Search results for "Keywords"
showing 10 items of 338 documents
Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multic…
2011
Granulocyte colony-stimulating factor (G-CSF) induces a transient mobilization of hematopoietic progenitor cells from bone marrow to peripheral blood. Our aim was to evaluate safety of repeated courses of G-CSF in patients with amyotrophic lateral sclerosis (ALS), assessing disease progression and changes in chemokine and cytokine levels in serum and cerebrospinal fluid (CSF). Twenty-four ALS patients entered an open-label, multicenter trial in which four courses of G-CSF and mannitol were administered at 3-month intervals. Levels of G-CSF were increased after treatment in the serum and CSF. Few and transitory adverse events were observed. No significant reduction of the mean monthly decrea…
Near Zero Energy House in Palestine: Identification of the Future Challenges
2015
Most of researches and experiences of the concept of near zero energy buildings (NZEBs) are highly concentrated on the developed countries more than the developing countries due to many reasons related to the different contexts conditions. This paper is a part of a PhD thesis, which is being supervised by the Department of Architecture at the University of Palermo. The paper aims at highlighting the challenges facing the house design in Palestine as a developing country in terms of NZEBs by making a study which is related to discussing different experiences in the field of energy saving strategies in Palestine and some surrounded countries, such as Jordan which shares certain climatic and a…
Poleward range expansion without a southern contraction in the ground beetle Agonum viridicupreum (Coleoptera, Carabidae)
2011
We investigated the extent of poleward shifts in the distribution range of Agonum viridicupreum due to climate change in the western Palaearctic. Species' records were obtained from extensive literature sources as well as from collections, and consistent amateur entomologists' recordings. Within the general geographic range of the species, we analyzed in detail two parts of both, the northern and southern distribution range boundaries: (1 and 2) north-western Germany (leading or high-latitude edge), (3) Israel and (4) southern Italy (rear or low-latitude edge). Temporal changes in the occurrence data of the species indicated a northward shift of the leading edge of a minimum of 100 km withi…
What Can Plans Do for Legal Theory?
2012
In his book, Legality (2011), Scott Shapiro puts forward what he claims to be "a new, and hopefully better" (better, namely, than the ones given so far) answer to "the overarching question of ‘What is law?’ - The central claim of this new account - the "Planning Thesis" - is that "legal activity is a form of social planning" -. "Legal institutions plan for the communities over which they claim authority, both by telling members what they may or may not do, and by identifying those who are entitled to affect what others may or may not do. Following this claim, legal rules are themselves generalized plans, or planlike norms, issued by those who are authorized to plan for others. And adjudicat…
Compromiso afectivo, liderazgo participativo e innovación del empleado: una investigación multinivel
2019
ABSTRACT Research investigating the relationship between organizational affective commitment and employee innovation has yielded scarce and inconsistent findings. This study examined the role of participative leadership in a team as a boundary condition of the effectiveness of organizational affective commitment predicting employee innovation. Data were collected from 343 employees in 34 teams from different Italian companies. The results from hierarchical linear modelling analysis indicated that the relationship between organizational affective commitment and employee innovation was stronger when team-level participative leadership was high. Our findings provide meaningful insights regardi…
Light Dark Matter Search with Ionization Signals in XENON1T
2019
We report constraints on light dark matter (DM) models using ionization signals in the XENON1T experiment. We mitigate backgrounds with strong event selections, rather than requiring a scintillation signal, leaving an effective exposure of (22±3) tonne day. Above ∼0.4 keVee, we observe <1 event/(tonne day keVee), which is more than 1000 times lower than in similar searches with other detectors. Despite observing a higher rate at lower energies, no DM or CEvNS detection may be claimed because we cannot model all of our backgrounds. We thus exclude new regions in the parameter spaces for DM-nucleus scattering for DM masses mχ within 3–6 GeV/c2, DM-electron scattering for mχ>30 MeV/c2, a…
The Attributive/Referential Distinction, Pragmatics, Modularity of Mind and Modularization
2011
In this paper I deal with the attributive/referential distinction. After reviewing the literature on the issue, I adopt Jaszczolt's view based on default semantics. I relate her view to Sperber and Wilson's Principle of Relevance. I argue in favour of the modularity hypothesis in connection with pragmatic interpretations. I also discuss the issue of modularization a la Karmiloff-Smith in connection with default inferences and, in particular, referential readings of NPs. I reply to some considerations by Cummings and use data from referential/attributive uses of NPs to show that the modularity hypothesis is defensible.
How an idea germinates into a projext or the intransitive resultative construction with Entity-Specific change-of-state verbs
2014
[EN] This study discusses how seven of Levin’s (1993) entity-specific change-of-state verbs (i.e. bloom, blossom, flower, germinate, sprout, swell, and blister) are subsumed into the intransitive resultative construction by highlighting and making use of the external and internal constraints proposed by the Lexical Constructional Model (LCM; Ruiz de Mendoza and Mairal 2007). External constraints refer to cognitive mechanisms such as high-level metaphor and/or metonymy whereas internal constraints are concerned with the encyclopedic and event structure makeup of verbs. The Internal Variable Conditioning constraint is at work when the information encapsulated by a predicate determines the cho…
Congenital emphysematous lung disease associated with a novel Filamin A mutation. Case report and literature review
2019
Abstract Background Progressive lung involvement in Filamin A (FLNA)-related cerebral periventricular nodular heterotopia (PVNH) has been reported in a limited number of cases. Case presentation We report a new pathogenic FLNA gene variant (c.7391_7403del; p.Val2464Alafs*5) in a male infant who developed progressive lung disease with emphysematous lesions and interstitial involvement. Following lobar resection, chronic respiratory failure ensued necessitating continuous mechanical ventilation and tracheostomy. Cerebral periventricular nodular heterotopia was also present. Conclusions We report a novel variant of the FLNA gene, associated with a severe lung disorder and PNVH. The lung disord…
Telomere Length in Circulating Leukocytes is Associated with Lung Function and Disease
2014
Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and s…