Search results for "KF"

Evolution of Cooperation Patterns in Psoriasis Research: Co-Authorship Network Analysis of Papers in Medline (1942–2013)

2015

BackgroundAlthough researchers have worked in collaboration since the origins of modern science and the publication of the first scientific journals in the eighteenth century, this phenomenon has acquired exceptional importance in the last several decades. Since the mid-twentieth century, new knowledge has been generated from within an ever-growing network of investigators, working cooperatively in research groups across countries and institutions. Cooperation is a crucial determinant of academic success.ObjectiveThe aim of the present paper is to analyze the evolution of scientific collaboration at the micro level, with regard to the scientific production generated on psoriasis research.Me…

IT Solutions for Business Process Management

2018

In the paper are listed the main types of architectures of systems for business process management. Thus, we can identify several categories of such architectures, namely architectures of workflow management systems, flexible workflow management architectures, service-oriented architecture, advanced service composition, and data-driven approaches. As such, there are two of the five categories, namely architectures of workflow management systems and architectures of flexible workflow management systems, and a methodology is proposed for developing solutions for business process management.

Gene Set to Diseases (GS2D): disease enrichment analysis on human gene sets with literature data

2016

Large sets of candidate genes derived from high-throughput biological experiments can be characterized by functional enrichment analysis. The analysis consists of comparing the functions of one gene set against that of a background gene set. Then, functions related to a significant number of genes in the gene set are expected to be relevant. Web tools offering disease enrichment analysis on gene sets are often based on gene-disease associations from manually curated or experimental data that is accurate but does not cover all diseases discussed in the literature. Using associations automatically derived from literature data could be a cost effective method to improve the coverage of disease…

Actionable Molecular Targets in Cancer Liquid Biopsy

2017

The possibility to detect nucleic acid sequences in the bloodstream deriving from an underlying tumor process has disclosed a unique opportunity in medical oncology. Whether the nucleic acid material is leaked in the blood at any step of cancer development (circulating tumor DNA or ctDNA) or it is obtained from isolated circulating tumor cells (CTCs), the detection and analysis of the meaningful sequence defects harbored in instrumental molecular targets (which we call liquid biopsy) constitutes an invaluable tool toward leading the current oncology practice toward a less invasive and fully personalized diagnostic-therapeutic workflow. In spite of the current technical limitations that liqu…

Gender representation in authorship in later-phase systemic clinical trials in biliary tract cancer (BTC).

2021

348 Background: The proportion of females in medicine is increasing (approx. 50% in medical school/workforce), but disparities in female authorship in oncology research publications exist; female corresponding authorship reportedly ranges from 7.2-39.1% in oncology clinical trials (Ludmir et al 2019). This study aimed to describe and assess factors associated with female first and senior authorship in later phase systemic clinical trials in BTC and to identify any changes over time. Methods: Embase/Medline were used to identify final primary trial publications in BTC (2000-2020) (excluding phase I (PI) (expected to move to later phase), mixed tumour site trials, reviews, editorials and tri…

Pulmonologists, Mechanical Ventilation and Complementary Techniques

2014

Why do Norwegian nurses leave the public health service to practice CAM?

2009

Accepted version of an article published in Complementary Therapies in Clinical Practice, 15 (2009), 147-151 This paper explores a number of issues associated with the recent increase in nurses choosing to leave the Norwegian health care system in order to become independent practitioners of complementary and alternative medicine (CAM). The paper suggests that in Norway, nurses perceive medical hegemony continues to persist. Nurses perceive restrictions in their ability to develop their professional roles and status. CAM would appear to offer many nurses, the opportunity to develop their clinical skills in an autonomous, egalitarian and more holistic environment.

Towards More Sustainable Pavement Management Practices Using Embedded Sensor Technologies

2019

Road agencies are constantly being placed in difficult situations when making road maintenance and rehabilitation decisions as a result of diminishing road budgets and mounting environmental concerns for any chosen strategies. This has led practitioners to seek out new alternative and innovative ways of monitoring road conditions and planning maintenance routines. This paper considers the use of innovative piezo-floating gate (PFG) sensors and conventional strain gauges to continuously monitor the pavement condition and subsequently trigger maintenance activities. These technologies can help develop optimized maintenance strategies as opposed to traditional ad-hoc approaches, which often le…

PVAmpliconFinder: a workflow for the identification of human papillomaviruses from high-throughput amplicon sequencing

2019

Abstract Background The detection of known human papillomaviruses (PVs) from targeted wet-lab approaches has traditionally used PCR-based methods coupled with Sanger sequencing. With the introduction of next-generation sequencing (NGS), these approaches can be revisited to integrate the sequencing power of NGS. Although computational tools have been developed for metagenomic approaches to search for known or novel viruses in NGS data, no appropriate tool is available for the classification and identification of novel viral sequences from data produced by amplicon-based methods. Results We have developed PVAmpliconFinder, a data analysis workflow designed to rapidly identify and classify kno…

Recent advances of HCI in decision-making tasks for optimized clinical workflows and precision medicine.

2020

The ever-increasing amount of biomedical data is enabling new large-scale studies, even though ad hoc computational solutions are required. The most recent Machine Learning (ML) and Artificial Intelligence (AI) techniques have been achieving outstanding performance and an important impact in clinical research, aiming at precision medicine, as well as improving healthcare workflows. However, the inherent heterogeneity and uncertainty in the healthcare information sources pose new compelling challenges for clinicians in their decision-making tasks. Only the proper combination of AI and human intelligence capabilities, by explicitly taking into account effective and safe interaction paradigms,…