Search results for "LIBER"

Mucoadhesive solid lipid microparticles for controlled release of a corticosteroid in the chronic obstructive pulmonary disease treatment.

2017

Therapeutic efficacy of inhaled drugs is limited by rapid clearance from the site of action due to absorption into systemic circulation or metabolic degradation by alveolar macrophages. Drug delivery systems offer new solutions to clinical problems especially in the treatment of pulmonary diseases. In particular, Solid Lipid Microparticles (SLM) in the range of 3-5 µm are suggested as systems for delivery of therapeutics to the lung as, because of their size, they are able to deposit into secondary bronchi, avoiding systemic absorption typical of alveolar regions. Here, we describe two novel different SLMs prepared with chitosan and alginate for sustained release of fluticasone propionate (…

Evaluation of Second-line Anti-VEGF after First-line Anti-EGFR Based Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Multicenter “SLAVE” S…

2020

: Background: The optimal anti-angiogenic strategy as second-line treatment in RAS wild-type metastatic colorectal cancer (mCRC) treated with anti-EGFR (Epidermal Growth Factor Receptor) based first-line treatment is still debated. Methods: This multicenter, real-world, retrospective study is aimed at evaluating the effectiveness of second-line Bevacizumab- and Aflibercept-based treatments after an anti-EGFR based first-line regimen. Clinical outcomes measured were: objective response rate (ORR), progression free survival (PFS), overall survival (OS) and adverse events (AEs) profiles. Results: From February 2011 to October 2019, 277 consecutive mCRC patients received Bevacizumab-based (228,…

Aflibercept in combination with irinotecan, fluorouracil and leucovorin (FOLFIRI) as first-line chemotherapy in metastatic colorectal cancer (mCRC) p…

2018

Two-Week Aflibercept or Erlotinib Administration Does Not Induce Changes in Intestinal Morphology in Male Sprague–Dawley Rats But Aflibercept Affects…

2019

Gastrointestinal toxicity is a frequently observed adverse event during cancer treatment with traditional chemotherapeutics. Currently, traditional chemotherapeutics are often combined with targeted biologic agents. These biologics, however, possess a distinct toxicity profile, and they may also exacerbate the adverse effects of traditional chemotherapeutics. In this study, we aimed to characterize the gastrointestinal and metabolic changes after a 2-week treatment period with aflibercept, an antiangiogenic VEGFR decoy, and with erlotinib, a tyrosine-kinase inhibitor. Male rats were treated either with aflibercept or erlotinib for 2 weeks. During the 2-week treatment period, the animals in …

TGF-β Serum Levels in Diabetic Retinopathy Patients and the Role of Anti-VEGF Therapy.

2020

Transforming growth factor &beta

Effect of Calcium Ions on the Disintegration of Enteric-Coated Solid Dosage Forms.

2015

To investigate the effect of calcium ions on the disintegration of enteric-coated dosage forms, disintegration testing was performed on enteric-coated aspirin tablets in the presence and absence of calcium in the test media. The results show that the presence of calcium ions retards the disintegration of enteric-coated dosage forms. This finding, which has not been reported in scientific literature, sheds light on the importance of conducting well-designed detailed investigations into the potential of calcium from dietary sources, calcium supplements, antacids, and/or phosphate binders affecting the absorption of drugs formulated into enteric-coated dosage forms. Moreover, it shows the nece…

Spanish Validation of the Polymorphous Prejudice Scale in a Sample of University Students

2016

ABSTRACTThe shortened version of the Polymorphous Prejudice Scale (PPS) analyzes new manifestations of prejudice toward gay men and lesbian women. Specifically, this instrument consists of 16 items distributed in four subscales: values gay progress, positive beliefs about gay men, positive beliefs about lesbian women, and resistance to heteronormative expectations. The aim of the current study is to add new evidence about the reliability and validity of the scale. The scale is administrated to 348 heterosexual university students from Spain with a mean age of 22.62 years (SD = 7.63). Reliability and factorial validity estimates are presented. A four-factor structure is supported using confi…

Trade, financial openness and dual banking economies: Evidence from GCC Region

2021

Abstract The recent wave of liberalization in Gulf Cooperation Council (GCC) countries has opened up a debate on the role of Islamic finance in the financial development of an economy. Using a comprehensive dataset of 43 Islamic and 49 conventional banks for the period 2007–2015, in this paper, we investigate the impact of trade and financial openness on financial development in the GCC region. We find that trade and financial openness have a positive effect on the profitability of both banking systems, while the interaction term of openness is negative for the profitability of Islamic banks. Moreover, trade and financial openness affect Islamic banks differently than conventional banks. No…

Prosodic modulation as a mark to express pragmatic values: The case of mitigation in Spanish

2021

Abstract One of the functions of prosody in discourse is to convey pragmatic values that add up to the core semantic meaning of spoken units or segments. Regarding mitigation, Caffi (1999: 890) specifically discusses “the very important prosodic and kinesic means of mitigation, such as changes in pitch prominence, rhythm, speech rate, as well as eye-contact, gaze, gaze aversion, smile, particular postures, etc.” In this paper, I focus on some prosodic factors such as pitch, intensity, duration and speech rate that can be used in European Spanish, in combination with pragmatic meanings. The first aim is to establish a theoretical deliberation on prosody as a clear marker to convey pragmatic …

Incivility in online news and Twitter: effects on attitudes toward scientific topics when reading in a second language

2021

Due to the participatory nature of Web 2.0, polite communication on social media and news sites can stand side by side with uncivil comments. Research on online incivility has been conducted with users reading in their mother tongues (L1), while the potential effects of incivility in a second language (L2) have been largely under- explored. This paper analyzes the effects of uncivil comments written in an L2 on attitudes around emerging technologies. Accordingly, study 1 replicates and extends a previous experiment on the effects of incivility to online news on risk perceptions of nanotechnology (Anderson et al., 2014), by adding an ‘L2 condition’ (uncivil comments written in an L2). Then, …