Search results for "LIOP"
showing 10 items of 1268 documents
Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.
2001
To study the relevance of the terminal alpha,beta-unsaturated gamma-methyl-gamma-lactone moiety of the antitumoral acetogenins of Annonaceae for potent mitochondrial complex I inhibition, we have prepared a series of semisynthetic acetogenins with modifications only in this part of the molecule, from the natural rolliniastatin-1 (1) and cherimolin-1 (2). Some of the hydroxylated derivatives (1b, 1d and 1e) in addition to two infrequent natural beta-hydroxy gamma-methyl gamma-lactone acetogenins, laherradurin (3) and itrabin (4), are more potent complex I inhibitors than any other known compounds.
Mapping the possibilities of contingency theory in organization research : qualitative and quantitative analysis of two small lobbying organizations
2017
Tutkin Pro Gradu-työssäni kahta lobbausorganisaatiota. Suoritin materiaalinkeruun käyttämällä kyselylomaketta vuoden 2014 kevään ja syksyn aikana. Kuvailen materiaalin avulla millaisia organisaatiot ovat ja miten ne toimivat. Lisäksi tutkin materiaalin avulla niitä organisaatioiden ominaisuuksia, jotka vaikuttavat organisaatioiden differentiaatio- ja integraatio tekijöihin. Päätän tutkimukseni analyysiin tärkeimmistä differentiaatio- ja integraatiotekijöistä ja tutkin miten ne vaikuttavat organisaatioihin niiden kohdatessa muutoksia toimintaympäristöissään. Käytän tutkimuksessani kontingenssiteoriaa. Teoriaa ei ole käytetty kovinkaan paljoa sosiologian tai sosiologisen organisaatiotutkimuks…
Sprachenpolitik finnischer Universitäten im Zeitalter strategischer Internationalisierung
2014
The Finnish Ministry of Education expected higher education institutions to draw up language strategies during 2009. The aim of the present study is to explore to what extent this expectation was taken into account by the universities. To investigate the state and contents of the language strategies, archival research and surveys were designed. The research questions were: 1) How many language strategies existed until the beginning of 2014? 2) Is there any evidence for cooperation between universities in language strategy matters? 3) Which languages matter strategically? The results show that until the beginning of 2014, 71 percent of the universities had a language strategy. It appears tha…
Laskennalliset tieteet Suomen yliopistoissa vuonna 2021
2021
The challenge for school-based teacher educators : establishing teaching and supervision goals
2019
School-based teacher educators (SBTEs) should be able to set goals in two roles – as a teacher and as a supervisor of student teachers. The purpose of the study was to investigate school-based teacher educators’ teaching and supervising goals and to identify how teachers in the role of supervisors perceived university expectations. Thematic analysis indicated that teachers have difficulty establishing goals for themselves as teachers and supervisors. Their teaching goals proceeded from curricula and focused on their pupils’ cognitive development, whilst their perceptions about supporting pupils’ social development were vague. Teachers were unaware of what exactly universities expected of th…
Mitt i brytpunkten: Finska universitetsstudenters åsikter om svenskan
2009
A Transition Zone Complex Regulates Mammalian Ciliogenesis and Ciliary Membrane Composition
2011
Mutations in genes encoding ciliary components cause ciliopathies, but how many of these mutations disrupt ciliary function is unclear. We investigated Tectonic1 (Tctn1), a regulator of mouse Hedgehog signaling, and found that it is essential for ciliogenesis in some, but not all, tissues. Cell types that do not require Tctn1 for ciliogenesis require it to localize select membrane-associated proteins to the cilium, including Arl13b, AC3, Smoothened and Pkd2. Tctn1 forms a complex with multiple ciliopathy proteins associated with Meckel (MKS) and Joubert (JBTS) syndromes, including Mks1, Tmem216, Tmem67, Cep290, B9d1, Tctn2, and Cc2d2a. Components of the Tectonic ciliopathy complex colocaliz…
Risultati del trattamento ortottico in bambini di età inferiore ai 10 anni con ambliopia anisometropica.
2015
Typification of the names Anethum pusillum and Meum segetum (Apiaceae)
2022
Recent works (Jimenez-Mejias & Vargas 2015, Frankiewicz et al. 2021) have improved our knowledge about systematics and phylogeny of the Apiaceae: in detail, the Authors suggested the opportunity to merge several genera within Anethum Linnaeus (1753: 263), namely: Foeniculum Miller (1754: [513]), Ridolfia Moris (1841: 43), Pseudoridolfia Reduron, Mathez & S. R. Downie in Reduron et al. (2009: 496), and Schoenoselinum Jimenez-Mejias & Vargas (2015: 75). In this framework, we think that it is important to typify the names Anethum pusillum All. (Allioni 1773: 28) and Meum segetum Guss. (Gussone 1827: 346), both belonging to this “Anethum alliance” (as defined by Jimenez-Mejias &…
The Centaurea parlatoris complex (Asteraceae): taxonomic checklist and typifications
2021
A taxonomic account of the Centaurea parlatoris complex (Asteraceae), endemic to Sicily, is presented. This complex includes six taxa, three described in the 19th century (C. parlatoris, C. parlatoris var. tomentosa and C. parlatoris var. virescens) and three recently described (C. sicana, C. giardinae and C. heywoodiana). Starting from the designation of the types for the oldest plant names that have not been typified yet, taxonomic considerations are formulated and C. parlatoris var. virescens is elevated to the rank of species. An identification key and a distribution map complete this account.