Search results for "LOCALIZATION"
showing 10 items of 443 documents
Variability in human hepatic MRP4 expression: influence of cholestasis and genotype
2007
The multidrug resistance protein 4 (MRP4) is an efflux transporter involved in the transport of endogenous substrates and xenobiotics. We measured MRP4 mRNA and protein expression in human livers and found a 38- and 45-fold variability, respectively. We sequenced 2 kb of the 5'-flanking region, all exons and intron/exon boundaries of the MRP4 gene in 95 patients and identified 74 genetic variants including 10 non-synonymous variations, seven of them being located in highly conserved regions. None of the detected polymorphisms was significantly associated with changes in the MRP4 mRNA or protein expression. Immunofluorescence microscopy indicated that none of the non-synonymous variations af…
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes
2012
One mechanism by which disease-associated DNA variation can alter disease risk is altering gene expression. However, linkage disequilibrium (LD) between variants, mostly single-nucleotide polymorphisms (SNPs), means it is not sufficient to show that a particular variant associates with both disease and expression, as there could be two distinct causal variants in LD. Here, we describe a formal statistical test of colocalization and apply it to type 1 diabetes (T1D)-associated regions identified mostly through genome-wide association studies and expression quantitative trait loci (eQTLs) discovered in a recently determined large monocyte expression data set from the Gutenberg Health Study (1…
Binaural release from masking in forward-masked intensity discrimination: Evidence for effects of selective attention
2012
In a forward-masked intensity discrimination task, we manipulated the perceived lateralization of the masker via variation of the interaural time difference (ITD). The maskers and targets were 500 Hz pure tones with a duration of 30 ms. Standards of 30 and 60 dB SPL were combined with 60 or 90 dB SPL maskers. As expected, the presentation of a forward masker perceived as lateralized to the other side of the head as the target resulted in a significantly smaller elevation of the intensity difference limen than a masker lateralized ipsilaterally. This binaural release from masking in forward-masked intensity discrimination cannot be explained by peripheral mechanisms because varying the ITD l…
Immunohistological and immunoelectron microscopic identification of TNF alpha in normal human and murine epidermis.
1992
The presence, distribution and cellular localization of tumour necrosis factor-alpha (TNF alpha) were investigated in normal human and murine epidermis using immunohistological and immunoelectron microscopic methods with monoclonal and polyclonal antibodies. The immunostaining revealed an intercellular plasma membrane and cytoplasmic labelling of the epidermal keratinocytes, but no labelling of Langerhans cells, melanocytes and Merkel cells. Large amounts of TNF alpha were regularly found in the sebaceous glands. These findings demonstrate that epidermal keratinocytes and especially sebocytes produce and release TNF alpha and that this keratinocyte-derived cytokine may be important for the …
Morphological Alterations and Stress Protein Variations in Lung Biopsies Obtained from Autopsies of COVID-19 Subjects
2021
Molecular chaperones, many of which are heat shock proteins, play a role in cell stress response and regulate the immune system in various ways, such as in inflammatory/autoimmune reactions. It would be interesting to study the involvement of these molecules in the damage done to COVID-19-infected lungs. In our study, we performed a histological analysis and an immunomorphological evaluation on lung samples from subjects who succumbed to COVID-19 and subjects who died from other causes. We also assessed Hsp60 and Hsp90 distribution in lung samples to determine their location and post-translational modifications. We found histological alterations that could be considered pathognomonic for CO…
Single-Sided Deafness: Impact of Cochlear Implantation on Speech Perception in Complex Noise and on Auditory Localization Accuracy.
2017
Objective To assess auditory localization accuracy and speech reception threshold (SRT) in complex noise conditions in adult patients with acquired single-sided deafness, after intervention with a cochlear implant (CI) in the deaf ear. Study design Nonrandomized, open, prospective patient series. Setting Tertiary referral university hospital. Patients Eleven patients with late-onset single-sided deafness (SSD) and normal hearing in the unaffected ear, who received a CI. All patients were experienced CI users. Intervention Unilateral cochlear implantation. Main outcome measures Speech perception was tested in a complex multitalker equivalent noise field consisting of multiple sound sources. …
The Electronic Structure of Hexagonal BaCoO3
1999
Abstract TB–LMTO–ASA band structure calculations within the local spin density approximation have been performed to explain the magnetic and transport properties of BaCoO3. The calculations predict a magnetic and metallic ground state as energetically favored. BaCoO3 shows no long-range magnetic ordering, however, and only poor conductivity. The magnetic energy is low and the compound shows glassy susceptibility behavior at low temperatures. From the band structure we find Mott–Hubbard localization to be unlikely, and instead propose Anderson localization as a possible origin of the observed behavior. Calculations on slightly distorted structures exclude the possibility of a Peierls distort…
Polar bosons in one-dimensional disordered optical lattices
2013
We analyze the effects of disorder and quasi-disorder on the ground-state properties of ultra-cold polar bosons in optical lattices. We show that the interplay between disorder and inter-site interactions leads to rich phase diagrams. A uniform disorder leads to a Haldane-insulator phase with finite parity order, whereas the density-wave phase becomes a Bose-glass at very weak disorder. For quasi-disorder, the Haldane insulator connects with a gapped generalized incommesurate density wave without an intermediate critical region.
NMR Spectroscopic Evidence for the Intermediacy of XeF3− in XeF2/F− Exchange, Attempted Syntheses and Thermochemistry of XeF3− Salts, and Theoretical…
2010
The existence of the trifluoroxenate(II) anion, XeF(3)(-), had been postulated in a prior NMR study of the exchange between fluoride ion and XeF(2) in CH(3)CN solution. The enthalpy of activation for this exchange, ΔH(⧧), has now been determined by use of single selective inversion (19)F NMR spectroscopy to be 74.1 ± 5.0 kJ mol(-1) (0.18 M) and 56.9 ± 6.7 kJ mol(-1) (0.36 M) for equimolar amounts of [N(CH(3))(4)][F] and XeF(2) in CH(3)CN solvent. Although the XeF(3)(-) anion has been observed in the gas phase, attempts to prepare the Cs(+) and N(CH(3))(4)(+) salts of XeF(3)(-) have been unsuccessful, and are attributed to the low fluoride ion affinity of XeF(2) and fluoride ion solvation in…
Localisation visuelle basée sur la reconnaissance du lieu dans les environnements changeants
2017
In many applications, it is crucial that a robot or vehicle localizes itself within the world especially for autonomous navigation and driving. The goal of this thesis is to improve place recognition performance for visual localization in changing environment. The approach is as follows: in off-line phase, geo-referenced images of each location are acquired, features are extracted and saved. While in the on-line phase, the vehicle localizes itself by identifying a previously-visited location through image or sequence retrieving. However, visual localization is challenging due to drastic appearance and illumination changes caused by weather conditions or seasonal changing. This thesis addres…