase II of IMAGE (IMAGE II); and d) the Pfizer-funded study from the…

Malemedicine.medical_specialtyCandidate geneAdolescentMedizinSocial SciencesGenome-wide association studySingle-nucleotide polymorphismPolymorphism Single NucleotideArticleGenomic disorders and inherited multi-system disorders [IGMD 3]03 medical and health sciences0302 clinical medicinePerception and Action [DCN 1]Developmental and Educational PsychologymedicineIMPUTATIONAttention deficit hyperactivity disorderddc:61Humansddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersInternational HapMap ProjectPsychiatryChildGenetic Association Studies030304 developmental biologyGenetic associationMental Health [NCEBP 9]0303 health sciencesCOMPONENTSmedicine.disease3. Good healthPREVALENCEPsychiatry and Mental healthAttention Deficit Disorder with HyperactivityMeta-analysisChild PreschoolFemalePsychologyFunctional Neurogenomics [DCN 2]030217 neurology & neurosurgeryImputation (genetics)Clinical psychologyGenome-Wide Association Study
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DSM-IV Combined Type ADHD Shows Familial Association With Sibling Trait Scores

2008

Contains fulltext : 69060.pdf (Publisher’s version ) (Closed access) Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM-IV inattentive and combined subtypes. Quantitative trait locus (QTL) approaches to linkage and association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributed throughout the population, u…

Malequantitative geneticsGenetics and epigenetic pathways of disease [NCMLS 6]Genetic Linkageattention deficit hyperactivity disorder (ADHD)GENOMEWIDE SCANMedizin2804 Cellular and Molecular NeuroscienceNeuroinformatics [DCN 3]MULTIPLE-REGRESSION ANALYSIS2738 Psychiatry and Mental Health0302 clinical medicineDIFFICULTIES QUESTIONNAIREDEFICIT-HYPERACTIVITY DISORDERTwins DizygoticPerception and Action [DCN 1]Genetics(clinical)DF analysisAssociation mappingGenetics (clinical)linkage studyGeneticseducation.field_of_studyATTENTION-DEFICIT/HYPERACTIVITY DISORDERDOPAMINE TRANSPORTER GENE10058 Department of Child and Adolescent PsychiatryDiagnostic and Statistical Manual of Mental DisordersPsychiatry and Mental healthCHILD-BEHAVIOR CHECKLISTConduct disorderRegression AnalysisFemalemedicine.symptomFunctional Neurogenomics [DCN 2]Clinical psychology2716 Genetics (clinical)Quantitative Trait LociPopulation610 Medicine & healthQuantitative trait locusBiologyImpulsivityMental health [NCEBP 9]behavioral disciplines and activitiesINDIVIDUAL-DIFFERENCESInterviews as TopicGenomic disorders and inherited multi-system disorders [IGMD 3]quantitative trait locus (QTL)03 medical and health sciencesCellular and Molecular NeuroscienceCognitive neurosciences [UMCN 3.2]mental disordersmedicineHumansSibling RelationsAttention deficit hyperactivity disorderFamilyGenetic Predisposition to Diseaseddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersSiblingeducationTWIN DATAmedicine.diseaseTwin study030227 psychiatryGenetic defects of metabolism [UMCN 5.1]Attention Deficit Disorder with HyperactivityCONDUCT DISORDER030217 neurology & neurosurgeryAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

2013

AM Vicente - Cross-Disorder Group of the Psychiatric Genomics Consortium Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in …

