Search results for "LIBER"
showing 10 items of 1718 documents
Adapting RRI public engagement indicators to the Spanish scientific and innovation context: a participatory methodology based on AHP and content anal…
2022
The paradigm proposed by Responsible Research and Innovation in the European Commission policy discourse identifies Public Engagement as a key area for exchange and dialogue among multiple actors following an inclusive and participatory process. Two definite set of indicators have already arisen at European level to monitor Public Engagement activities in the Science and Innovation realm. Our study aims to propose a deliberative participatory process, which involves selected stakeholders, for the adaptation of the European indicators to the specific Spanish scientific and innovation context. The methodological procedure is of exploratory nature and will be based in a combination of, on the …
La compleja configuración de un derecho-libertad poliédrico, el derecho a la información. Referencias históricas
2017
This work focuses on the origins of the right to communicate and aims to highlight some of the peculiarities that help explain that, even if there is a legal precedent that dates back centuries, its Constitutional adoption in Europe only happened well into the 20th century. We must insist that this right must not be confused with freedom of expression, as many references that deal with this topic from a historical perspective aim to highlight the differences between both rights/freedoms. Even if the stronger tradition and development of freedom of expression as a right tends to absorb the right to communicate as one of its parts, this text explains the different political function of both r…
Essai sur la liberté : considérée comme principe et fin de l'activité humaine
1863
La revisión de oficio de los actos nulos por infracción de los derechos fundamentales: doctrina del consejo jurídico consultivo de la Comunitat Valen…
2012
El artículo 102 de la Ley 30/1992 establece, en su párrafo primero, que «Las Administraciones públicas, en cualquier momento, por iniciativa propia o a solicitud del interesado, y previa dictamen favorable del Consejo de Estado u órgano consultivo equivalente de la Comunidad Autónoma, si lo hubiere, declararán de oficio la nulidad de los actos administrativos que hayan puesto fin a la vía administrativa o que no hayan sido recurridos en plazo, en los supuestos previstos en el artículo 62.1».
Taxe d'inhabitation
2000
International audience
Contribution à l'étude des évolutions contemporaines du droit constitutionnel français
2016
Classiquement consacré à l’étude des institutions politiques, le droit constitutionnel s’est enrichi de l’étude du système normatif, notamment dans ses liens avec les systèmes juridiques régionaux et internationaux, et de la protection des droits et libertés fondamentaux. Les travaux de recherche présentés dans ce mémoire ne portent pas sur l’étude des institutions politiques mais intéressent en revanche les deux autres domaines du droit constitutionnel.S’agissant de l’étude du système normatif, il apparaît qu’il s’ajuste progressivement pour mieux intégrer les contraintes liées au développement du droit international en général et du droit de l’Union européenne et de la Convention européen…
Plaidoyer pour la liberté d'expression, droit fondamental de l'entreprise
2011
International audience
Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release
2021
We thank Dr H. Häkkänen for technical assistance and S. Julin for the 24HB DNA origami design. We acknowledge the provision of facilities and technical support by Aalto University Bioeconomy Facilities and OtaNano – Nanomicroscopy Center (Aalto-NMC). The research was carried out under the Academy of Finland Centres of Excellence Programme (2014–2019). Academy of Finland [308578 to M.A.K.]; Deutsche Forschungsgemeinschaft [Emmy Noether Programme to A.H.-J., SFB1032 (Project A06) to T.L.]; Emil Aaltonen Foundation [to H.I. and V.L.]; Jane and Aatos Erkko Foundation [to J.A.I. and V.L.]; Sigrid Jusélius Foundation [to V.L.]; Vilho, Yrjö and Kalle Väisälä Foundation of the Finnish Academy of Sc…
Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications.
2016
To optimally exploit the potential of (tumor-) targeted nanomedicines, platform technologies are needed in which physicochemical and pharmaceutical properties can be tailored according to specific medical needs and applications. We here systematically customized the properties of core-crosslinked polymeric micelles (CCPM). The micelles were based on mPEG-b-pHPMAmLacn (i.e. methoxy poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl) methacrylamide-lactate]), similar to the block copolymer composition employed in CriPec® docetaxel, which is currently in phase I clinical trials. The CCPM platform was tailored with regard to size (30 to 100 nm), nanocarrier degradation (1 month to 1 year) and drug…
Core-Shell Arginine-Containing Chitosan Microparticles for Enhanced Transcorneal Permeation of Drugs
2019
Chitosan oligosaccharide (C) was functionalized with L-arginine (A) and short hydrocarbon chains (C-8) to design an amphiphilic copolymer, henceforth CAC(8), leading to microparticles (MPs) consisting of an arginine-decorated hydrophilic shell and inner hydrophobic domains allowing the encapsulation of high amount hydrophobic drugs such as sorafenib tosylate (>10% w/w). L-arginine side chains were selected in order to impart the final MPs enhanced transcorneal penetration properties, thus overcoming the typical biological barriers which hamper the absorption of drugs upon topical ocular administration. The mucoadhesive properties and drug release profile of the CAC(8) MPs (CAC(8)-MPs) were …