Search results for "LAB"
showing 10 items of 7932 documents
Assessing the impact of copy number variants on miRNA genes in autism by Monte Carlo simulation.
2014
Autism Spectrum Disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies have investigated the role of de novo Copy Number Variants (CNVs) and microRNAs as important but distinct etiological factors in ASD. We developed a novel computational procedure to assess the potential pathogenic role of microRNA genes overlapping de novo CNVs in ASD patients. Here we show that for chromosomes # 1, 2 and 22 the actual number of miRNA loci affected by de novo CNVs in patients was found significantly higher than that estimated by Monte Carlo simulation of random CNV events. Out of 24 miRNA genes over-represented in CNVs from these three chromosomes only …
Therapeutic Angiogenesis in Surgery and Oncology
1994
The aim of this presentation is to demonstrate the pathological importance of microenvironmental tissue hypoxia and to elucidate a general treatment concept for this situation which we have termed therapeutic angiogenesis 1. Hypoxia not only represents an insufficient oxygen supply for the cells of a given tissue area but is also regarded as an indicator for their metabolic deprivation and the concomitant accumulation of waste products. Therapeutic angiogenesis applied either with clinically established methods or using novel ways, which are the objectives of laboratory research and clinical trials at present, or in so far hypothetical forms, should lead to an expansion of the functional mi…
A Novel Chitin-binding Protein from the Vestimentiferan Riftia pachyptila Interacts Specifically with β-Chitin
2001
Abstract A cDNA from Riftia pachyptila was cloned. It encodes a novel 21.3-kDa protein from the worm protective tube, named RCBP (for Riftia chitin-binding protein). On the basis of partial tube-peptide sequences previously obtained, experiments using reverse transcriptase-mediated polymerase chain reaction and rapid amplification of cDNA ends led to the complete cDNA sequence. Analysis of its deduced amino acid sequence shows the presence of two chitin-binding domains. These domains are closely related to type 2 chitin-binding domains that are restricted to the animal kingdom. We showed by affinity assay and immunogold labeling that RCBP is the first protein so far known that binds specifi…
Comparative analysis of architectures for monitoring cloud computing infrastructures
2015
The lack of control over the cloud resources is one of the main disadvantages associated to cloud computing. The design of efficient architectures for monitoring such resources can help to overcome this problem. This contribution describes a complete set of architectures for monitoring cloud computing infrastructures, and provides a taxonomy of them. The architectures are described in detail, compared among them, and analysed in terms of performance, scalability, usage of resources, and security capabilities. The architectures have been implemented in real world settings and empirically validated against a real cloud computing infrastructure based on OpenStack. More than 1000 virtual machin…
Autonomic Brokerage Service for an End-to-End Cloud Networking Service Level Agreement
2014
8 pages; International audience; Today, cloud networking which is the ability to connect the user with his cloud services and to interconnect these services within an inter-cloud approach, is one of the recent research areas in the cloud computing research communities. The main drawback of cloud networking consists in the lack of Quality of Service (QoS) assurance and management in conformance with a corresponding Service Level Agreement (SLA). In this paper, we propose a framework for self-establishing an end-to-end service level agreement between a Cloud Service User (CSU) and multiple Cloud Service Providers (CSPs) in a cloud networking environment using brokerage service. We focus on Qo…
Role of Data Communications in Hybrid Cloud Costs
2011
Rapid adoption of cloud services in recent years has been driven by multiple factors, such as faster time-to-market and improved scalability enabled by public cloud infrastructure. Hybrid clouds, combining the in-house capacities with on-demand capacity of public clouds, achieve both the increased utilization rate of the in-house infrastructure and the limited use of more expensive public cloud, thereby lowering the total costs for the cloud user. In this paper, an analytical model of hybrid cloud costs is introduced, wherein the costs of computing and data communication are taken into account. Using this model, the costefficient division of the computing capacity between the private and th…
Crowdboard: An Augmented Whiteboard to Support Large-Scale Co-Design
2013
Co-design efforts attempt to account for many diverse viewpoints. However, design teams lack support for meaningful real-time interaction with a large community of potential stakeholders. We present Crowdboard, a novel whiteboard system that enables many potential stakeholders to provide real-time input during early-stage design activities, such as concept mapping. Local design teams develop ideas on a standard whiteboard, which is augmented with annotations and comments from online participants. The system makes it possible for design teams to solicit real-time opinions and ideas from a community of people intrinsically motivated to shape the product/service.
La investigación en el aula a través de las redes sociales: co-diseño de un blog como herramienta de innovación y mejora de la docencia.
2020
[ES] El nuevo Espacio Europeo de Educación ha supuesto la incorporación de nuevas metodologías y dinámicas digitales en entornos formales como el ámbito universitario, motivando al alumnado a involucrarse en sus procesos de aprendizaje colaborativo dentro del aula. A través de la asignatura Investigación en Sistemas de Bienestar Social del grado de Trabajo Social de la Universitat de València se ha llevado a cabo un proyecto de innovación docente, financiado por dicha universidad, con el objetivo de mejorar la docencia a través del uso de las redes sociales para la construcción e intercambio de conocimiento superior en materia de investigación. Concretamente, se ha co-diseñado junto al alum…
Querytogether : Enabling entity-centric exploration in multi-device collaborative search
2018
Collaborative and co-located information access is becoming increasingly common. However, fairly little attention has been devoted to the design of ubiquitous computing approaches for spontaneous exploration of large information spaces enabling co-located collaboration. We investigate whether an entity-based user interface provides a solution to support co-located search on heterogeneous devices. We present the design and implementation of QueryTogether, a multi-device collaborative search tool through which entities such as people, documents, and keywords can be used to compose queries that can be shared to a public screen or specific users with easy touch enabled interaction. We conducted…
Problemática laboral de los socios trabajadores de las empresas de Economía Social: ¿socios o trabajadores?
1999
Co-operatives and labour societies are the most important organisations within the framework of Social Economy. The establishment of these societies, which create employment in the private sector with a democratic philosophy based on mutual help, has been recently boosted thanks to the support of public power. Their growing importance can be explained by three factors: the Employment Policy, the Social Policy and the productive decentralisation. As far as labour is concerned, these societies offer the following advantages: intensive use of labour, high rate of stability in employment, high levels of productivity, training and surplus re-inversion, lower rate of inflation, fewer conflicts th…