Search results for "L26"
showing 2 items of 12 documents
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models.
2018
Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma. In this paper, we describe a novel model faithfully recapitulating some key human GBM characteristics, including low mutational load, a factor reported as a prognostic indicator of ICB response. Consistent with this observation, SB28 is completely resistant to ICB, contrasting with treatment sensitivity of the more highly mutated GL261. Moreover, SB28 shows features of a poorly immunogenic tumor, with low MHC-I expression and modest CD8(+) T-cell infiltration, suggest…
Analysis of the determinants of entrepreneurial intention: the case of Burkina Faso
2018
International audience; In this study, we propose to analyze students' entrepreneurial intention, drawing on Lazear's (2004) self-selection model. This model captures the role of "human capital" in employment assignment and emphasizes the importance of the variety of skills in the individual's entrepreneurial orientation. For this purpose, we have a database collected in 2017 from over 1000 students at Ouaga I and Ouaga II universities in Burkina Faso. The results of estimates obtained using the quantile regression method show a positive and significant effect of the diversity of skills on the intention score, mainly at the median level. Even if the effect is not strong, this result support…