Search results for "L3"

A Revised Timescale for Human Evolution Based on Ancient Mitochondrial Genomes

2013

Summary Background Recent analyses of de novo DNA mutations in modern humans have suggested a nuclear substitution rate that is approximately half that of previous estimates based on fossil calibration. This result has led to suggestions that major events in human evolution occurred far earlier than previously thought. Results Here, we use mitochondrial genome sequences from ten securely dated ancient modern humans spanning 40,000 years as calibration points for the mitochondrial clock, thus yielding a direct estimate of the mitochondrial substitution rate. Our clock yields mitochondrial divergence times that are in agreement with earlier estimates based on calibration points derived from e…

Macrophage inflammatory protein-1.

2003

Macrophage inflammatory protein (MIP)-1alpha was identified 15 years ago as the first of now four members of the MIP-1 CC chemokine subfamily. These proteins termed CCL3 (MIP-1alpha), CCL4 (MIP-1beta), CCL9/10 (MIP-1delta), and CCL15 (MIP-1gamma) according to the revised nomenclature for chemokines are produced by many cells, particularly macrophages, dendritic cells, and lymphocytes. MIP-1 proteins, which act via G-protein-coupled cell surface receptors (CCR1, 3, 5), e.g. expressed by lymphocytes and monocytes/macrophages (MPhi), are best known for their chemotactic and proinflammatory effects but can also promote homoeostasis. The encouraging results of preclinical studies in murine model…

Presentación del monográfico ‘Economía social y sector no lucrativo’

2001

Global and sex-specific epigenome-wide association studies for the identification of the main methylated loci related to smoking in a mediterranean p…

2019

Abstract Background Tobacco use has been reported to be the main cause of 90% of male and 80% of female lung cancers, as well as a relevant risk factor for other cancers such as oropharynx, larynx, esophagus, stomach, liver, pancreas, kidney, bladder, and colorectum. Smoking directly affects DNA methylation and although several genes have been reported to be differentially methylated in smokers, gender differences and population-specific differences remain to be further investigated. Our aim was to undertake global and sex-specific genome-wide epigenomic studies (EWAS) in a Mediterranean population to identify the main smoking DNA-methylated genes. Methods We analyzed 88 participants in the…

A 1D coupled Schrödinger drift-diffusion model including collisions

2005

We consider a one-dimensional coupled stationary Schroedinger drift-diffusion model for quantum semiconductor device simulations. The device domain is decomposed into a part with large quantum effects (quantum zone) and a part where quantum effects are negligible (classical zone). We give boundary conditions at the classic-quantum interface which are current preserving. Collisions within the quantum zone are introduced via a Pauli master equation. To illustrate the validity we apply the model to three resonant tunneling diodes.

Lipoprotein profile and high-density lipoproteins: subfractions distribution in centenarians.

1998

In order to assess the role of HDL on longevity, we studied HDL subfraction distribution in centenarian women compared with a group of weight- and gender-matched healthy normolipidemic controls. We did not find any significant difference in the mean plasma lipid, apolipoprotein, and Lp(a) levels. On the contrary, in spite of similar HDL-cholesterol concentrations (1.32 ± 0.41 mmol/l in centenarians vs. 1.32 ± 0.25 mmol/l in controls, p = not significant), HDL<sub>2b</sub> and HDL<sub>3a</sub> levels were, respectively, significantly increased and significantly reduced in centenarians in comparison with controls (HDL<sub>2b</sub> 32.4 ± 9.2% in centenarian…

Un enfoque de marketing de relaciones a la educación como un servicio: aplicación a la Universidad de Valencia

2014

Esta investigación se plantea como una aproximación exploratoria a la vez que innovadora, en la medida en que su objetivo básico es el de aplicar el paradigma del marketing de relaciones al análisis de la gestión educativa. Más concretamente, lo que se persigue es construir un modelo integrado de relaciones entre el egresado y la universidad. Se realizaron 500 encuestas a egresados de una universidad española y se utilizaron modelos de ecuaciones estructurales para contrastar las relaciones planteadas. La aportación fundamental del trabajo radica en la conceptuación y medición de variables relativas al comportamiento y percepción de los egresados. Los resultados más relevantes confirman tre…

On GIT quotients of Hilbert and Chow schemes of curves

2011

The aim of this note is to announce some results on the GIT problem for the Hilbert and Chow scheme of curves of degree d and genus g in P^{d-g}, whose full details will appear in a subsequent paper. In particular, we extend the previous results of L. Caporaso up to d>4(2g-2) and we observe that this is sharp. In the range 2(2g-2)<d<7/2(2g-2), we get a complete new description of the GIT quotient. As a corollary, we get a new compactification of the universal Jacobian over the moduli space of pseudo-stable curves.

Reconnoitering the Role of Long-Noncoding RNAs in Hypertrophic Cardiomyopathy: A Descriptive Review

2021

Hypertrophic cardiomyopathy (HCM) is the most common form of hereditary cardiomyopathy. It is characterized by an unexplained non-dilated hypertrophy of the left ventricle with a conserved or elevated ejection fraction. It is a genetically heterogeneous disease largely caused by variants of genes encoding for cardiac sarcomere proteins, including MYH7, MYBPC3, ACTC1, TPM1, MYL2, MYL3, TNNI3, and TNNT23. Preclinical evidence indicates that the enhanced calcium sensitivity of the myofilaments plays a key role in the pathophysiology of HCM. Notably, this is not always a direct consequence of sarcomeric variations but may also result from secondary mutation-driven alterations. Long non-coding R…

Lattice operations on Rickart *-rings

2014

Various authors have investigated properties of the star order (introduced by M.P. Drazin in 1978) on algebras of matrices and of bounded linear operators on a Hilbert space. Rickart involution rings (*-rings) are a certain algebraic analogue of von Neumann algebras, which cover these particular algebras. In 1983, M.F. Janowitz proved, in particular, that, in a star-ordered Rickart *-ring, every pair of elements bounded from above has a meet and also a join. However, the latter conclusion seems to be based on some wrong assumption. We show that the conclusion is nevertheless correct, and provide equational descriptions of joins and meets for this case. We also present various general proper…