Towards chemical communication between gated nanoparticles.

2014

The design of comparatively simple and modularly configurable artificial systems able to communicate through the exchange of chemical messengers is, to the best of our knowledge, an unexplored field. As a proof-of-concept, we present here a family of nanoparticles that have been designed to communicate with one another in a hierarchical manner. The concept involves the use of capped mesoporous silica supports in which the messenger delivered by a first type of gated nanoparticle is used to open a second type of nanoparticle, which delivers another messenger that opens a third group of gated nanoobjects.We believe that the conceptual idea that nanodevices can be designed to communicate with …

Self-Immolative Linkers as Caps for the Design of Gated Silica Mesoporous Supports

2016

A new hybrid material based on sulforhodamine-B dye-loaded silica mesoporous nanoparticles capped with a self-immolative gate has been synthesized and characterized. The gated material's controlled release behavior is monitored under different pH conditions. Under acidic and neutral conditions, a low level of dye release is detected. However, at slightly basic pH, significant dye release occurs owing to deprotonation of the phenol moiety in the capping molecule, which results in its disassembly.

Glucose-triggered release using enzyme-gated mesoporous silica nanoparticles.

2013

[EN] A new gated nanodevice design able to control cargo delivery using glucose as a trigger and cyclodextrin-modified glucose oxidase as a capping agent is reported.

Frontispiece: Self-Immolative Linkers as Caps for the Design of Gated Silica Mesoporous Supports

2016

Influence of lipids on blood and plasma viscosity.

2014

Amparo Vayaa,∗, Cristina Gimeneza, Rafael Alisb,c, Julian Muradoa and Oscar Fustera aHemorheology and Haemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain bResearch Universitary Institute “Dr. Vina Giner”, Molecular and Mitochondrial Medicine, Catholic University of Valencia “San Vicente Martir”, Valencia, Spain cFaculty of Medicine, Catholic University of Valencia “San Vicente Martir”, Valencia, Spain

Sexual behaviors in male sex workers in Spain: Modulating factors

2013

This study analyzed how the culture of origin, educational level, sexual orientation, and experience of male sex workers may mediate their commercial sexual behaviors. A total of 100 Spanish agency male sex workers were interviewed. Most of them were young men, Latin American, homosexual, and had middle-level education. Our results showed that cultural differences and sexual orientation could influence male sex workers when engaging in sexual behaviors with their clients. Social and health projects with male sex workers may have to take into account sexual myths and taboos related to sexual orientation and cultural differences.

Gender, sexuality and relationships in Young Hispanic people

2016

This study explores the relation between gender differences and sexuality among young Hispanic people. Eight hundred and forty young people from Spain and Mexico filled out a self-administered questionnaire about sexuality (sexual experience, sexual orientation, and sexual relationships) and gender (self-identification). Men in both Spain and Mexico more commonly report the practice of masturbation and vaginal sex, and are more likely to be unfaithful than women. Women in both countries report more steady partners and longer length of relationships. There were greater gender differences for Mexican men and women than for Spanish men and women in terms of sexual frequency, sexual orientation…

Über den chemischen Informationsaustausch zwischen gesteuerten Nanopartikeln

2014

Das Design von vergleichsweise einfachen und modular konfigurierbaren k nstlichen Systemen, die ber den Austausch von chemischen Botenstoffen miteinander kommunizieren kçnnen, ist unseres Wissens ein bislang unerforschtes Gebiet. In einer grundlegenden Arbeit pr sentieren wir hier eine Serie von Nanopartikeln, die in hierarchischer Art und Weise miteinander kommunizieren kçnnen. Das Konzept beruht auf gedeckelten mesoporçsen Silikat-Tr gern, bei denen der aus einem ersten Typ von gesteuerten Nanopartikeln freigesetzte chemische Botenstoff einen zweiten Typ von gedeckelten Nanopartikeln çffnet, welche wiederum einen anderen Botenstoff freisetzen, die eine dritte Gruppe von gesteuerten Nanoob…

Selective and Sensitive Chromofluorogenic Detection of the Sulfite Anion in Water Using Hydrophobic Hybrid Organic-Inorganic Silica Nanoparticles

2013

[EN] In water and wine: Chromofluorogenic detection of the sulfite anion in pure water was accomplished by using a new hybrid organic-inorganic material that contained a probe entrapped in hydrophobic biomimetic cavities. This material was used for the detection of sulfite in red wine. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells

2015

In recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming common issues such as poor water solubility and poor stability of some drugs. In particular, redox-responsive delivery systems have attracted the attention of scientists because of the intracellular reductive environment related to a high concentration of glutathione (GSH). In this context, we describe herein the development of a GSH-responsive delivery system based on poly(ethylene glycol)- (PEG-)…