6533b7d9fe1ef96bd126c4be

RESEARCH PRODUCT

Keratoacanthoma Centrifugum Marginatum (KCM) after photodynamic therapy with good response to oral retinoids and topical 5‐fluorouracil

Carlos MonteagudoAndrea EstébanezJosé M. MartínEsmeralda SilvaEncarnación Montesinos

subject

Keratoacanthomamedicine.medical_specialtymedicine.medical_treatmentAdministration OralTopical treatmentPhotodynamic therapyDermatologyAdministration CutaneousAcitretinRetinoids030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicinemedicineHumansbusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseDermatologyAcitretinKeratoacanthomaTreatment OutcomePhotochemotherapyFluorouracil030220 oncology & carcinogenesisFemaleDermatologic AgentsFluorouracilbusinessOral retinoidmedicine.drug

description

Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA), characterized by progressive peripheral growth, and usually devoid of deep invasion. Different systemic (oral retinoids) or topical treatments have been reported, but there is not a well-defined therapeutic protocol. We report the case of a KCM developing after photodynamic therapy (PDT) on the right leg of a 64-year-old woman. It was treated successfully with oral acitretin combined with topical 5-Fluorouracil + salicylic acid for 5 months. This is the first case of KCM developing after PDT and successfully treated with oral retinoid combined with topical treatment.

yearjournalcountryeditionlanguage
2019-05-12Dermatologic Therapy
https://doi.org/10.1111/dth.12988