Search results for "LIBRARY"

eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.

2017

The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C-¿ (PKC-¿) at the central supramolecular activation cluster (c-SMAC) of the IS. eNOS translocated with the Golgi to the IS and partially colocalized with F-actin around the c-SMAC. This resulted in reduced actin polymerization and centripetal retrograde flow of ß-actin and PKC-¿ from the lamellipodium-like distal (d)-SMAC, promoting PKC-¿ activation. Furthermore, eNOS-derived NO S-nitrosylated ß-…

Digital Storytelling and Multimodal Literacy in Education

2014

This article argues in favour of using digital storytelling to encourage a critical socio-educational focus in education and include multimodal explicit teaching in the curriculum. The analysis of fifty digital stories indicates that the students developed a certain awareness of the issue chosen for their story (e.g. violence, racism, war) since the final product transmits a critical perspective on the topic itself. Further work, however, needs to be invested in the development of the digital story content itself and on the issue of multimodal learning, with especial emphasis on the interface between multimodal elements and more traditional modes of transmitting ideas.

‘Quit Presently the Chapel’: A Note on Setting in the Final Scene of The Winter’s Tale

2020

A List of Family Relation Names from Cambridge, Corpus Christi College 265, p. 112

2020

References to the Doubling of Autolycus and the Bear in Shakespeare’s The Winter’s Tale

2019

Une approche communicationnelle de la professionnalisation au sein des Instituts de formation en soins infirmiers en France

2013

Dans un contexte de fortes mutations et de réflexion autour du devenir des métiers de la santé et de l’appareil de formation qui leur est dédié en France, les formateurs et les directeurs des Instituts de Formation en Soins Infirmiers sont amenés à travailler à la construction et à la promotion du projet pédagogique de leur établissement. Au quotidien, leurs pratiques individuelles montrent combien leur lecture de la réalité de travail est singulière et se trouve en partie corrélée à leur professionnalité. A partir des significations que chacun d’eux exprime, la coopération entre ces professionnels semble se construire très progressivement à la croisée des problématiques communicationnelles…

Time for a Step Change? Improving the Efficiency, Relevance, Reliability, Validity and Transparency of Aphasia Rehabilitation Research through Core O…

2014

Considered and meticulous outcome measurement is central to rigorously conducted effectiveness trials, and in turn the relevance and reliability of the study findings to the patient, therapist or p...

Una propuesta didáctica para la implementación de la atenuación en español para los negocios

2018

El objetivo de este estudio es presentar una propuesta didáctica sobre la enseñanza de la atenuación en el ámbito de Español para los negocios, en Español como Lengua Extranjera. El diseño de esta propuesta tiene dos pilares: el análisis de materiales didácticos de E/LE de acuerdo con el Marco Común Europeo de Referencia en el nivel B1 y también se elabora un estudio de manuales. El resultado del análisis nos sirve para ver la frecuencia con la que se lleva al aula el fenómeno de la atenuación. Después, se propone una secuencia didáctica implementada en la Universitat de València. The aim of this study is to offer a didactic proposal for teaching mitigation in Spanish Business, in Spanish a…

Identification from a Positional Scanning Peptoid Library of in Vivo Active Compounds That Neutralize Bacterial Endotoxins

2005

4 pages, 3 figures, 1 table.-- PMID: 15715495 [PubMed].-- Printed version published Feb 24, 2005.-- Supporting information available at: http://pubs.acs.org/doi/suppl/10.1021/jm040834i

Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell.

2008

Contains fulltext : 70610.pdf (Publisher’s version ) (Closed access) The screening of a commercially available library of compounds has proved a successful strategy for the identification of a lead compound in a drug discovery programme. Here, we analysed 880 off-patent drugs, which initially comprised the Prestwick Chemical library, as sources of bacterial endotoxin neutralizers. We identified 3,3',5-triiodo-thyroacetic acid (tiratricol) as a non-antibacterial compound that neutralizes the toxic lipopolysaccharide.