Search results for "LOCUS"

The PAI-1 gene locus 4G/5G polymorphism is associated with a family history of coronary artery disease.

1998

Abstract —A family history of ischemic events is a major determinant of coronary artery disease (CAD). Plasma levels of plasminogen activator inhibitor 1 (PAI-1) modulate this risk. A deletion/insertion polymorphism within the PAI-1 locus (4G/5G) affects the expression of this gene. We investigated the relationship between the PAI-1 4G/5G polymorphism in 1179 healthy employees of our institution and the occurrence of CAD in their first-degree relatives. A family history of documented ischemic coronary disease was assessed by a modified WHO questionnaire. The PAI-1 4G/5G polymorphism was evaluated by polymerase chain reaction and endonuclease digestion. The group with a first-degree relativ…

Spectroscopic axonal damage of the right locus coeruleus relates to selective attention impairment in early stage relapsing-remitting multiple sclero…

2003

Summary Lower levels of N-acetylaspartate (NAA), a marker of axonal damage, have been found in the normal-appearing white matter (NAWM) of relapsing-remitting multiple sclerosis (RRMS) patients with low physical disability. However, its relation to the clinical status of these patients remains unclear. We explored the association between NAA levels [normalized to creatine (Cr), NAA/Cr] and a cognitive feature that is not measured by the standard scales that address functional disability [e.g. Expanded Disability Scale Score (EDSS)] in early RRMS. Given that a considerable number of RRMS patients present attentional dysfunction early in the disease and assuming a functional-anatomical orient…

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.

2009

Context Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease. Objective To identify common genetic variants associated with cardiac structure and function by conducting a meta-analysis of genome-wide association data in 5 population-based cohort studies (stage 1) with replication (stage 2) in 2 other community-based samples. Design, Setting, and Participants Within each of 5 community-based cohorts comprising the EchoGen consortium (stage 1; n = 12 612 individuals of European ancestry; 55% women, aged 26-95 years; examinations between 1978-2008), we estimated the association between approximately 2.5 million single-nuc…

A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol

2012

Serum lipid levels have been associated with cardiovascular diseases, metabolic syndrome and type II diabetes (Kannel et al., 1961; Miller & Miller, 1975; Pilia et al., 2006). Variation in lipids levels is highly influenced by heritable factors (Friedlander et al., 1997) and 95 loci have already been associated with levels of high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides (TG) and total cholesterol (TC) in numerous study samples and replicated in various populations using genome-wide approaches (Aulchenko et al., 2008; Kathiresan et al., 2008; Kooner et al., 2008; Teslovich et al., 2010; Willer et al., 2008). However, the genetic associa…

A questionnaire assessing women's care needs related to gynaecological cancer screening: development of the GCSCNS.

2013

Abstract Objective To identify women's care needs concerning cancer screening and to develop an instrument suitable for measuring them – the Gynaecological Cancer Screening Care Needs Scale (GCSCNS). We hypothesized that it is possible: (a) to explore care needs and to develop reliable subscales of them, (b) to rank these needs in order of importance, and (c) to detect determinants of these needs (age, social status, marital status, health locus of control) and these need scores. Study design A questionnaire was developed based on the relevant literature, interviews conducted with gynaecological patients, and a consultation with 18 experts. The questionnaire listed 58 items addressed to phy…

Major histocompatibility complex and sporadic Alzheimer's disease: a critical reappraisal

2003

Epidemiological data suggest that some genetic determinants of Alzheimer's disease (AD) might reside in those polymorphisms for the immune system genes that regulate immune inflammatory responses, such as the major histocompatibility complex (MHC). Therefore, MHC polymorphisms have been the focus of a large number of AD association studies. Class Ia, Ib (hemochromatosis gene (HFE)), class II and class III (complement, tumour necrosis factor and heat shock proteins) alleles have been studied. Nearly every positive result has been followed by several studies that have failed to replicate it or that have contradicted it. Several factors, including methodological biases, might explain these dis…

2021

Gambling may range from being a recreational leisure activity to a behavioral addiction. A rising number of gamblers experience adverse consequences from gambling, termed problem gambling, which may become a challenge for the individual and society. With the present research, we aimed to investigate the correlates of problem gambling. We used a large sample of more than 12,500 individuals (46% male, Mage = 48, SDage = 18) from the Household, Income, and Labour Dynamics in Australia (HILDA) Survey and analyzed sociodemographic and personality variables (Big Five, locus of control) as well as the extent of problem gambling. Findings showed that male sex and a lower level of education were rel…

PSYCHOLOGY STUDENTS PERSONALITY TRAITS AND MOTIVATION TO CHOOSE STUDIES

2016

The sample consisted of 83 first course academic and professional psychology program students aged 18-43 years. Research instruments: 1) Demographic survey; 2) BFI (Big Five Inventory, Benet – Martinez & John, 1998), adapted version in Latvian (Austers, 2007); 3) The assessment of psychology studies motivation. Key findings: The most important motivating factors for psychology studies in this sample are interest in psychology and the desire to help. Personality traits are related to the choice of profession motives: Agreeableness and Conscientiousness are positively correlated with the desire to help, Extroversion with a sense of capability for the profession, Neuroticism - with a uncer…

Mycotoxin Profile and Phylogeny of Pathogenic Alternaria Species Isolated from Symptomatic Tomato Plants in Lebanon

2021

The tomato is one of the most consumed agri-food products in Lebanon. Several fungal pathogens, including Alternaria species, can infect tomato plants during the whole growing cycle. Alternaria infections cause severe production and economic losses in field and during storage. In addition, Alternaria species represent a serious toxicological risk since they are able to produce a wide range of mycotoxins, associated with different toxic activities on human and animal health. Several Alternaria species were detected on tomatoes, among which the most important are A. solani, A. alternata, and A. arborescens. A set of 49 Alternaria strains isolated from leaves and stems of diseased tomato plant…

Assessing behavioural problems and assets in children and adolescents

1990

Abstract The main purpose of this brief report is to introduce a wide range battery of instruments for the psychological assessment of children and adolescents, which was developed in Spain and coordinated by the last author. The battery includes a General Diagnostic Report (anamnesis and general way of life), two Behaviour Problem Scales (one for school and one for non-school settings), a Hyperactivity Scale, the ‘Battery of Socialization’, the I-6 (Junior) Questionnaire, the EPQ-J, a Questionnaire for the Assessment of Self-Concept, the Antisocial Behaviour Scale, a Locus of Control Scale, an Irrational Beliefs Inventory, an Assertiveness Scale, a Fear Inventory, an Anxiety Scale, a Depre…