Search results for "Keratoacanthoma"
showing 10 items of 10 documents
CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma.
2015
CD1a is involved in presentation to the immune system of lipid antigen derived from tumor cells with subsequent T cell activation. Hsp60 is a molecular chaperone implicated in carcinogenesis by, for instance, modulating the immune reaction against the tumor. We have previously postulated a synergism between CD1a and Hsp60 as a key factor in the activation of an effective antitumor immune response in squamous epithelia. Keratoacantomas (KAs) are benign tumors that however can transform into squamous cell carcinomas (SCCs), but the reasons for this malignization are unknown. In a previous study, we found that CD1a-positive cells are significantly more numerous in KA than in SCC. In this study…
Glut-1 Expression and In Situ CD1a/CD57 Immunologic Deficit in Keratoacanthoma and Squamous Cell Carcinoma of Immunocompetent Patients
2011
It is not easy to reach a differential diagnosis between keratoacanthoma (KA) and squamous cell carcinoma (SCC) and furthermore there is still considerable discussion about the relationship of these 2 tumors with immunity. To facilitate such a diagnosis, we assessed the Glut-1 antibody, reported to be strongly and diffusely expressed in SCC but never assessed in KA. We studied 43 lesions of immunocompetent patients: 17 SCCs, 13 typical KAs (tKAs), and 13 atypical KAs (aKAs), with histologic features of SCC in less than 30% of the lesions. In tKA, Glut-1 stained only the basal layers of the squamous nests (basal pattern) whereas in SCC the squamous nests were randomly and diffusely stained (…
Zur Histogenese des Epithelioma Malherbe und von seinen topischen Beziehungen zum Keratoakanthom
1965
Ausgehend von der Beobachtung Keratoakanthom-artiger Strukturanteile bei einem Epithelioma Malherbe und der Feststellung von “Schattenzellfeldern” bei einem von 20 daraufhin durchgemusterten Keratoakanthomen wird zur Histogenese der Malherbeschen Geschwulstform Stellung genommen, als deren Ausgangspunkt indifferent gebliebene Zellschichten der auseren Haarwurzelscheide unterhalb der Talgdruse—im Gegensatz zu dem Ursprung des Keratoakanthoms oberhalb der Talgdruseneinmundung — angesprochen werden. Trotz dieser topischen Nachbarschaftsbeziehungen zwischen Epithelioma Malherbe und Keratoakanthom handelt es sich bei beiden Epitheliomen um zwei im Endergebnis der Geschwulstentwicklung durchaus d…
KA and SCC: GLUT1, CD1a, and CD57 different expression
2011
Solitary keratoacanthoma involving upper lip: a diagnostic dilemma - case report and a brief review
2010
Keratoacanthoma (KA) is a benign epithelial proliferative lesion which frequently occurs on the sun exposed areas of the skin. KA originates within the pilosebaceous apparatus of the skin and may be solitary or multiple. Solitary KA can be difficult to differentiate from squamous cell carcinoma (SCC) both clinically and microscopically. However, the clinical course of the lesion and its ability to self involute makes it a distinct clinical entity. Solitary KA appears on the vermilion border of the lower lips with some frequency. A case of keratoacanthoma involving the upper lip is reported presenting as an exophytic growth that resolved after excisional biopsy. Photo- graphic documentation …
Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk
2014
A fundamental goal in cancer biology is to identify the cells and signalling pathways that are keys to induce tumour regression. Here we use a spontaneously self-regressing tumour, cutaneous keratoacanthoma (KAs), to identify physiological mechanisms that drive tumour regression. By using a mouse model system that recapitulates the behaviour of human KAs, we show that self-regressing tumours shift their balance to a differentiation programme during regression. Furthermore, we demonstrate that developmental programs utilized for skin hair follicle regeneration, such as Wnt, are hijacked to sustain tumour growth and that the retinoic acid (RA) signalling pathway promotes tumour regression by …
Ecthyma- und Keratoakanthom-�hnliche eosinophile Granulome der Haut
1967
Mitteilung einer Beobachtung rezidivierender Ecthyma-und Keratoakanthom-ahnlicher Hautveranderungen bei einem ansonsten gesunden 69 jahrigen Mann, denen histologisch — am Hohepunkt der feingeweblichen Entwicklung — reticulo-histiocytar differenzierte Granulome mit massenhaft Eosinophilen und chronisch-entzundlicher Begleitinfiltration zugrunde lagen. Nach einem Uberblick uber die Entstehung des vieldeutigen Begriffes “eosinophiles Granulom der Haut” wird — gestutzt auf die einschlagige Literatur — unter Berucksichtigung klinischer, histologischer und nosologischer Faktoren eine Einteilung der “eosinophilen Granulome der Haut” in drei Gruppen vorgeschlagen und der beobachtete Fall der zweife…
Keratoacanthoma Centrifugum Marginatum (KCM) after photodynamic therapy with good response to oral retinoids and topical 5‐fluorouracil
2019
Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA), characterized by progressive peripheral growth, and usually devoid of deep invasion. Different systemic (oral retinoids) or topical treatments have been reported, but there is not a well-defined therapeutic protocol. We report the case of a KCM developing after photodynamic therapy (PDT) on the right leg of a 64-year-old woman. It was treated successfully with oral acitretin combined with topical 5-Fluorouracil + salicylic acid for 5 months. This is the first case of KCM developing after PDT and successfully treated with oral retinoid combined with topical treatment.
Centrifugal necrotic keratoacanthoma
2007
Centrifugal necrotic keratoacanthoma is a quite rare variant of keratoacanthoma, with a locally aggressive behavior and no tendency to spontaneous involution. We report a typical case of the nasal-orbital region. Based on its clinical, histological and behavioral picture, centrifugal necrotic keratoacanthoma appears as variant of giant keratoacanthoma and can be regarded as an intermediate form in a spectrum where keratoacanthoma and overt squamous cell carcinoma represent the most benign and the most malignant end, respectively, as also highlighted by analogies between the two lesions recently reported in the field of molecular biology.