Search results for "Keyword"
showing 10 items of 404 documents
Measurement of the permanent electric dipole moment of the neutron
2020
We present the result of an experiment to measure the electric dipole moment (EDM) of the neutron at the Paul Scherrer Institute using Ramsey’s method of separated oscillating magnetic fields with ultracold neutrons. Our measurement stands in the long history of EDM experiments probing physics violating time-reversal invariance. The salient features of this experiment were the use of a 199Hg comagnetometer and an array of optically pumped cesium vapor magnetometers to cancel and correct for magnetic-field changes. The statistical analysis was performed on blinded datasets by two separate groups, while the estimation of systematic effects profited from an unprecedented knowledge of the magne…
SWIFT J1756.9-2508: spectral and timing properties of its 2018 outburst
2018
We discuss the spectral and timing properties of the accreting millisecond X-ray pulsar SWIFT J1756.9-2508 observed by XMM-Newton, NICER and NuSTAR during the X-ray outburst occurred in April 2018. The spectral properties of the source are consistent with a hard state dominated at high energies by a non-thermal power-law component with a cut-off at ~70 keV. No evidence of iron emission lines or reflection humps has been found. From the coherent timing analysis of the pulse profiles, we derived an updated set of orbital ephemerides. Combining the parameters measured from the three outbursts shown by the source in the last ~11 years, we investigated the secular evolution of the spin frequency…
A new method for the labelling of proteins with radioactive arsenic isotopes
2006
Abstract Radioarsenic labelled radiopharmaceuticals could be a valuable asset to positron emission tomography. In particular, the long half-lives of 72As ( T 1 / 2 = 26 h ) and 74As ( T 1 / 2 = 17.8 d ) allow to investigate slow physiological or metabolical processes, like the enrichment and distribution of monoclonal antibodies (mab) in tumour tissue. In this work, a new method for the labelling of proteins with various radioactive arsenic isotopes was developed. For this purpose, two proteins, namely a chimeric IgG3 monoclonal antibody, ch3G4, directed against anionic phospholipids, and Rituxan (Rituximab), were labelled as a proof of principle with no-carrier-added radioarsenic isotopes…
Discrimination of LINAC photon and sunlight contributions in watch glass analyzed by means of thermoluminescence
2012
Abstract The research described in this paper shows how to extract from the glow curves of watch glasses exposed to LINAC photons and sunlight a contribution sensitive to LINAC photons dose. As first step, the dependence of the TL signal due to sunlight on the exposure duration was studied and a signal saturation was observed after about 20 weeks. The comparison of TL signals due to solar light and to LINAC photons highlights a partial overlap of the two signals. Here, two different analysis procedures of glow curves (general order kinetics deconvolution and principal components analysis) are reported to point out components which depend differently on LINAC photon radiation dose. For both …
Les Marca (fin XVIIe - début XIXe siècles) : itinéraires et activités d'une dynastie de stucateurs piémontais en Franche-Comté et en Bourgogne
2013
The topic of this thesis is the Marca dynasty, a piedmontese family from the Valsesia area, specialized in the stucco work. In the early eighteenth century, some of its members migrated to the Franche-Comté in France, in search of work, the others remaining in Piedmont. Their realizations can be studied in religious places and private houses in Italy, in Franche-Comté and Burgundy. These works (altars, pulpits, statues and bas-reliefs in stucco) were created between the late seventeenth century and the early nineteenth century. This topic is entirely unpublished, especially as the information on this family are rare and scattered. Moreover, no research has been undertaken on it, neither in …
Modelling leaky photonic wires: a mode solver comparison
2006
We present results from a mode solver comparison held within the framework of the European COST P11 project. The structure modelled is a high-index contrast photonic wire in silicon-oninsulator subject to substrate leakage. The methods compared are both in-house developed and commercial, and range from effective index and perturbation methods, over finite-element and finite-difference codes, beam propagation methods, to film mode matching methods and plane wave expansion methods.
Mécanismes de résistance à l'apoptose induite par TRAIL dans les cellules cancéreuses : restauration de la sensibiltié à TRAIL par la chimiothérapie …
2010
The TNF-family member TRAIL (TNF-related apoptosis inducing ligand) is a cytokine involved in immune anti-tumour surveillance. TRAIL is one of the most promising agents currently under investigation, as it exhibits efficient anti-cancer cytotoxicity with limited side effects on healthy cells. The problem in current cancer therapy is that some cancer cells are already resistant, or can become resistant to TRAIL-induced cell death. The aim of my thesis was to study the mechanisms of resistance to TRAIL, and to find a way to bypass it. First, we were interested in the TRAIL-R4 antagonistic receptor, which is known to bind TRAIL without inducing a death signal. We have demonstrated for the firs…
Integrating Keyword Advertising and Dynamic Pricing for an Online Market Place
2014
Keyword Advertising is a main marketing instrument for e-commerce companies in order to generate traffic from search engines on their website. The costs for Keyword Advertising are determined in an auction that is conducted for every single search query, which is entered in by a user. In case of an online market place, each adlink provided by the search engine refers to an ordered list of products on the website of the online market place. Hereby, the price of the product is oftentimes one important criteria for the user when deciding for one or the other product from the list. However, existing models assume the price of products to be exogeneous. By taking into account the prices of linke…
Using Deep Learning to Extrapolate Protein Expression Measurements
2020
Mass spectrometry (MS)-based quantitative proteomics experiments typically assay a subset of up to 60% of the ≈20 000 human protein coding genes. Computational methods for imputing the missing values using RNA expression data usually allow only for imputations of proteins measured in at least some of the samples. In silico methods for comprehensively estimating abundances across all proteins are still missing. Here, a novel method is proposed using deep learning to extrapolate the observed protein expression values in label-free MS experiments to all proteins, leveraging gene functional annotations and RNA measurements as key predictive attributes. This method is tested on four datasets, in…
Study of Two-Photon Exchange via the Beam Transverse Single Spin Asymmetry in Electron-Proton Elastic Scattering at Forward Angles over a Wide Energy…
2020
We report on a new measurement of the beam transverse single spin asymmetry in electron-proton elastic scattering, $A^{ep}_{\perp}$, at five beam energies from 315.1 MeV to 1508.4 MeV and at a scattering angle of $30^{\circ} < \theta < 40^{\circ}$. The covered $Q^2$ values are 0.032, 0.057, 0.082, 0.218, 0.613 (GeV/c)$^2$. The measurement clearly indicates significant inelastic contributions to the two-photon-exchange (TPE) amplitude in the low-$Q^2$ kinematic region. No theoretical calculation is able to reproduce our result. Comparison with a calculation based on unitarity, which only takes into account elastic and $\mathrm{\pi N}$ inelastic intermediate states, suggests that there are ot…