Search results for "LIANT"

showing 10 items of 74 documents

Cytotoxic Bufadienolides from the Leaves of Melianthus major

2020

Melianthus major is a medicinal plant endemic to South Africa. Its leaf extract led to the isolation of five new bufadienolides, 2β-acetoxy-3,5-di-O-acetylhellebrigenin (1), 2β-acetoxy-3-O-acetylhellebrigenin (2), 2β-acetoxy-14-deoxy-15β,16β-epoxymelianthugenin (4), 2β-acetoxy-14-deoxy-15β,16β-epoxymelianthusigenin (5), and 2β-hydroxymelianthusigenin (6), and four known analogues. The structures of the compounds were elucidated using NMR and HRESIMS data analyses. The relative configurations were defined by single-crystal X-ray crystallography and NOESY correlations. The isolated compounds exhibited strong cytotoxicity against MCF-7 breast cancer cells and sensitive CCRF-CEM and multidrug-r…

Pharmacologybiology010405 organic chemistryChemistryCcrf cemOrganic ChemistryPharmaceutical Sciencemedicine.diseasebiology.organism_classification01 natural sciencesMolecular biologyMelianthus major0104 chemical sciencesAnalytical Chemistry010404 medicinal & biomolecular chemistryLeukemiaComplementary and alternative medicineDrug DiscoverymedicineIc50 valuesMolecular MedicineCytotoxic T cellBreast cancer cellsCytotoxicityTwo-dimensional nuclear magnetic resonance spectroscopyJournal of Natural Products
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Up-to-date report on the distribution ofHelianthemum lippii(Cistaceae) in Italy

2015

An up-to-date report on the distribution of Helianthemum lippii in Italy is provided also on the basis of the findings by Lojacono-Pojero in 1889 who reported the existence of a relic population in Sicily (southern Italy), which is now thought to be extinct because of human disturbance. Field excursions permitted to confirm the locus classicus reported by Lojacono-Pojero as the other Sicilian localities that have been reported more recently. Based on a careful analysis of the literature the presence of H. lippii is currently excluded in Calabria and Apulia. The main causes that threaten the habitat of H. lippii in Sicily are pointed out according to IUCN Threats Classification Scheme.

PopulationClassification schemePlant ScienceCistaceaelocus classicudistributionHelianthemum lippiiIUCN Red ListeducationEcology Evolution Behavior and Systematicseducation.field_of_studyEcologybiologyEcologySettore BIO/02 - Botanica Sistematicabiology.organism_classificationlanguage.human_languageGeographyItalyHabitatSettore BIO/03 - Botanica Ambientale E ApplicatalanguageIUCN Threats Classification SchemeSicilianCartographyHelianthemum lippiiWebbia
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Connecting the data landscape of long-term ecological studies: the SPI-Birds data hub

2021

The integration and synthesis of the data in different areas of science is drastically slowed and hindered by a lack of standards and networking programmes. Long-term studies of individually marked animals are not an exception. These studies are especially important as instrumental for understanding evolutionary and eco-logical processes in the wild. Furthermore, their number and global distribution provides a unique opportunity to assess the generality of patterns and to address broad-scale global issues (e.g. climate change).

SELECTION0106 biological sciencesZOOLOGIADatabases Factual05 Environmental Sciences:Zoology and botany: 480 [VDP]Research network01 natural scienceslong‐term studiesBehavioral EcologyData standardsmeta‐data standardsData hubComputingMilieux_MISCELLANEOUSResearch Articlesmeta‐PERSONALITYCLIMATE-CHANGEEcologyEnvironmental resource managementALTERmeta&#8208birds data standards database FAIR data long-term studies meta-data standards research networkPE&RCGedragsecologieChemistryGeographyinternational[SDE]Environmental Sciences1181 Ecology evolutionary biologyPOPULATIONSPlan_S-Compliant_OALife Sciences & Biomedicinelong‐Research ArticleCLUTCH-SIZELong-term studiesEnvironmental Sciences & EcologyAnimal Breeding and GenomicsZoologi15.- Proteger restaurar y promover la utilización sostenible de los ecosistemas terrestres gestionar de manera sostenible los bosques combatir la desertificación y detener y revertir la degradación de la tierra y frenar la pérdida de diversidad biológica010603 evolutionary biologyBirdsDatabase07 Agricultural and Veterinary Sciencesddc:570VDP::Mathematics and natural scienses: 400::Zoology and botany: 480AnimalsFokkerij en Genomica:Zoologiske og botaniske fag: 480 [VDP]BiologyEcology Evolution Behavior and SystematicsMeta-data standardsMetadataFAIR dataScience & Technologylong&#8208business.industry010604 marine biology & hydrobiology06 Biological Sciences15. Life on landdatabase ; meta-data standards ; long-term studies ; birds ; data standards ; FAIR data ; research networkEVOLUTIONTerm (time)13. Climate actionResearch councilVDP::Matematikk og naturvitenskap: 400::Zoologiske og botaniske fag: 480Animal Science and Zoologyterm studiesGREAT TITSbusinessZoologybirds ; data standards ; database ; FAIR data ; long-term studies ; meta-data standards ; research networkRESPONSES
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Comparative study onSalmonellaisolation from sewage-contaminated natural waters

