Search results for "LOCI"
showing 10 items of 1277 documents
Detection, validation, and downstream analysis of allelic variation in gene expression.
2009
AbstractCommon sequence variants within a gene often generate important differences in expression of corresponding mRNAs. This high level of local (allelic) control—or cis modulation—rivals that produced by gene targeting, but expression is titrated finely over a range of levels. We are interested in exploiting this allelic variation to study gene function and downstream consequences of differences in expression dosage. We have used several bioinformatics and molecular approaches to estimate error rates in the discovery of cis modulation and to analyze some of the biological and technical confounds that contribute to the variation in gene expression profiling. Our analysis of SNPs and alter…
piRNAclusterDB 2.0: update and expansion of the piRNA cluster database.
2021
Abstract PIWI-interacting RNAs (piRNAs) and their partnering PIWI proteins defend the animal germline against transposable elements and play a crucial role in fertility. Numerous studies in the past have uncovered many additional functions of the piRNA pathway, including gene regulation, anti-viral defense, and somatic transposon repression. Further, comparative analyses across phylogenetic groups showed that the PIWI/piRNA system evolves rapidly and exhibits great evolutionary plasticity. However, the presence of so-called piRNA clusters as the major source of piRNAs is common to nearly all metazoan species. These genomic piRNA-producing loci are highly divergent across taxa and critically…
Trasporto pubblico su gomma in ambito urbano: un modello per la stima della velocità commerciale e della velocità origine-destinazione
2011
Un esperimento sulla distribuzione di velocità degli elettroni in una valvola termoionica
2012
In questo lavoro è discusso un approccio sperimentale alla distribuzione di Maxwell- Bolzmann. A partire dallo studio delle caratteristiche I-V dei triodi a vuoto, si perviene, utilizzando un semplice modello, alla distribuzione di velocità degli elettroni emessi dal catodo dei dispositivi utilizzati. L’esperimento qui proposto può aiutare gli studenti a focalizzare l’attenzione sul concetto di distribuzione di velocità in un sistema di particelle, senza distrarli dalle difficoltà concettuali connesse alla complessità del fenomeno dell’emissione termoionica.
Long-lived Rossby wave trains as precursors to strong winter cyclones over Europe
2013
The statistical connection between strong surface cyclones over Europe and long-lived upper-tropospheric Rossby wave trains is examined for the Northern Hemisphere winter season using 45 years of reanalysis data. Dates are selected for which the surface pressure anomaly over Central Europe is below a threshold yielding the 5% of lowest values. Composites of upper tropospheric meridional wind for these dates (including a lead or lag in time) display clear signs of a wave train. The composite wave train lives for over two weeks and propagates eastward over more than 360° longitude. The phase speed of individual lows and highs, by contrast, is close to zero and the same is true for the composi…
Comparative Study of Different Column Types for the Separation of Polar Basic Hallucinogenic Alkaloids
2016
The number of hallucinogenic compounds that have been separated simultaneously by liquid chromatography is limited. This research aimed to identify a column(s) that can allow for separation of several hallucinogens. The extent of separation of seven polar hallucinogenic tryptamine and phenethylamine derived alkaloids containing a basic N atom that becomes protonated at low pH values were investigated on five reverse-based columns and one hydrophilic interaction liquid chromatography (HILIC) column. An RP-phenyl and a negatively charged fused core HILIC were identified and recommended as effective columns in this regard. This research is the first to introduce a HILIC column in separation of…
Analysing longitudinal turbulence intensity in vegetated channels
2007
Vegetation altering hydrodynamic conditions of an open channel flow controls the exchanges of sediment, nutrients and contaminants. In this paper the turbulence structure of open-channel flow over a flexible grass vegetation is investigated. Velocity measurements were carried out, in a rectangular flume, using a 2D-ADV (Acoustic Doppler Velocimeter) for different values of stem concentration, water discharge, and bed slope. The experimental results showed that: 1) the maximum value of the longitudinal turbulence intensity occurs at a water depth close to the bent vegetation height; 2) the turbulence intensity damps for increasing values of the stem concentration; 3) above the vegetation hei…
Spectral classification & physical parameters of the IPHAS CBe stars in the BCD system.
2017
The INT Photometric Hα Survey (IPHAS) has detected tens of thousands of emission line objects in the Northern Galactic Plane. Spectroscopic follow-up has shown that the vast majority of them are Classical Be (CBe) stars, rapidly rotat- ing main sequence B type stars which develop an outflowing circumstellar disk by mechanisms not yet completely understood. In this work we present a study of the full catalogue of the CBe stars discovered by IPHAS. We have analyzed 805 low resolution spectra of 732 IPHAS CBe stars. With a semi-automatic proce- dure, which we evaluate at the first part of this work, we obtained the relevant physical parameters, including the effective temperature, surface grav…
Identificación temprana de los predictores de las habilidades implicadas en el desarrollo del aprendizaje de la escritura
2017
La escritura es una habilidad fundamental que utilizamos de forma cotidiana desde apuntar una nota hasta redactar un mensaje o una carta, pero es una destreza muy compleja porque exige atender a varios aspectos simultáneamente. A pesar de la importancia de la habilidad escritora, un análisis de la literatura focalizada en la detección de los procesos cognitivos que están a la base del aprendizaje de la misma, ha permitido subrayar que la atención a ella dirigida no ha sido hasta ahora la suficiente. Aun así, se han detectado algunos predictores del desarrollo de las habilidades fonológico-ortográficas necesarias en el aprendizaje de la lectura, cuya cercanía y fuerte relación con la escritu…
Management of the image of the city in urban planning: experimental methodologies in the colour plan of the Egadi Islands
2022
AbstractThe debate over the value of the image of a city, which since the 1960s has been gaining wider room for reflection, has arisen as a criticism against the reductionism of the Modern Movement and highlighted the value of the qualitative aspects of an urban landscape. The question asked is if urban planning can in some way govern the image of a city. An investigation into which tools and strategies are necessary to defend the narrative of a city, its identity and its genius loci against the homologating forces that are transforming contemporary cities. The article explores the theoretical principles and methods being experimentally used to qualitatively manage the urban environment. Re…