Search results for "LMIC"
showing 10 items of 131 documents
Topical glaucoma medications – Clinical implications for the ocular surface
2022
Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility of the compound. A growing number of clinical and experimental studies report the detrimental effects of not only these preservatives but also the active pharmaceutical compounds on the ocular surface, with resultant tear film instability and dry eye disease. Herein, we critically appraise the published literature exploring the effects of preservatives and pharmaceutical compounds on the ocular surface. publishedVersion
Effect of even and odd-order aberrations on the accommodation response
2017
Aim To investigate the potential effect that odd and even-order monochromatic aberrations may have on the accommodation response of the human eye. Methods Eight healthy subjects with astigmatism below 1 D, best corrected visual acuity 20/20 or better and normal findings in an ophthalmic examination were enrolled. An adaptive optics system was used in order to measure the accommodation response of the subjects' eyes under different conditions: with the natural aberrations being present, and with the odd and even-order aberrations being corrected. Three measurements of accommodation response were monocularly acquired at accommodation demands ranging from 0 to 4 D (0.5 D step). Results The acc…
Carbonic anhydrase inhibitor with topical NSAID therapy to manage cystoid macular edema in a case of gyrate atrophy
2017
Purpose Gyrate atrophy of the choroid and retina (GACR) is a rare chorioretinal dystrophy characterized by a deficiency of the enzyme ornithine aminotransferase, inherited in an autosomal recessive pattern. Case Report We report a case of a 17-year-old girl with GACR, for whom the level of serum ornithine had been reduced by an arginine-restricted diet. The patient was responsive to an association of topical nonsteroidal anti-inflammatory drugs (NSAIDs) and a carbonic anhydrase inhibitor (CAI) to reduce cystoid macular edema (CME). Conclusions The efficacy of topical NSAIDs and systemic CAI association indicates that the imbalance in the distribution of retinal pigment epithelium membrane-b…
Contact lenses: do they really change the opticalperformance?
1996
Abstract In this investigation the quality of two types of optical correction, hydrogel contact lenses and ophthalmic lenses, wascompared by measuring the modulation transferfunction (MTF) of the correcting lens plus visual optics system using an objective method. A merit function was defined in order to allow the direct comparison between the optical performance with the two corrections. A study on 10 subjects was undertaken, measuring the MTF of both corrections by using the double pass method. The results show that the optical quality of contact lenses was higher than that with ophthalmic lenses. The contrast sensitivity function (CSF) and visual acuity (VA) were determined as subjective…
Rheology of Sodium Hyaluronate Saline Solutions for Ophthalmic Use
2007
The aim of this work was to investigate the rheological properties of different saline solutions of sodium hyaluronate (NaHA) with special interest for medical applications. The experimental results were compared with literature data for commercial ophthalmic viscosurgical devices (OVDs) used in cataract surgery. We offer some tools to tailor the rheological behavior of OVDs for different purposes. We have investigated to which extent surgical requirements can be fulfilled by adjusting either the molecular weight of NaHA or its concentration, parameters that are in some respects equivalent but not in others. Furthermore, we demonstrate that moduli and complex viscosities of NaHA saline solu…
La aldea maldita y la cultura fin de siglo
2004
Este artículo pretende ser una reflexión sobre la posible influencia de la literatura y sobre todo de las artes plásticas-fotografía del fin de siglo y aledaños, en una de las películas españolas más apreciadas del período silente. El análisis se inscribe por tanto en esa amplia esfera de constante interrelación entre el cine y el resto de disciplinas artísticas, en la que quedan todavía muchos caminos por explorar. (A)
Role of nitric oxide synthase isoforms for ophthalmic artery reactivity in mice.
2014
Abstract Nitric oxide synthases (NOS) are involved in regulation of ocular vascular tone and blood flow. While endothelial NOS (eNOS) has recently been shown to mediate endothelium-dependent vasodilation in mouse retinal arterioles, the contribution of individual NOS isoforms to vascular responses is unknown in the retrobulbar vasculature. Moreover, it is unknown whether the lack of a single NOS isoform affects neuron survival in the retina. Thus, the goal of the present study was to examine the hypothesis that the lack of individual nitric oxide synthase (NOS) isoforms affects the reactivity of mouse ophthalmic arteries and neuron density in the retinal ganglion cell (RGC) layer. Mice defi…
Pandemónium. La filmografía de Román Chalbaud en el cine venezolano. Contexto y análisis
2015
El presente trabajo tiene como objetivo identificar algunos de los principios compositivos que rigen las diversas propuestas narrativas, conceptuales y estilísticas en el filme Pademónium. La capital del infierno (Román Chalbaud, Venezuela, 1997), en particular a través del análisis de la puesta en escena y sus registros, con el fin de establecer algunos elementos comunes o dominantes en la carrera como realizador cinematográfico del autor, así como algunas relaciones existentes entre sus películas y el contexto en el cual fueron producidas. Para ello, en el primer capítulo se lleva a cabo un recuento histórico del estado del cine venezolano desde la llegada al país del cinematógrafo hasta …
Do Women in Nepal Like Playing a Mobile Game? MANTRA: A Mobile Gamified App for Improving Healthcare Seeking Behavior in Rural Nepal
2021
In Low and Middle Income Countries (LMIC), one of the causes of maternal and child mortality is a lack of medical knowledge and consequently the inability to seek timely healthcare. Mobile health (mHealth) technology is gradually becoming a universal intervention platform across the globe due to ubiquity of mobile phones and network coverage. MANTRA is a novel mHealth intervention developed to tackle maternal and child health issues through a serious mobile game app in rural Nepal, which demonstrated a statistically significant knowledge improvement in rural women. This paper explores the perceptions and usability of the MANTRA app amongst rural women and Female Community Health Volunteers …