Search results for "KIR"

S2-lukija tulkitsijana selkomukautetun kaunokirjallisuuden lukupiirissä

2020

This article discusses reading circles of adult Finnish as a second language (L2) readers. The books that were read and discussed in the circles were easy-to-read fiction. The study focuses on how the readers interpret what they read and what kind of support they need for their interpretations. The analysis utilizes the concept of scaffolding, used in socio-cultural learning theory. The readers’ reading stances vary from what is literally said in the text to creating their own interpretations of the hidden meanings of the text. The latter are not very common in the reading circles, although many participants express a wish to create and discuss interpretations too. The analysis shows that i…

Reconfigurations in sustainability transitions : a systematic and critical review

2021

Two streams of literature have become especially prominent in understanding social change toward sustainability within the past decades: the research on socio-technical transitions and applications of social practice theory. The aim of this article is to contribute to efforts to create dialogue between these two approaches. We do this by focusing on the concept of reconfiguration, which has become a much-used, but poorly defined notion in the discussion on sustainability transitions. To understand what is defined as reconfiguration in systems and practices, and how the understanding of reconfiguration in regimes could benefit from insights about reconfiguration in practices, we conducted a …

Ecotoxicity of sediments in rivers: Invertebrate community, toxicity bioassays and the toxic unit approach as complementary assessment tools

2015

The determination of the real toxicity of sediments in aquatic ecosystems is challenging and necessary for an appropriate risk assessment. Different approaches have been developed and applied over the last several decades. Currently, the joint implementation of chemical, ecological and toxicological tools is recommended for an appropriate and successful toxicity risk assessment. We chose the combination of the toxic unit approach with acute pore water tests (Vibrio fischeri, Pseudokirchneriella subcapitata and Daphnia magna) and whole-sediment exposure tests (V. fischeri, Chironomus riparius), together with invertebrate community composition (multivariate analyses) to detect short and long-…

Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activatio…

1999

To test the Kirsten-Ras (Ki-Ras) alternative prenylation hypothesis in malignant transformation, we used a novel farnesyltransferase inhibitor competitive to farnesyl-pyrophosphate, RPR130401, and a CaaX peptidomimetic geranylgeranyltransferase-1 inhibitor GGTI-298. In Ki-Ras-overexpressing transformed adrenocortical cells, RPR130401 at 1-10 microM inhibited very efficiently the [(3)H]farnesyl but not [(3)H]geranylgeranyl transfer to Ras. However, proliferation of these cells was only slightly sensitive to RPR130401 (IC(50)=30 microM). GGTI-298 inhibited the growth of these cells with an IC(50) of 11 microM but cell lysis was observed at 15 microM. The combination of 10 microM RPR130401 and…

Transitioning from adolescence to adulthood for young people living with cerebral palsy : a meta-ethnography

2020

Transitioning from adolescence to adulthood appears to be a challenging period for young people living with cerebral palsy. The aim of this review was to highlight the challenges that might be experienced during this period. A systematic search of the literature and meta-ethnographic review examined seven qualitative research papers providing a detailed synthesis in the form of three domains summarised as ‘meaningful preparation for transition’, ‘becoming empowered’, and, ‘overcoming vulnerability’. These inform a discussion which shows that adolescents living with cerebral palsy are not prepared adequately for adult life. Examination of the literature stimulates curiosity as to the nature …

Association between developmental coordination disorder or low motor competence, and risk of impaired bone health across the lifespan: protocol for a…

2020

OBJECTIVE: This systematic review will assess the association between developmental coordination disorder and low motor competence, and impairments in bone health across the lifespan. INTRODUCTION: Individuals with developmental coordination disorder tend to have a pattern of physical activity associated with bone health impairments. Preliminary studies have found impairments in bone health measures, including fractures, throughout the lifespan with potential public health ramifications. As studies in this area are of small samples across wide age ranges no comprehensive picture of bone health in this group has been formed, hindering action. A systematic review is needed to determine the po…

La Chiesa Madre a Gibellina. Quarant'anni dal progetto alla realizzazione

2013

I quarant’anni trascorsi tra il progetto della Chiesa Madre di Gibellina e la sua consacrazione ai Santi Diego e Scolastica hanno trasformato l’architettura di Ludovico Quaroni e Luisa Anversa in un osservatorio privilegiato per poter valutare il dibattito contemporaneo sulle città di nuova fondazione e sulle chiese. La Chiesa Madre è un’architettura dal significato urbano esemplare, che, al tempo stesso, ha generato alcune perplessità in merito ai suoi aspetti liturgici. Infatti, sembra che Ludovico Quaroni, noto architetto di chiese, abbia proposto, a Gibellina, una sintesi fra arte, architettura e urbanistica rivolgendosi più a tutti i cittadini universalmente, che non alle specificità d…

Maailmanpolitiikasta gramscilaisittain

2012

Increased ventilation by fish leads to a higher risk of parasitism

2014

Background: Fish are common intermediate hosts of trematode cercariae and their gills can potentially serve as important sites of penetration by these larval stages. We experimentally tested the hypothesis that volume of ventilation flow across the gills contributes to acquisition of these parasites by fish. We manipulated the intensity of ventilation by using different oxygen concentrations. Methods: Juvenile Oncorhynchus mykiss were individually exposed for 10 minutes to a standard dose of Diplostomum pseudospathaceum cercariae at three levels of oxygen concentration, 30, 60 and 90%. Ventilation amplitude (measured as a distance between left and right operculum), operculum beat rate, and …

A mobile game as a support tool for children with severe difficulties in reading and spelling

2020

We used a randomized controlled trial to investigate if a mobile game, GraphoLearn (GL), could effectively support the learning of first graders (N = 70), who have severe difficulties in reading and spelling. We studied the effects of two versions of the game: GL Reading, which focused on training letter-sound correspondence and word reading; and GL Spelling, which included additional training in phonological skills and spelling. During the spring of first grade, the children trained with tablet computers which they could carry with them during the six-week intervention. The average exposure time to training was 5 hr 44 min. The results revealed no differences in the development of reading …