Search results for "LONG"
showing 10 items of 3969 documents
Teacher stress and coping over an autumn term in Finland
1995
Abstract Psychological stress, coping process and the relationships between stress and coping were examined among 66 teachers representing comprehensive and upper secondary schools in Finland. The research design was longitudinal. Each person was studied four times during the autumn term of 1991 using questionnaires, which were focused on teachers' stress feelings, ways of coping and social relations to colleagues and pupils during Mondays to Thursdays and Friday morning lessons. The results showed a clear accumulation of stress during the autumn term. Four different teacher groups emerged according to the type of stress reported: (1) teachers who were only moderately stressed, (2) those wh…
Human Development from Middle Childhood to Middle Adulthood
2017
This seminal work focuses on human development from middle childhood to middle adulthood, through analysis of the research findings of the groundbreaking Jyvaskyla Longitudinal Study of Personality and Social Development (JYLS). The JYLS project, which began in 1968, has generated extensive publications over many years but this is the first comprehensive summary that presents the conceptual framework, the research design and methodology, and the findings. The study looks at the development over time of issues related to personality, identity, health, anti-social behavior, and well-being and is unparalleled in its duration, intensity, comprehensiveness and psychological richness. The thoroug…
Recidivism risk reduction assessment in batterer intervention programs: A keyindicator for program efficacy evaluation
2014
AbstractThe evidence available on the efficacy of batterer intervention programs is still limited. The aim of the present study is twofold: (1) to analyze change in a set of intervention targets and their association with reconviction in a batterer intervention program implemented in Spain, and (2) to analyze pre-treatment participants’ characteristics linked with an increased likelihood of change. The research design was a prospective longitudinal study with measures obtained in two points in time (pre-treatment and post-treatment). Self-report measures, trained program staff assessment, and reconviction official records were used. Participants consisted of 212 offenders participating in a…
Impact of prognostic factors on long-term outcomes in metastatic breast cancer (MBC) patients (pts) receiving bevacizumab (B) plus paclitaxel as firs…
2014
e12007 Background: B combined with chemotherapy (CT) significantly improves progression-free survival (PFS) and response rate (RR) vs CT alone in the first-line treatment of HER2-negative MBC. In a...
Intermittent Low-Dose IFN Gamma Treatment for Metastatic Renal Cell Carcinoma: Analysis of Factors Predicting Clinical Response and Long-Term Survival
1995
Background: Objective tumor remissions are induced by a variety of immunomodulating agents in a minority of patients suffering from metastasizing renal cell carcinoma. The results of different clinical studies, however, varied greatly for each of these treatment modalities. In order to elucidate potential causes for this variability and to further study the long-term results of intermittent low-dose IFN gamma therapy in patients with advanced renal cell cancer (RCC) we retrospectively analyzed factors predicting clinical response and long-term survival of 121 patients. Material and Methods: We retrospectively analyzed the clinical results of 5 phase II studies treating 121 patients with int…
A real-world economic analysis of biologic therapies for moderate-to-severe plaque psoriasis in Italy: results of the CANOVA observational longitudin…
2021
AbstractBackgroundPsoriasis is a chronic immune-mediated inflammatory skin disease which can also involve joints. It is often associated with burdensome comorbidities which negatively impact prognosis and quality of life (QoL). Biologic agents have been shown to be effective in controlling disease progression, but their use is associated with higher costs compared with traditional systemic treatments. The economic analysis of the CANOVA (EffeCtiveness of biologic treAtmeNts for plaque psOriasis in Italy: an obserVAtional longitudinal study of real-life clinical practice) study aims to assess the costs and cost-effectiveness of biologics in a real-world context in Italy.MethodsThe annualised…
Neurosteroids in the Retina
2003
Steroids may have a powerful role in neuronal degeneration. Recent research has revealed that steroids may influence the onset and progression of some retinal disorders as well as neurodegenerative diseases and, as in brain, they accumulate in the retina via a local synthesis (neurosteroids) and metabolism of blood-circulating steroid hormones. Their crucial role as neurodegenerative and neuroprotective agents has been also upheld in a retinal excitotoxic paradigm. These findings are reviewed especially from the emerging perspective that after an insult local changes in steroidogenic responses and consequent neurosteroid availability might turn out to be offensive or defensive cellular adap…
Dynamics, alterations, and consequences of minimally invasive intraocular pressure elevation in rats.
2014
PURPOSE: An important, yet not exclusive, aspect of primary open angle glaucoma is elevated intraocular pressure (IOP) profiles within fluctuations and pressure peaks. The study aimed at establishing minimally invasive methods for recurrent IOP elevation in rats to investigate the impact of IOP dynamics and pathomorphologic retinal alterations during and after IOP elevation. METHODS: Intraocular pressure was elevated unilaterally in Long Evans rats to a level of ≈35 mm Hg for 1 hour in a total of 30 manipulations within 6 weeks, by using two methods: (1) suction-cup oculopression and (2) loop-adjusted oculopression. Retinal thickness (RT) was measured via optical coherence tomography (OCT),…
Long Term Results of Bladder Exstrophy
1999
After primary bladder closure or urinary diversion, other factors apart from the reconstruction gain importance for individuals with the exstrophy-epispadias complex: social integration and, after reaching puberty, sexuality and fertility.