6533b7d5fe1ef96bd1264fea
RESEARCH PRODUCT
Combinatorial chemistry of -hairpins
Enrique Pérez-payáEnrique Pérez-payáM. Teresa Pastorsubject
chemistry.chemical_classificationPeptidomimeticChemistryOrganic ChemistryProtein domainPeptideGeneral MedicineCombinatorial chemistryCatalysisPeptide ConformationInorganic ChemistryProtein structureBasic researchDrug DiscoveryProtein foldingPhysical and Theoretical ChemistryPeptide libraryMolecular BiologyInformation Systemsdescription
Combinatorial chemistry is expanding rapidly both in terms of chemistry development and application to the synthesis of compound libraries for lead discovery and optimization. Combinatorial technologies continue evolving and developing, in fact they are being used as basic research tools in different fields that include peptide/protein folding. This review examines the use of combinatorial chemistry in the design of peptides and protein domains that adopt beta-sheet conformations. In particular, the use of conformationally restricted peptide libraries has allowed the identification of linear peptides that are folded in a beta-hairpin structure in plain aqueous solutions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-01-01 | Molecular Diversity |