Netherlands Twin Register (NTR)MedizinInheritance PatternsSocial SciencesAUTISM SPECTRUM DISORDERSnosologyheritabilityCOMMON SNPS0302 clinical medicineCrohn DiseaseSCHIZOPHRENIAChildPsychiatric geneticsGenetics & HeredityMAJOR DEPRESSIVE DISORDERRISK0303 health sciencesATTENTION-DEFICIT/HYPERACTIVITY DISORDER120 000 Neuronal CoherenceMental DisordersVariantsBIPOLAR DISORDERASSOCIATIONGenomic disorders and inherited multi-system disorders [DCN PAC - Perception action and control IGMD 3]Psychiatric DisordersCROHNS-DISEASE3. Good healthSchizophreniagenetic association studyMedical geneticsMajor depressive disorderSNPsAdultmedicine.medical_specialtygenetic etiologymedical geneticsDEFICIT HYPERACTIVITY DISORDERBiologyPolymorphism Single Nucleotidebehavioral disciplines and activitiesArticleGenomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3]HeritabilityGenetic Heterogeneity03 medical and health sciencesPrevalence of mental disordersmental disorders/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyGeneticsmedicineddc:61HumansAttention deficit hyperactivity disorderGenetic Predisposition to Disease[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyDCN PAC - Perception action and control NCEBP 9 - Mental healthddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersBipolar disorderPsychiatry030304 developmental biologyDepressive Disorder MajorGenome HumanGenetic heterogeneitymedicine.diseaseschizophreniaAttention Deficit Disorder with HyperactivityChild Development Disorders PervasivePerturbações do Desenvolvimento Infantil e Saúde Mental030217 neurology & neurosurgeryGenome-Wide Association Study
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Noziedzīgās tieksmes un ārējie apstākļi kā noziedzīgās jaunatnes rašanās cēloņi: diplomdarbs

1937

Noziedzības cēloņiKriminālpsiholoģijaKrimināltiesībasKriminalpsychologieNoziedzībaKriminālnoziegumu sodāmībaJugend KriminelleNepilngadīgie likumpārkāpējiYouth criminals:LAW/JURISPRUDENCE::Criminal law [Research Subject Categories]
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Generation Z and Organizational Listening on Social Media

2020

Young people are avid users of social media and have appeared as a powerful force for social change, as shown by the ranks of those who have joined Greta Thunberg in the global climate movement. In addition to challenging political institutions and governments, young people today are also holding the corporate world accountable. To respond to young people’s expectations, brands, and organizations have turned to social media to interact and build relationships with them. However, critics have lamented that these attempts often fail and that young people’s trust in institutions, brands, and organizations continues to decline. This article asks how young people perceive organizational listenin…

OrganisationenGroßbritannienddc:070lcsh:Communication. Mass media0508 media and communicationsSoziale MedienInformationsverhaltenSociologyFinlandgeneration Zmedia_commonWirkungsforschung RezipientenforschungCommunication05 social sciencesJugendlicherGreat BritainPublic relationslcsh:P87-96bränditconfidenceVertrauenNutzungGlobal climatemedia_common.quotation_subjectsocial mediautilizationsosiaalinen media050801 communication & media studiesImpact Research Recipient ResearchPoliticsInteractive electronic Mediabrandsinformation-seeking behaviorPerception0502 economics and businesstrademarkgeneration Z; organizational listeningActive listeningSocial mediainteraktive elektronische MedienNews media journalism publishingorganizationsbusiness.industrySocial changetrustFinnlandadolescentMarkePublizistische Medien JournalismusVerlagswesenz-sukupolvibusinessgeneration z050203 business & managementorganizational listening
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Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicenter ADHD genetics (IMAGE…

2008

Contains fulltext : 71540.pdf (Publisher’s version ) (Closed access) There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested…

ParentsCandidate geneGenetics and epigenetic pathways of disease [NCMLS 6]2804 Cellular and Molecular NeuroscienceMedizinNeuroinformatics [DCN 3]Linkage Disequilibrium2738 Psychiatry and Mental Health0302 clinical medicineRisk FactorsPerception and Action [DCN 1]Genetics(clinical)Genetics (clinical)0303 health sciencesTPH210058 Department of Child and Adolescent PsychiatryPsychiatry and Mental healthData Interpretation StatisticalFunctional Neurogenomics [DCN 2]Clinical psychologyGenetic Markers2716 Genetics (clinical)Single-nucleotide polymorphism610 Medicine & healthMental health [NCEBP 9]Polymorphism Single NucleotideGenetic determinismGenomic disorders and inherited multi-system disorders [IGMD 3]Molecular epidemiology [NCEBP 1]03 medical and health sciencesCellular and Molecular NeuroscienceCognitive neurosciences [UMCN 3.2]Translational research [ONCOL 3]medicineAttention deficit hyperactivity disorderHumansFamilyGenetic Predisposition to Diseaseddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersAlleleAlleles030304 developmental biologyChi-Square DistributionEndocrinology and reproduction [UMCN 5.2]business.industrymedicine.diseaseGenetic defects of metabolism [UMCN 5.1]Multicenter studyAttention Deficit Disorder with HyperactivityEtiologybusiness030217 neurology & neurosurgeryAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
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Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other…

