Search results for "LPE"

El revés del Derecho o supuestos sociológicos de la hipótesis golpista

1979

Zvaigžņotā Debess: 2001, Vasara (172)

2001

Contents: U.Dzērvītis. Sensational Discovery in Experimental Physics ; G.Rozenfelds. Solar Eclipse in Kamishin ; Z.Alksne, A.Alksnis. Search for Exsoplanets: Success and Complications ; Z.Alksne. A Star is Growing in a Bok Globule ; A.Balklavs. Observation of an Interesting Object by Cosmic Radio Interferometer ; A.Balklavs. HALCA – Step in Space Radio Interferometry ; T.Czarnik. Physiological Adaptation to Weightlessness ; Ilgonis Vilks. Spaceflight. Period of Great Success (1961-1973) (concluded) ; Ilgonis Vilks. Spaceflight. Almost Everyday Life (1973-2000) ; V.Straupe. About Astronomy in One of the Biggest Museum of Natural Sciences ; Imants Vilks. Contemporary Science on Eternal Life ;…

Covariant trace formalism for heavy mesons-wave top-wave transitions

1993

Heavy meson,s- top-wave, weakb→c transitions are studied in the context of the heavy quark effective theory using covariant meson wave functions. We use the trace formalism to evaluate the weak transitions. As expected from heavy quark symmetry, the eight transitions betweens- andp-wave states are described in terms of only two universal form factors which are given in terms of explicit wave function overlap integrals. We present our results in terms of both invariant and helicity amplitudes. Using our helicity amplitude expressions we discuss rate formulae, helicity structure functions and joint angular decay distributions in the decays $$\bar B \to D^{**} ( \to (D,D^* ) + \pi ) + W^ - ( \…

Amazing IL-9: revealing a new function for an “old” cytokine

2012

Th9 cells are a subset of CD4+ Th cells that produce the pleiotropic cytokine IL-9. IL-9/Th9 can function as both positive and negative regulators of immune response, but the role of IL-9/Th9 in tumor immunity is unknown. We examined the role of IL-9/Th9 in a model of pulmonary melanoma in mice. Lack of IL-9 enhanced tumor growth, while tumor-specific Th9 cell treatment promoted stronger antitumor responses in both prophylactic and therapeutic models. Th9 cells also elicited strong host antitumor CD8+ CTL responses by promoting Ccl20/Ccr6-dependent recruitment of DCs to the tumor tissues. Subsequent tumor antigen delivery to the draining LN resulted in CD8+ T cell priming. In agreement with…

Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B-restoration by exogenous interleuki…

2002

SUMMARYInsufficient stimulatory capacities of autologous dendritic cells (DC) may contribute in part to impaired T cell stimulation and therefore viral persistence in patients with chronic hepatitis B virus (HBV) infection. In order to characterize the antigen presenting functions of DC from chronic HBV carriers and controls antigen specific T cell responses were analysed. CD34+ peripheral blood progenitor cells were differentiated to immature DC in the presence of GM-CSF, IL-6/IL-6R fusion protein and stem cell factor. Proliferative CD4+ T cell responses and specific cytokine release were analysed in co-cultures of DC pulsed with HBV surface and core antigens or tetanus toxoid and autologo…

Specific Regulation of T Helper Cell 1–mediated Murine Colitis by CEACAM1

2004

Carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) is a cell surface molecule that has been proposed to negatively regulate T cell function. We have shown that CEACAM1 is associated with specific regulation of T helper cell (Th)1 pathways, T-bet–mediated Th1 cytokine signaling, and Th1-mediated immunopathology in vivo. Mice treated with anti–mouse CEACAM1-specific monoclonal antibody (mAb) CC1 during the effector phase exhibited a reduced severity of trinitrobenzene sulfonic acid colitis in association with decreased interferon (IFN)-γ production. Although oxazolone colitis has been reported as Th2 mediated, mice treated with the CC1 mAb or a CEACAM1-Fc chimeric protein…

Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation

2009

Abstract The development of inflammatory diseases implies inactivation of regulatory T (Treg) cells through mechanisms that still are largely unknown. Here we showed that mast cells (MCs), an early source of inflammatory mediators, are able to counteract Treg inhibition over effector T cells. To gain insight into the molecules involved in their interplay, we set up an in vitro system in which all 3 cellular components were put in contact. Reversal of Treg suppression required T cell–derived interleukin-6 (IL-6) and the OX40/OX40L axis. In the presence of activated MCs, concomitant abundance of IL-6 and paucity of Th1/Th2 cytokines skewed Tregs and effector T cells into IL-17–producing T cel…

Il d.leg. 231/01 preso sul serio: la Cassazione scrive l'ultimo capitolo della saga Impregilo

2022

Chiudendo una vicenda giudiziaria ormai ventennale, la Corte di Cassazione fornisce importanti indicazioni all'estensione applicativa del d.lgs. 231/2001, soffermandosi, in particolare sui meccanismi di imputazione della responsabilità agli enti, nonché sulla estensione dei poteri del'Organismo di vigilanza.

Ecological Analysis of the Helminth Community of Microtus lusitanicus (Gerbe, 1879) (Rodentia) in Asturias (NW Spain)

2021

Simple Summary The Lusitanian pine vole is an endemic rodent of the Iberian Peninsula, which has a burrowing behaviour and prefers to live underground. It feeds on bark and roots causing severe damage to trees. In Asturias (NW Spain), this species is considered a pest causing economic losses in apple orchards, damaging the tree, and sometimes even causing its death. With the aim to shed light on the helminth community of this rodent pest species and to elucidate which intrinsic and extrinsic factors affect its helminth species, a faunistic-ecological study was carried out. For this purpose, our own collection of 710 voles from several orchards of various locations in Asturias was used. The …

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

2008

After activation, CD4(+) helper T (Th) cells differentiate into distinct effector subsets. Although chemokine (C-X-C motif) receptor 5-expressing T follicular helper (Tfh) cells are important in humoral immunity, their developmental regulation is unclear. Here we show that Tfh cells had a distinct gene expression profile and developed in vivo independently of the Th1 or Th2 cell lineages. Tfh cell generation was regulated by ICOS ligand (ICOSL) expressed on B cells and was dependent on interleukin-21 (IL-21), IL-6, and signal transducer and activator of transcription 3 (STAT3). However, unlike Th17 cells, differentiation of Tfh cells did not require transforming growth factor beta (TGF-beta…