Search results for "LIBERATION"
showing 10 items of 198 documents
NATURE AND DELIBERATION IN BESSARION'S DE NATURA ET ARTE
2015
AbstractThe present contribution will concentrate on the central issue discussed by Bessarion in one of his major works, the De natura et arte (written in 1458 and published in 1469 as the sixth book of Bessarion’s In calumniatorem Platonis), i. e. the concept of deliberation and the relationship between nature, purposiveness and deliberation. In De natura et arte Bessarion responds to an attack by George of Trebizond, who had demonstrated, against Bessarion, not only that nature does not deliberate, but also that deliberation cannot be attributed to God who guides nature either, since deliberation implies doubt and ignorance. In this contribution I will examine the strategies Bessarion use…
Democrazia deliberativa e Convenzione europea dei diritti umani
2010
Deliberative democracy and the European Convention on Human Rights Theories of deliberative democracy have rapidly become very popular amongst political scientists. The central argument of these theories is that democratic legitimacy of lawmaking does not lie (or does not only lie) in the elected character of Parliaments but in public delib- eration processes. Decisions have to be justified by reasons and reasons have to be publicly debated. Legitimacy also depends on the opportunity for citizens to participate effectively in public debates. In this paper I argue that the European Court of Human Rights can be a key player in promoting a democracy based on public deliberation and that in the…
Democracia y deliberación pública desde la perspectiva rawlsiana
2004
En el presente trabajo me centro, principalmente, en una de las cuestiones que ocupan, a mi modo de ver, el primer plano de la reflexión teórica actual: el problema de la democracia como forma política del uso público de la razón por parte de todos, estudiándolo desde el paradigma que nos ofrece John Rawls en sus últimas obras. Sobre todo en el papel y límite que Rawls asigna a la «Razón pública» y la «Deliberación pública», cuyo análisis me parece enormemente sugerente e iluminador para la Teoría democrática contemporánea. He analizado, en primer lugar, la relación entre democracia y concepción política de justicia, y en segundo, la razón pública y los límites de la deliberación pública. C…
Nanoparticle formulations as recrystallization inhibitors in transdermal patches
2020
Abstract Drug crystallization in transdermal patches is still a major challenge, confronting the formulation development of topical drug delivery systems. Encapsulation of drugs into nanoparticles is proposed here as a promising tool for regulating drug crystallization in transdermal patches. The degree of recrystallization and transdermal permeation of ibuprofen and hydrocortisone loaded in polymeric and lipid nanoparticles from matrix-type transdermal patches were investigated. Ethyl cellulose (EC4), poly (lactide-co-glycolic acid) (PLGA) and polycaprolactone (PCL) were employed for polymeric nanoparticle preparations; while medium chain triglyceride (MCT) and witepsol were used for the p…
Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy
2014
This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnet…
recensione di Daniele Sanna (a cura di), La Sardegna e la guerra di Liberazione. Studi di storia militare
2019
Il volume ricostruisce il ruolo dei "combattenti, in gran parte militari" sardi e delle "istituzioni militari" nella guerra di Liberazione. Il volume vuole inserirsi all'interno del filone di studi sulla partecipazione dei meridionali alla Liberazione.
Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells
2015
In recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming common issues such as poor water solubility and poor stability of some drugs. In particular, redox-responsive delivery systems have attracted the attention of scientists because of the intracellular reductive environment related to a high concentration of glutathione (GSH). In this context, we describe herein the development of a GSH-responsive delivery system based on poly(ethylene glycol)- (PEG-)…
Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation.
2018
Regulatory guidelines recommend that, when a level A IVIVC is established, dissolution specification should be established using averaged data and the maximum difference between AUC and Cmax between the reference and test formulations cannot be greater than 20%. However, averaging data assumes a loss of information and may reflect a bias in the results. The objective of the current work is to present a new approach to establish dissolution specifications using a new methodology (individual approach) instead of average data (classical approach). Different scenarios were established based on the relationship between in vitro-in vivo dissolution rate coefficient using a level A IVIVC of a cont…
Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study.
2017
Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to gauge the reproducibility of results obtained with these methods. The aim of this study was to determine the interlaboratory reproducibility of biorelevant dissolution testing, using the paddle apparatus (USP 2). Thirteen industrial and three academic laboratories participated in this study. All laboratories were provided with standard protocols for running the tests: dissolution in FaSSGF to simulate release in the stomach, dissolution in a singl…
Intangible Cultural Heritage exposed to Public Deliberation: A Participatory Experience in a Regional Nature Park
2017
International audience