Search results for "LIBRARY"

De la cornette au stéthoscope : Histoire infirmière et dimension du sacré

2012

Au travers les siècles qui ont façonné la relation du soin, les hommes et les femmes ont construit la pratique soignante. La charité et l'engagement, ont donné une consistance à une dimension sacrée de la relation. L'histoire de la pensée soignante permet d'appréhender le sens implicite d'une réalité contemporaine d'abord tournée vers l'opérationnalité. Savoir d'où l'on vient c'est savoir qui on est. Chercher à décrypter son histoire professionnelle peut permettre de comprendre ses racines ou plus simplement, de rendre lisible un message perdu aux origines d'un métier.

The diversity of coordination chemistry – A special issue in honor of Prof. Pierre Braunstein

2017

International audience

Cloning and expression of two novel aldo-keto reductases fromDigitalis purpurealeaves

2002

The aldo-keto reductase (AKR) superfamily comprises proteins that catalyse mainly the reduction of carbonyl groups or carbon–carbon double bonds of a wide variety of substrates including steroids. Such types of reactions have been proposed to occur in the biosynthetic pathway of the cardiac glycosides produced by Digitalis plants. Two cDNAs encoding leaf-specific AKR proteins (DpAR1 and DpAR2) were isolated from a D. purpurea cDNA library using the rat Δ4-3-ketosteroid 5β-reductase clone. Both cDNAs encode 315 amino acid proteins showing 98.4% identity. DpAR proteins present high identities (68–80%) with four Arabidopsis clones and a 67% identity with the aldose/aldehyde reductase from Medi…

Putative multiadhesive protein from the marine spongeGeodia cydonium: Cloning of the cDNA encoding a fibronectin-, an SRCR-, and a complement control…

1998

Sponges (Porifera) representing the simplest metazoan phylum so far have been thought to possess no basal lamina tissue structures. One major extracellular matrix protein that is also a constitutive glycoprotein of the basal lamina is fibronectin. It was the aim of the present study to identify the native protein from the marine sponge Geodia cydonium and to isolate the corresponding cDNA. In crude extracts from this sponge protein(s) of Mr of Ý230 and Ý210 kDa could be visualized by Western blotting using an anti-fibronectin [human] antibody. By PCR cloning from a cDNA library of G. cydonium we isolated a cDNA comprising one element of fibronectin, the type-III (FN3) module. The cDNA (2.3 …

Theoretical studies on cycloaddition reactions

2014

Cycloaddition reactions represent one of the most powerful processes in organic chemistry. The most common types of cycloaddition reactions are the Diels-Alder (DA) and the 1,3-dipolar cycloaddition reactions (1,3-DCs) which lead to five and six membered rings, respectively. In our ongoing efforts to contribute to the understanding of DA and 1,3-DCs; we studied the following using the B3LYP/6-31G(d) level of theory: 1. The 1,3-DCs of the pyridinium-3-olates and pyrazinium-3-olates with methyl acrylate and methyl methacrylate [1,2]. 2. The competitive hetero-DA and 1,3-DCs of methyl glyoxylate oxime and its tautomeric nitrone with cyclopentadiene in the absence and in the presence of BF3 as …

Combinatorial chemistry of  -hairpins

2000

Combinatorial chemistry is expanding rapidly both in terms of chemistry development and application to the synthesis of compound libraries for lead discovery and optimization. Combinatorial technologies continue evolving and developing, in fact they are being used as basic research tools in different fields that include peptide/protein folding. This review examines the use of combinatorial chemistry in the design of peptides and protein domains that adopt beta-sheet conformations. In particular, the use of conformationally restricted peptide libraries has allowed the identification of linear peptides that are folded in a beta-hairpin structure in plain aqueous solutions.

Targeting the Mitochondria by Novel Adamantane-Containing 1,4-Dihydropyridine Compounds

2012

Linda Klimaviciusa1, Maria A. S. Fernandes2, Nelda Lencberga1, Marta Pavasare1, Joaquim A. F. Vicente2, Antonio J. M. Moreno2, Maria S. Santos3, Catarina R. Oliveira4, Imanta Bruvere5, Egils Bisenieks5, Brigita Vigante5 and Vija Klusa1 1Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga 2IMAR-CMA, Department of Life Sciences, University of Coimbra, Coimbra 3CNC, Department of Life Sciences, University of Coimbra, Coimbra 4CNC, Faculty of Medicine, University of Coimbra, Coimbra 5Laboratory of Membrane Active and beta-Diketone Compounds, Latvian Institute of Organic Synthesis, Riga 2,3,4Portugal 1,5Latvia

DOCS ICI, COURTS LÀ : UNE ALTERNATIVE DE DIFFUSION POUR LES FILMS REGIONAUX EN BOURGOGNE-FRANCHE-COMTÉ ?

2021

sous la direction de Christel Taillibert, Jean-Paul Aubert et de Cyril Laverger; International audience; Docs ici, courts là est un dispositif qui valorise les courts métrages et les documentaires produits et/ou réalisés en Bourgogne-Franche-Comté. À travers cette étude de cas, l’auteure rend compte de ses observations et de ses questionnements sur la portée alternative de ce dispositif qui se décline à plusieurs niveaux. Il est complémentaire ou alternatif aux modes de diffusion de films standards (salles de cinéma, festivals, télévision), lorsque les œuvres sont projetées dans des lieux « atypiques ». Mais sa portée alternative se révèle sur d’autres de ses aspects et actions qu’il met en…

Information literacy as a resource for citizenship : an interdisciplinary issue for information studies

2010

Factores facilitadores y barreras en la transición a la ciencia abierta: perspectiva de los agentes del sistema científico español

2022

This paper presents the results of a research study whose objective was to identify the facilitating factors and barriers that, in the opinion of representatives of the Spanish scientific community, impact the implementation of the new open science model in four areas: open access, open research data, research assessment and open peer review. A qualitative study was designed in which information was obtained through interviews with researchers, editors of scientific journals, representatives of assessment agencies and vice-chancellors, and through a focus group of librarians with expertise in aspects of open science. The enabling factors and barriers identified were related to the researche…