1984

Alcaide, E., Martinez, J.P. & Garay, E. 1984. Comparative study on Salmonella isolation from sewage contaminated natural waters. Journal of Applied Bacteriology56, 365–371. A comparative study of five factors influencing the isolation of salmonellas from sewage-contaminated natural waters was carried out. The effect of pre-enrichment in buffered peptone water was compared with single-step enrichment in NR10 broth incubated at 43dC. A modification of NR10 has been compared with the original composition. Bismuth sulphite agar (BSA), Hektoen enteric agar (HE) and brilliant green agar (BGA) have been used as plating media. Other factors considered have been temperature of the water and sampling…

Salmonellafood.ingredientSewageFresh WaterBiologymedicine.disease_causeApplied Microbiology and BiotechnologyMicrobiologyMicrobiologychemistry.chemical_compoundfoodSalmonellamedicineAgarFood scienceWater pollutionSewagebusiness.industryHektoen enteric agarContaminationIsolation (microbiology)Culture MediaBrilliant greenchemistryWater MicrobiologybusinessJournal of Applied Bacteriology
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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Design of a wiper as compliant mechanisms with a monolithic layout

2020

The increasingly important need to design simpler structures, reducing the number of constituent components, has motivated the approach outlined in this paper which proposes an effective re-engineering example of a product belonging to the automotive industry, combining the advantages offered by the compliant mechanisms with production opportunities linked to the use of additive manufacturing. Take advantage of compliant mechanisms makes it possible to significantly improve the component's production phase, leading to undoubted benefits on the supply chain and on product’s time to market, benefits made possible by exploiting the outstanding characteristic of additive manufacturing to produc…

Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di MacchineComputer scienceCompliant mechanismCompliant mechanisms Monocomponent Wiper Additive ManufacturingMechanical engineeringGeneral Medicine
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L’investissement conforme à la Charia est-il socialement responsable ?

2019

Cette étude propose une réflexion inédite sur la pertinence d’inclure l’ICC dans la sphère de l’ISR. Nous établissons une comparaison à la fois qualitative et quantitative entre ces deux types d’investissement pour comprendre dans quelle mesure l’ICC se distingue de l’ISR. Les résultats révèlent une surperformance financière de l’ICC en période de crise en dépit d’une sous-performance sociétale. Nous concluons que, bien que l’ICC obéisse à une certaine conception de l’ISR, la non-inclusion des considérations ESG dans ses règles de management actuelles devrait conduire les communautés académique et professionnelle à le traiter en tant que type d’investissement à part entière.

Social Sciences and Humanities050208 financeShariah compliant investment05 social sciencesinversión socialmente responsableGeneral Medicinesocially responsible investmentperformance financièreperformance sociétaleinversión conforme a shariahfinancial performanceinvestissement conforme à la Chariainvestissement socialement responsablesocietal performancedesempeño financiero0502 economics and businessdesempeño socialSciences Humaines et Sociales050203 business & managementManagement international
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CCDC 1981430: Experimental Crystal Structure Determination

2020

Related Article: Kibrom Gebreheiwot Bedane, Lukas Brieger, Carsten Strohmann, Ean-Jeong Seo, Thomas Efferth, Michael Spiteller|2020|Bioorg.Chem.|102|104102|doi:10.1016/j.bioorg.2020.104102

Space GroupCrystallographyCrystal System16beta-formyloxymelianthugenin monohydrateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1961567: Experimental Crystal Structure Determination

2020

Related Article: Kibrom Gebreheiwot Bedane, Lukas Brieger, Carsten Strohmann, Ean-Jeong Seo, Thomas Efferth, Michael Spiteller|2020|J.Nat.Prod.|83|2122|doi:10.1021/acs.jnatprod.0c00060

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters14-deoxy-15beta16beta-epoxymelianthugeninExperimental 3D Coordinates
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Cytotoxic bufadienolides from the leaves of a medicinal plant Melianthus comosus collected in South Africa.

2020

Abstract From the leaves of South African medicinal plant Melianthus comosus, four previously undescribed bufadienolides, 16β-formyloxymelianthugenin (1), 2β-acetoxymelianthusigenin (2), 2β-hydroxy-3β,5β-di-O-acetylhellebrigenin (3), and 2β-acetoxy-5β-O-acetylhellebrigenin (4) were isolated together with two known bufadienolides. The structural elucidation of the compounds was based on 1D and 2D NMR spectroscopy, high-resolution mass spectrometry, and other spectroscopic methods. The relative configurations were determined by single-crystal X-ray crystallography analysis and NOESY correlations. The isolated compounds displayed strong cytotoxicity against MCF-7 breast cancer cells, sensitive…

StereochemistryMolecular ConformationMass spectrometry01 natural sciencesBiochemistrySouth AfricaStructure-Activity RelationshipCell Line TumorDrug DiscoveryIc50 valuesCytotoxic T cellHumansCytotoxicityMolecular BiologyCell ProliferationPlants MedicinalbiologyDose-Response Relationship Drug010405 organic chemistryChemistryOrganic ChemistryStereoisomerismMelianthus comosusbiology.organism_classificationAntineoplastic Agents Phytogenic0104 chemical sciencesBufanolidesPlant Leaves010404 medicinal & biomolecular chemistryBreast cancer cellsDrug Screening Assays AntitumorTwo-dimensional nuclear magnetic resonance spectroscopyBioorganic chemistry
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