Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells

6533b86cfe1ef96bd12c80d9

RESEARCH PRODUCT

Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells

José Ramón Murguía Cristina De La Torre Mónica Gorbe Elena Aznar Cristina Giménez M. Dolores Marcos Pedro Amorós Ramón Martínez-máñez Félix Sancenón

subject

INGENIERIA DE LA CONSTRUCCION Cell Survival Intracellular Space Nanoparticle Nanotechnology Antineoplastic Agents CONTROLLED-RELEASE TRIGGERED RELEASE Polyethylene Glycols chemistry.chemical_compound INORGANIC NANOPARTICLES QUIMICA ORGANICA SYSTEMS PEG ratio QUIMICA ANALITICA Electrochemistry medicine POLYMER HYBRID NANOPARTICLES GLUTATHIONE BIOQUIMICA Y BIOLOGIA MOLECULAR Humans General Materials Science Doxorubicin Spectroscopy Drug Carriers ENHANCED PERMEABILITY QUIMICA INORGANICA Surfaces and Interfaces Glutathione IN-VITRO Mesoporous silica Condensed Matter Physics Silicon Dioxide Controlled release GUEST MOLECULES Bioavailability Drug Liberation chemistry Doxorubicin Delayed-Action Preparations Drug Design Nanoparticles Phenazines SUPPORTS Ethylene glycol Oxidation-Reduction Porosity medicine.drug HeLa Cells

description

In recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming common issues such as poor water solubility and poor stability of some drugs. In particular, redox-responsive delivery systems have attracted the attention of scientists because of the intracellular reductive environment related to a high concentration of glutathione (GSH). In this context, we describe herein the development of a GSH-responsive delivery system based on poly(ethylene glycol)- (PEG-) capped MSNs that are able to deliver safranin O and doxorubicin in a controlled manner. The results showed that the PEG-capped systems designed in this work can be maintained closed at low GSH concentrations, yet the cargo can be delivered when the concentration of GSH is increased. Moreover, the efficacy of the PEG-capped system in delivering the cytotoxic agent doxorubicin in cells was also demonstrated.

year	journal	country	edition	language
2015-03-06

10.1021/acs.langmuir.5b00139 http://hdl.handle.net/10251/64798