Search results for "LR"
showing 10 items of 764 documents
Precision wormlike nanoadjuvant governs potency of vaccination
2021
It remains unclear how the precise length of one-dimensional nanovehicles influences the characters of vaccination. Here, a unimolecular nanovehicle with tailored size and aspect ratio (AR) is applied to deliver CpG oligodeoxynucleotide, a Toll-like receptor (TLR) 9 agonist, as an adjuvant of recombinant hepatitis B virus surface antigen (rHBsAg), for treating chronic hepatitis B (CHB). Cationic nanovehicles with fixed width (ca. 45 nm) but varied length (46 nm-180 nm), AR from 1 to 4, are prepared through controlled polymerization and are loaded with CpG by electrostatic interaction. We reveal that the nanoadjuvant with AR = 2 shows the highest retention in proximal lymph nodes. Importantl…
Imaging-guided interventions modulating portal venous flow: Evidence and controversies
2021
Portal hypertension is defined by an increase in the portosystemic venous gradient. In most cases, increased resistance to portal blood flow is the initial cause of elevated portal pressure. More than 90% of cases of portal hypertension are estimated to be due to advanced chronic liver disease or cirrhosis. Transjugular intrahepatic portosystemic shunts, a non-pharmacological treatment for portal hypertension, involve the placement of a stent between the portal vein and the hepatic vein or inferior vena cava which helps bypass hepatic resistance. Portal hypertension may also be a result of extrahepatic portal vein thrombosis or compression. In these cases, percutaneous portal vein recanalis…
Stazioni e città - Trasporti e cultura n.38
2014
This monograph section of “Trasporti & Cultura” examines the relationship of new high-speed railroad stations to their cities. The objective is to investigate the depth and meaning of the transformations being wrought by the new stations, in a comparative international scenario. Articles on Japan and China are followed by European case studies. The academic premise that looked to railway stations and tracks as a tool to regenerate blighted urban and industrial areas is clearly reasserted. Links can be established between urban transformation, new rail technology and the siting of the stations. Reframed by the new challenges of sustainable actions, energy transition, shrinking economies, the…
Validation of Neutrophil-to-lymphocyte Ratio in a Multi-institutional Cohort of Patients With T1G3 Non–muscle-invasive Bladder Cancer
2018
The aim of this multicenter study was to investigate the prognostic role of neutrophil-to-lymphocyte ratio (NLR) and to validate the NLR cutoff of 3 in a large multi-institutional cohort of patients with primary T1 HG/G3 non-muscle-invasive bladder cancer (NMIBC).
Deep and Meaningful E-Learning with Social Virtual Reality Environments in Higher Education: A Systematic Literature Review
2021
Deep and meaningful learning (DML) in distant education should be an essential outcome of quality education. In this literature review, we focus on e-learning effectiveness along with the factors and conditions leading to DML when using social virtual reality environments (SVREs) in distance mode higher education (HE). Hence, a systematic literature review was conducted summarizing the findings from thirty-three empirical studies in HE between 2004 (appearance of VR) and 2019 (before coronavirus appearance). We searched for the cognitive, social, and affective aspects of DML in a research framework and studied their weight in SVREs. The findings suggest that the use of SVREs can provide aut…
Traducción, cultura y política en el mundo hispánico del siglo XVIII: reescribir las Lettres d'une péruvienne de Françoise de Graffigny
2014
Este artículo narra la historia de cómo se reescribió en la España peninsular una obra fundamental de la Ilustración francesa, las Lettres d’une péruvienne (1747) de Françoise de Graffigny, en un proceso tejido de conexiones personales y culturales –amistosas, clientelares, de afinidad o rivalidad intelectual y literaria– entre las dos orillas del mundo hispánico. Se pretende enriquecer el mero análisis textual de la traducción castellana firmada por María Rosario Romero en 1792, reconstruyendo el perfil biográfico de su traductora y el contexto político e intelectual en el que fue gestada y se insertó. De ese modo, emerge una trama de relaciones en las que se destacan ciertas figuras (M. R…
Railroad integration and uneven development on the European periphery, 1870-1910
2021
This study explores the relationship between railroad integration and regional development on the European periphery between 1870 and 1910, based on a regional dataset including 291 spatial units. Railroad integration is proxied by railroad density, while per capita GDP is used as an indicator of economic development. The period under study is of particular relevance as it has been associated with the second wave of railroad construction in Europe and also coincides with the industrialization of most of the continent. Overall, we found that railroads had a significant and positive impact on the growth of per capita GDP across Europe. The magnitude of this relationship appears to be relative…
Enfermar lejos de casa : la atención médica y veterinaria en los hostales de la Corona de Aragón durante la Baja Edad Media
2013
During the late Middle Ages the mobility of people was intense, for various reasons. Frequently, people stayed in hostels, which were abundant in all cities and in the countryside and where they could rest, eat and receive medical care for themselves and their horses. These hostels were favourable environments to the intervention of barbers and surgeons, because many fights resulting in injuries took place there.Durante la baja Edad Media la movilidad de las personas fue muy intensa, por razones diversas. Frecuentemente la gente se alojaba en hostales, abundantes en todas las ciudades y también en el mundo rural, donde podían descansar, alimentarse y recibir atención médica para ellos y par…
La iconografía en la era digital: hacia una heurística para el estudio del contenido de las imágenes medievales
2014
Este artículo invita a reflexionar sobre la validez de la iconografía como método para describir los temas representados en las obras artísticas medievales. En esta ocasión, se ha puesto un mayor énfasis en investigar sus implicaciones epistemológicas y los sesgos que resultan del proceso de transformar las imágenes en palabras. El objetivo principal es tratar de que aflore la llamada 'brecha semántica', una especie de barrera que impide representar verbalmente un medio no léxico, como es el visual, de manera satisfactoria y sin mermas. Tras un sucinto recorrido por el pensamiento griego, con un especial interés por la écfrasis, se sugiere que el aparente equilibrio entre las capacidades se…
Les fonts clàssiques de Curial e Güelfa
2018
Resum: Curial e Güelfa (Milà-Nàpols, ca. 1445-1448), novel·la cavalleresca escrita en català i atribuïble al gran camarlenc del Nàpols d’Alfons el Magnànim, Enyego d’Àvalos, conté una suggerent càrrega culturalista (mites ovidians tergiversats satíricament; teofanies i decorats neoplatònics; remissions explícites i/o implícites Cèsar, Macrobi, Plató, Apuleu...), que no resulta en absolut supèrflua i prescindible, com argumentà algun crític del segle passat. Al contrari: la manera d’evocar-hi els clàssics i de re-presentar-los no s’explica sense considerar els contactes de l’hipotètic escriptor amb l’humanisme llombard i napolità. D’altra banda, el repertori de clàssics greco-llatins documen…