2008

Contains fulltext : 69677.pdf (Publisher’s version ) (Closed access) A major goal of genetic studies of attention deficit hyperactivity disorder (ADHD) is to identify individual characteristics that might help segregate the disorder's inherent heterogeneity. [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] recently reported a potentially important association between two dopamine-related risk polymorphisms (DRD4 variable number tandem repeat (VNTR) in exon 3 and DAT1 VNTR in the 3' UTR) and lowered IQ in ADHD. The objective of the current study was to replicate the [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] findings in a clinical sample and to extend the analysis to a large ra…

ProbandMaleGenetics and epigenetic pathways of disease [NCMLS 6]Intelligence2804 Cellular and Molecular NeuroscienceMedizinNeuroinformatics [DCN 3]Receptors DopamineCohort Studies2738 Psychiatry and Mental Health0302 clinical medicineRisk FactorsPerception and Action [DCN 1]MedicineGenetics(clinical)ChildGenetics (clinical)10058 Department of Child and Adolescent Psychiatry3. Good healthVariable number tandem repeatPsychiatry and Mental healthChild PreschoolFemaleFunctional Neurogenomics [DCN 2]Clinical psychology2716 Genetics (clinical)AdolescentGenotypeSingle-nucleotide polymorphism610 Medicine & healthMental health [NCEBP 9]Genomic disorders and inherited multi-system disorders [IGMD 3]03 medical and health sciencesCellular and Molecular NeuroscienceCognitive neurosciences [UMCN 3.2]mental disordersAttention deficit hyperactivity disorderHumansGenetic Predisposition to Diseaseddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersAlleleRisk factorAssociation (psychology)AllelesDopamine Plasma Membrane Transport Proteinsbusiness.industrymedicine.disease030227 psychiatryGenetic defects of metabolism [UMCN 5.1]Genetic markerAttention Deficit Disorder with Hyperactivitybusiness030217 neurology & neurosurgery
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Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD

2008

Contains fulltext : 70183.pdf (Publisher’s version ) (Closed access) Previous studies have found heterogeneous association between DAT1-3'-UTR-VNTR and attention deficit hyperactivity disorder (ADHD). Various proportions of conduct disorder (CD) comorbidity in their ADHD samples may partially explain the observational discrepancies. Evidence for this comes from family and twin studies which found ADHD probands with CD (ADHD + CD) are genetically different from those without CD (ADHD - CD). Genotypes of 20 DAT1 markers were analyzed in 576 trios, consisting of 141 ADHD + CD and 435 ADHD - CD. In addition to the classical TDT test, a specific genetic heterogeneity test was performed to identi…

ProbandMaleLinkage disequilibriumGenetics and epigenetic pathways of disease [NCMLS 6]2804 Cellular and Molecular NeuroscienceMedizinComorbidityNeuroinformatics [DCN 3]Linkage Disequilibrium2738 Psychiatry and Mental Health0302 clinical medicineGene FrequencyPerception and Action [DCN 1]Genetics(clinical)ChildGenetics (clinical)GeneticsIncidence10058 Department of Child and Adolescent PsychiatryEuropePsychiatry and Mental healthConduct disorder/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemaleFunctional Neurogenomics [DCN 2]Conduct DisorderGenetic Markers2716 Genetics (clinical)GenotypeSingle-nucleotide polymorphism610 Medicine & healthBiologyMental health [NCEBP 9]Polymorphism Single Nucleotidebehavioral disciplines and activitiesGenomic disorders and inherited multi-system disorders [IGMD 3]03 medical and health sciencesGenetic HeterogeneityCellular and Molecular NeuroscienceCognitive neurosciences [UMCN 3.2]SDG 3 - Good Health and Well-beingmental disordersmedicineAttention deficit hyperactivity disorderHumansddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersAlleleAllelesDopamine Plasma Membrane Transport ProteinsChi-Square DistributionGenetic heterogeneitymedicine.diseaseTwin study030227 psychiatryGenetic defects of metabolism [UMCN 5.1]HaplotypesAttention Deficit Disorder with Hyperactivity030217 neurology & neurosurgery
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The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligen…

