Search results for "LIBRARY"
showing 10 items of 3069 documents
Why the Pirate Party Won the German Election of 2009 or The Trouble With Predictions: A Response to Tumasjan, A., Sprenger, T. O., Sander, P. G., &am…
2011
In their article “Predicting Elections with Twitter: What 140 Characters Reveal About Political Sentiment,” the authors Andranik Tumasjan, Timm O. Sprenger, Philipp G. Sandner, and Isabell M. Welpe (TSSW) the authors claim that it would be possible to predict election outcomes in Germany by examining the relative frequency of the mentions of political parties in Twitter messages posted during the election campaign. In this response we show that the results of TSSW are contingent on arbitrary choices of the authors. We demonstrate that as of yet the relative frequency of mentions of German political parties in Twitter message allows no prediction of election results.
Adapting Cohort-Component Methods to a Microsimulation: A case study
2022
Social scientists generally take United Nations (UN) population projections as the baseline when considering the potential impact of any changes that could affect fertility, mortality or migration, and the UN typically does projections using the cohort-component method (CCM). The CCM technique is computationally simple and familiar to demographers. However, in order to avoid the exponential expansion of complexity as new dimensions of individual difference are added to projections, and to understand the sensitivity of projections to specific conditions, agent-based microsimulations are a better option. CCMs can mask hidden assumptions that are surfaced by the construction of microsimulatio…
Generation of nonlinear current-voltage characteristics. A general method
2002
International audience; A general method allowing to construct nonlinear resistors with arbitrary current-voltage (I-V) characteristics is proposed. The example of a cubic I-V characteristic is presented showing a perfect agreement between the theoretical desired resistor and its electronic realization based on analog multipliers.
A fixed point theorem for G-monotone multivalued mapping with application to nonlinear integral equations
2017
We extend notion and theorem of [21] to the case of a multivalued mapping defined on a metric space endowed with a finite number of graphs. We also construct an example to show the generality of our result over existing results. Finally, we give an application to nonlinear integral equations
Human type I cytokeratin genes are a compact cluster
1997
A YAC clone (211F11) containing approximately 0.5 Mb of human DNA was isolated from a human genomic library by PCR-based screening with cytokeratin (KRT) 13-specific primers. The YAC clone was mapped by FISH to the long arm of chromosome 17 (17q12→q21), a region to which several other type I KRT genes had been mapped previously. We now show by Southern blot hybridization and PFGE analyses that KRT13, 14, 15, and 16 are all contained within YAC clone 211F11. Long-range restriction mapping analysis of clone 211F11 and of two smaller YAC clones that were also isolated with KRT13-specific primers, suggests that KRT13, 14, 15, 16 and their linked type I genes KRT17 and 19, are contained in less …
Sequence and evolution of the gene for the monomeric globin I and its linkage to genes coding for dimeric globins in the insect Chironomus thummi.
1995
We isolated genomic clones containing sequences encoding globins I and IA from a Chironomus thummi thummi genomic library. Three clones contain globin IA (ctt-1A) genes, while one contains a globin I (ctt-1) gene. The coding regions of the four genes are identical except for the single base substitution accounting for the globin I/IA polymorphism. The noncoding DNA flanking the coding region is more than 98% similar, confirming a previous hypothesis that the globin ctt-1 and ctt-1A genes are alleles. Hemoglobins I and IA are monomeric in the insect hemolymph. Earlier in situ hybridization studies suggested that monomeric and dimeric globin genes are clustered at different chromosomal loci. …
Baculoviral display of functional scFv and synthetic IgG-binding domains.
2000
Viral vectors displaying specific ligand binding moities such as scFv fragments or intact antibodies hold promise for the development of targeted gene therapy vectors. In this report we describe baculoviral vectors displaying either functional scFv fragments or the synthetic Z/ZZ IgG binding domain derived from protein A. Display on the baculovirus surface was achieved via fusion of the scFv fragment or Z/ZZ domain to the N-terminus of gp64, the major envelope protein of the Autographa californica nuclear polyhedrosis virus, AcNPV. As examples of scFv fragments we have used a murine scFv specific for the hapten 2-phenyloxazolone and a human scFv specific for carcinoembryonic antigen. In pri…
Distributed and Lumped Parameter Models for the Characterization of High Throughput Bioreactors
2016
Next generation bioreactors are being developed to generate multiple human cell-based tissue analogs within the same fluidic system, to better recapitulate the complexity and interconnection of human physiology. The effective development of these devices requires a solid understanding of their interconnected fluidics, to predict the transport of nutrients and waste through the constructs and improve the design accordingly. In this work, we focus on a specific model of bioreactor, with multiple input/outputs, aimed at gen- erating osteochondral constructs, i.e., a biphasic construct in which one side is cartilagi- nous in nature, while the other is osseous. We next develop a general computat…
Recent advances in the expression, evolution, and dynamics of prokaryotic genomes
2007
Work on the molecular and cellular biology of prokaryotic microorganisms and their phage continues to be at the cutting edge in many areas of fundamental research in the life sciences. An important stimulus has been the large number of complete bacterial and archaeal genome sequences that have appeared over the past decade and that now are being produced at a rate of several hundred per year. This information is the foundation for all of the “-omics” leading to a global evaluation of the state of the cell under various conditions of growth or stress. An overview of the sequenced prokaryotic genomes has also greatly influenced our thinking about the evolution of life on earth. The EMBO Confe…
Minisatellite DNA Probe MZ 1.3: Application in Paternity Testing and Estimate of the Number of Genetic Loci
1990
The use of hypervariable DNA minisatellite probes recognizing repetitive genomic DNA sequences has become a valuable and powerful tool in paternity testing as well as in forensic stain analysis (Jeffreys et al. 1985, 1987; Werrett et al. 1988). It has been shown that bacteriophage Ml3 DNA can also be used to obtain hypervariable DNA restriction fragment patterns in humans and other species (Vassart et al. 1987). To obtain more informative and specific fragment patterns for the DNA ‘fingerprint’ analysis in man, we have used Ml3 DNA as a probe to screen a human genomic library. Thus, we have isolated the minisatellite DNA probe MZ 1.3 (Schacker et al., in press). MZ 1.3 is a 1.9 kb fragment …