Search results for "LIBRARY"

La vulgarisation des sciences : fausse "traduction" et vraie "interprétation

2010

International audience; Penser la vulgarisation des sciences comme une simple traduction d'un langage savant en un langage vulgaire conduit à endormir la Société sur l'acte de vulgariser, sur son inventivité et sur sa fonction sociétale. Cet article analyse d'abord comment cette conception, que l'on peut considérer comme une conception-écran, s'appuie sur des prémisses historiques et épistémologiques à revisiter pour, ensuite, interroger les conséquences de son (nécessaire) renversement copernicien.

Beyond the Cultural Turn: A Critical Perspective on Culture-Discourse within Public Relations

2017

International audience; In 1992, Sriramesh and White (1992) pointed to the importance of culture for public relations. Two decades later, public relations scholars had answered their call in force (e.g., Bardhan & Weaver, 2011; Carayol & Frame, 2012; Edwards & Hodges, 2011; Sriramesh & Vercic, 2012). Sriramesh and other PR scholars have criticized much previous public relations research for its focus on the work of Hofstede and cultural characteristics that are apparently common across countries (Sriramesh, 2009), rather than approaches which present culture as a social phenomenon on the level of the social group (Frame, 2012), or as a communication resource or tool-kit (Swidler, 1986). Sri…

Digitization Practice in Latvia: Achievements and Trends of Development

2011

The 1980s are characterized by rapid development of digitization process and research of digital libraries. In 1994 Latvia was also involved in this process with the first attempt to digitize the materials of high demand and in poor physical condition at the Latvian Academic Library. In 1998 the digitization process was launched at the National Library of Latvia. The study, the first results of which are presented in this publication, is made to analyze the history of digitization in Latvia, and to evaluate the achievements of these activities. Up to now the development of digitization process has been poorly documented, therefore the empirical sources are unpublished documents (project rep…

2020

Abstract Information technology (IT) engagement is defined as a need to spend more time using IT. Practice-based examples show that IT engagement can have adverse effects in organizations. Although users can potentially get more work done through IT engagement, observations show that the users might jeopardize their well-being and hamper their work performance. We aimed to investigate this complexity in the research on IT engagement by examining its potential antecedents and outcomes in organizations. Considering the potentially mixed outcomes, we developed a model to examine the effects of IT engagement on personal productivity and strain. We also aimed to explain the antecedents of IT eng…

Customer’s role in knowledge management and in the innovation process: effects on innovation capacity and marketing results

2016

Scholars have acknowledged customer knowledge management (CKM) as a key strategic resource for improving innovation and supporting long-term customer relationship management. This study provides a deeper understanding of the internal antecedents of business innovation capacity overcoming previous approaches. A model that had not previously been tested was used to analyse the role of customer collaboration and CKM – measured as a second-order construct – in innovation processes and marketing results. To test the model, structural equation modelling (partial least squares) was applied to a random sample of 210 Spanish companies. Results confirm that CKM and customer collaboration are antecede…

Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors.

2011

Reliable and effective virtual high-throughput screening (vHTS) methods are desperately needed to minimize the expenses involved in drug discovery projects. Here, we present an improvement to the negative image-based (NIB) screening: the shape, the electrostatics, and the solvation state of the target protein’s ligand-binding site are included into the vHTS. Additionally, the initial vHTS results are postprocessed with molecular mechanics/generalized Born surface area (MMGBSA) calculations to estimate the favorability of ligand-protein interactions. The results show that docking produces very good early enrichment for phosphodiesterase-5 (PDE-5); however, in general, the NIB and the ligand-…

Post-Translational Regulation of CYP450s Metabolism As Revealed by All-Atoms Simulations of the Aromatase Enzyme.

2019

Phosphorylation by kinases enzymes is a widespread regulatory mechanism able of rapidly altering the function of target proteins. Among these are cytochrome P450s (CYP450), a superfamily of enzymes performing the oxidation of endogenous and exogenous substrates thanks to the electron supply of a redox partner. In spite of its pivotal role, the molecular mechanism by which phosphorylation modulates CYP450s metabolism remains elusive. Here by performing microsecond-long all-atom molecular dynamics simulations, we disclose how phosphorylation regulates estrogen biosynthesis, catalyzed by the Human Aromatase (HA) enzyme. Namely, we unprecedentedly propose that HA phosphorylation at Y361 markedl…

MIF from mussel: coding sequence, phylogeny, polymorphism, 3D model and regulation of expression.

2012

Abstract Three macrophage migration inhibitory factor (MIF)-related sequences were identified from a Mytilus galloprovincialis EST library. The consensus sequence included a 5′-UTR of 32 nucleotides, the complete ORF of 345 nucleotides, and a 3′-UTR of 349 nucleotides. As for other MIFs, M. galloprovincialis ORF does not include any signal or C-terminus extensions. The translated sequence of 115 amino acids possesses a molecular mass of 12,681.4, a pI of 6.27 and a stability index of 21.48. Its 3D structure resembles human MIF except for one shorter α-helix. Although evolutionary separated from ticks and vertebrates, Mg-MIF appeared to be closely related to Pinctada fucata and Haliotis, but…

Distinct Photophysics of the Isomers of B18H22 Explained

2012

The photophysics of the two isomers of octadecaborane(22), anti- and syn-B 18H 22, have been studied by UV-vis spectroscopic techniques and theoretical computational methods. In air-saturated hexane, anti-B 18H 22 shows fluorescence with a high quantum yield, Φ F = 0.97, and singlet oxygen O 2( 1Δ g) production (Φ Δ ∼ 0.008). Conversely, isomer syn-B 18H 22 shows no measurable fluorescence, instead displaying much faster, picosecond nonradiative decay of excited singlet states. Computed potential energy hypersurfaces (PEHs) for both isomers rationalize these data, pointing to a deep S 1 minimum for anti-B 18H 22 and a conical intersection (CI) between its S 0 and S 1 states that lies 0.51 e…

Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe

2021

Uniparentally-inherited markers on mitochondrial DNA (mtDNA) and the non-recombining regions of the Y chromosome (NRY), have been used for the past 30 years to investigate the history of humans from a maternal and paternal perspective. Researchers have preferred mtDNA due to its abundance in the cells, and comparatively high substitution rate. Conversely, the NRY is less susceptible to back mutations and saturation, and is potentially more informative than mtDNA owing to its longer sequence length. However, due to comparatively poor NRY coverage via shotgun sequencing, and the relatively low and biased representation of Y-chromosome variants on capture assays such as the 1240 k, ancient DNA…