Search results for "LPE"
showing 10 items of 493 documents
T-T cell interactions during in vitro cytotoxic T lymphocyte responses. III. Antigen-specific T helper cells release nonspecific mediator(s) able to …
1980
T helper cell induction and the specificity of T cell-mediated help as generated during alloreactive and H-2-restricted, virus- or hapten-specific cytotoxic T lymphocyte (CTL) responses have been compared. With the use of a double-chamber culture system, it was possible to dissect and separately analyze the induction phase of T helper cells from the T helper cell effector function. The data obtained revealed that during alloreactive as well as H-2-restricted T cell responses, antigen-specific T helper cells are induced. Upon specific restimulation of T helper cells, helper cell function is mediated across a cell-impermeable membrane via soluble products in an apparently nonspecific and nonr…
H-2(d) mice born to and reared by HBeAg-transgenic mothers do not develop T cell tolerance toward the hepatitis B virus core gene products.
2000
The function of the secretory core gene product (HBeAg) of the human hepatitis B virus (HBV) is unknown. It has been proposed that this protein may be passed from the mother to her offspring at the perinatal stage where it might induce immune tolerance. In a previous study we have shown that the murine placenta presents an efficient barrier for the HBe protein and that H-2(b) mice born to HBeAg-positive transgenic mothers do not develop tolerance of specific cytotoxic T cells. In the present work we demonstrate that transgenic mice expressing high serum levels of HBeAg secrete only small amounts of this protein into their milk and excrete minute amounts of the viral gene product in their ur…
s-wave charmed baryon resonances from a coupled-channel approach with heavy quark symmetry
2009
We study charmed baryon resonances which are generated dynamically within a unitary meson-baryon coupled channel model that treats the heavy pseudoscalar and vector mesons on equal footing as required by heavy-quark symmetry. It is an extension of recent SU(4) models with t-channel vector meson exchanges to a SU(8) spin-flavor scheme, but differs considerably from the SU(4) approach in how the strong breaking of the flavor symmetry is implemented. Some of our dynamically generated states can be readily assigned to recently observed baryon resonances, while others do not have a straightforward identification and require the compilation of more data as well as an extension of the model to d-w…
Properties of D and D-* mesons in the nuclear medium
2009
We study the properties of D and D-* mesons in nuclear matter within a simultaneous self-consistent coupled-channel unitary approach that implements heavy-quark symmetry. The in-medium solution accounts for Pauli blocking effects and for the D and D-* self-energies in a self-consistent manner. We pay special attention to renormalization of the intermediate propagators in the medium beyond the usual cutoff scheme. We analyze the behavior in the nuclear medium of the rich spectrum of dynamically generated baryonic resonances in the C=1 and S=0 sector and their influence on the self-energy and, hence, the spectral function of D and D-* mesons. The D meson quasiparticle peak mixes with Sigma(c)…
Latvijas Universitātes Bibliotēkas jaunumi, 2015
2015
Mikroservisu aplikācijas programmatūras saskarnes dizains un labās prakses pirmās puses klientiem
2020
Maģistra darba mērķis ir piedāvāt padziļinātu mioropakalpju arhitektūras izpētu. Darbs sniedz ieskatu pašreizējā sistēmu arhitektūras jomā un pamato motivāciju mikropakalpju lietošanā. Mikropakalpju arhitektūra tiek salīdzināta ar alternatīviem risinājumiem, un sniedz detalizētu mikropakaljpu arhitektūras analīzi, izpēta tās trūkumus un ieguvumus no tās lietošanas. Tiek piedāvātas situācijas, kurās lietoto šo arhitektūras stilu kā arī tiek piedāvāti lietošanas gadījumi, rīki un risinājumi dažādu izaicinājumu risināšanai. Balstoties uz aplūkotajiem tēmām, dažādiem rīkiem, ietvariem un lietojumprogrammatūrām, tiek piedāvāts lēmumu ietvars jebkuras sistēmas izstrādei, izmantojot mikropakalpju …
Los efectos perversos de la información
1983
Sociālpedagoģiskā darbība Dienas centra audzēkņu saskarsmes prasmju veicināšanā
2021
Martas Škapares diplomdarbs “Sociālpedagoģiskā darbība Dienas centra audzēkņu saskarsmes prasmju veicināšanā” izstrādāts ar mērķi raksturot saskarsmes prasmes, to būtību bērnu un pusaudžu vecumā, kā arī izstrādāt un aprobēt sociālpedagoģiskās darbības programmu Dienas centra audzēkņu saskarsmes prasmju veicināšanā. Teorētiskajā daļā raksturots saskarsmes un saskarsmes prasmju jēdziens, saskarsmes aspekti bērnu un pusaudžu vecumā, Dienas centra darbība un tā iespējas saskarsmes prasmju veicināšanā. Praktiskajā daļā raksturots pētījums par Dienas centra audzēkņu saskarsmes prasmēm. Tika izstrādāta sociālpedagoģiskās darbības programma Dienas centra audzēkņu saskarsmes prasmju veicināšanai. Ve…
Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis
2010
Autoreactive CD4+ T lymphocytes play a vital role in the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Since the discovery of T helper 17 cells, there is an ongoing debate whether T helper 1, T helper 17 or both subtypes of T lymphocytes are important for the initiation of autoimmune neuroinflammation. We examined peripheral blood CD4+ cells from patients with active and stable relapsing-remitting multiple sclerosis, and used mice with conditional deletion or over-expression of the transforming growth factor-beta inhibitor Smad7, to delineate the role of Smad7 in T cell differentiation and autoimmune neuroinflammation. We found that Smad…
Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1- but not type 2-associated lymphokine production, prevents indu…
1993
The phosphodiesterase inhibitor pentoxifylline (POX), which is known to have pharmacological effects in animal models of multiorgan failure and endotoxin-mediated shock, was tested for its immunosuppressive potential on T lymphocyte activation in vitro and in vivo. POX was found to have a profound inhibitory effect on both mitogen- and antigen-induced proliferation of CD4+ T cells in vitro. This inhibitory activity of the drug could be reproduced by treating T lymphocytes with cAMP analogues during stimulation. Responses of repeatedly in vitro stimulated cells were much more strongly inhibited by the drug and by cAMP analogues than responses of fresh resting lymphocytes. Furthermore, POX co…