2011

Contains fulltext : 97437.pdf (Publisher’s version ) (Open Access) BACKGROUND: The International Multi-centre ADHD Genetics (IMAGE) project with 11 participating centres from 7 European countries and Israel has collected a large behavioural and genetic database for present and future research. Behavioural data were collected from 1068 probands with ADHD and 1446 unselected siblings. The aim was to describe and analyse questionnaire data and IQ measures from all probands and siblings. In particular, to investigate the influence of age, gender, family status (proband vs. sibling), informant, and centres on sample homogeneity in psychopathological measures. METHODS: Conners' Questionnaires, St…

ProbandResearch designMale110 012 Social cognition of verbal communicationIntelligencePerception and Actions Mental Health [DCN 1]MedizinSocial Sciencescentre effectsDevelopmental psychology2738 Psychiatry and Mental Health0302 clinical medicinelcsh:PsychiatryMulticenter Studies as Topicsibling designChildATTENTION-DEFICIT/HYPERACTIVITY DISORDERMental DisordersWechsler ScalesWechsler Adult Intelligence Scale10058 Department of Child and Adolescent PsychiatryDiagnostic and Statistical Manual of Mental DisordersPsychiatry and Mental healthPhenotypeConduct disorderResearch DesignRELIABILITYFemaleFamily RelationsPsychologyClinical psychologyPsychopathologyResearch ArticleAdultlcsh:RC435-571DEFICIT HYPERACTIVITY DISORDERTWIN610610 Medicine & health150 000 MR Techniques in Brain Function03 medical and health sciencesmulti-centre studyADHD multi-centre studymedicineCriterion validityAttention deficit hyperactivity disorderHumansADHDGenetic Predisposition to Diseaseddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersSiblingMETAANALYSISFamily HealthPsychiatric Status Rating ScalesCHILD PSYCHIATRIC-PATIENTSSiblingsPARENTmedicine.disease030227 psychiatryAttention Deficit Disorder with HyperactivityCONDUCT DISORDERCRITERION VALIDITY030217 neurology & neurosurgery
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The impact of study design and diagnostic approach in a large multi-centre ADHD study. Part 1: ADHD symptom patterns

2011

Contains fulltext : 96439.pdf (Publisher’s version ) (Open Access) BACKGROUND: The International Multi-centre ADHD Genetics (IMAGE) project with 11 participating centres from 7 European countries and Israel has collected a large behavioural and genetic database for present and future research. Behavioural data were collected from 1068 probands with the combined type of attention deficit/hyperactivity disorder (ADHD-CT) and 1446 'unselected' siblings. The aim was to analyse the IMAGE sample with respect to demographic features (gender, age, family status, and recruiting centres) and psychopathological characteristics (diagnostic subtype, symptom frequencies, age at symptom detection, and com…

QuestionnairesMaleParentsResearch design110 012 Social cognition of verbal communicationPsychometricsPerception and Actions Mental Health [DCN 1]MedizinSocial Sciencescentre effects2738 Psychiatry and Mental Health0302 clinical medicinelcsh:PsychiatrySurveys and QuestionnairesTRANSPORTER GENEQTL LINKAGEsibling designChild10. No inequalityIntelligence TestsIntelligence quotientAge Factors10058 Department of Child and Adolescent PsychiatryATTENTION-DEFICIT/HYPERACTIVITY-DISORDERDiagnostic and Statistical Manual of Mental DisordersEuropePsychiatry and Mental healthResearch DesignConduct disorderFemalePsychologyResearch ArticlePsychopathologymedicine.medical_specialtyPsychometricslcsh:RC435-571DEFICIT HYPERACTIVITY DISORDER610 Medicine & health150 000 MR Techniques in Brain Functionmulti-centre study03 medical and health sciencesSex FactorsADHD multi-centre studymedicineHumansADHDAttention deficit hyperactivity disorderddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersGENOME-WIDE ASSOCIATIONSiblingPsychiatryPsychiatric Status Rating ScalesSiblingsmedicine.disease030227 psychiatryQUANTITATIVE TRAITAttention Deficit Disorder with HyperactivitySample size determinationCONDUCT DISORDERPSYCHIATRIC COMORBIDITYFOLLOW-UPinformant effectsSCAN030217 neurology & neurosurgery
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