Search results for "LR"

Clerodane diterpenoids from Salvia splendens.

2006

Four new clerodane diterpenoids, salvisplendins A-D (1-4), have been isolated from an acetone extract of the flowers of SalVia splendens, together with an artifact (5), arising from salvisplendin D (4) by addition of diazomethane, and the already known clerodane olearin (6). The structures of the new compounds (1-5) were established mainly by 1D and 2D NMR spectroscopic studies and, in the case of salvisplendin A (1), by chemical correlation with splenolide B (7). Complete 1H and 13C NMR assignments for olearin (6), not published hitherto, are also reported.

Inclusion complexes of Cethyl-2-methylresorcinarene and pyridine N-oxides: breaking the C–I⋯−O–N+ halogen bond by host–guest complexation

2016

C ethyl-2-Methylresorcinarene forms host–guest complexes with aromatic N-oxides through multiple intra- and intermolecular hydrogen bonds and C–H⋯π interactions. The host shows conformational flexibility to accommodate 3-methylpyridine N-oxide, while retaining a crown conformation for 2-methyl- and 4-methoxypyridine N-oxides highlighting the substituent effect of the guest. N-Methylmorpholine N-oxide, a 6-membered ring aliphatic N-oxide with a methyl at the N-oxide nitrogen, is bound by the equatorial −N–CH3 group located deep in the cavity. 2-Iodopyridine N-oxide is the only guest that manifests intermolecular N–O⋯I–C halogen bond interactions, which are broken down by the host resulting i…

Gülru Necipoğlu, Alina Alexandra Payne (eds.), Histories of ornament: from global to local (Princeton, Oxford, Princeton University Press, 2016)

2017

Il contributo è una segnalazione bibliografica del volume dal titolo "Histories of Ornament: From Global to Local", edito nel 2016 dalla Princeton University Press e curato da Gülru Necipoğlu e Alina Alexandra Payne. Il libro racconta l’ornamento e il suo “mondo” individuandone i tanti volti attraverso i media artistici e ripercorrendone le molte storie, teorie e storiografie generate e sviluppate a livello locale e globale, dal Medioevo all’età contemporanea.

Modelling strategic alliances in the wide-body long range aircraft market

2007

Abstract The wide-body long-range aircrafts market is characterized by increasing rivalry between Airbus and Boeing. One of the factors that drive their strategic behaviour is technological. We propose a technology indicator to identify conditions under which the aircraft companies have incentives to join a coalition. For this, we provide measurement of the side-payments necessary to sign a strategic alliance aimed at reducing technological barriers in the market. The results suggest that the existence of side-payments guarantees the stability of a strategic alliance if the gap in the technological level between the firms is high, or competition is through prices. For monopoly, a strategic …

Innate Sensing by Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

2018

MyD88, an adaptor molecule downstream of innate pathways, plays a significant tumor-promoting role in sporadic intestinal carcinogenesis, which is dependent on its function in the stroma. Here, we show that deletion of MyD88 in intestinal mesenchymal cells (IMCs) significantly reduces Apc-mediated intestinal tumorigenesis. This phenotype is associated with decreased epithelial cell proliferation, altered inflammatory and tumorigenic immune cell infiltration, and modified gene expression similar to complete MyD88 knockout mice. Genetic deletion of TLR4, but not IL1R, in IMCs led to altered molecular profiles and reduction of intestinal tumors similar to the MyD88 deficiency. Ex vivo analysis…

Ģenētisko faktoru asociācija ar Helicobacter pylori seroloģisko prevalenci Latvijas populācijā

2015

Baktērija Helicobacter pylori (HP) izraisa hronisku gastrītu, peptisko čūlu, kuņģa adenokarcinomu, MALT limfomu, un tās radītā infekcija ir visplašāk izplatītā cilvēku infekcija. Populācijas pētījumā atklāts, ka HP prevalence Latvijā ir gandrīz 80%, kas ir augsta. Pamatojoties uz Nīderlandes GWAS pētījumu rezultātiem, tika izvēlēti 5 gēni un to polimorfismi- PCLO (rs147900026), TLR10 (rs12233670), FCGR3A (rs147174426), TLE4 (rs138776142), ADRA1D (rs6107461)- lai noskaidrotu, vai šie polimorfismi asociējas ar HP seroprevalenci un kuņģa gļotādas atrofiju Latvijas populācijā. Rezultāti: PCLO gēna rs147900026 G alēle samazina HP infekcijas risku, FCGR3A gēna rs147174426 T alēle tiek būtiski aso…

Candida albicans: to be or not to be recognized by TLR4? Response to “Both TLR2 and TLR4 are involved in the recognition of Candida albicans” by M.G.…

2006

Role of TLR Polymorphisms in Immunosenescence

2009

Innate immunity provides a first line of host defense against infection through microbial recognition and killing while simultaneously activating a clonotypic immune response. Toll-like receptors (TLRs) are principal mediators of rapid microbial recognition and function mainly by detection of pathogen-associated molecular patterns (PAMPs) that do not exist in the host. The different members of TLRs recognize several PAMPs, such as peptidoglycan for TLR2, lipopolysaccharide (LPS) for TLR4, flagellin for TLR5, and CpGDNA-repeats for TLR9. Several endogenous ligands of various TLRs have been also identified in the host. In this chapter, we describe the involvement of TLR-4 polymorphisms in imm…

Tacitus on Titus? Visit to the Temple of Venus at Paphos

2020

This article deals with Titus? visit to the temple of Venus at Paphos in the second book of Tacitus? Historiae. I argue that apart from its other literary intentions already mentioned by scholars, this digression implicitly connects Titus not only with Aeneas but also with Julius Caesar. Titus? affair with Berenice that recalls Caesar?s affair with Cleopatra, Tacitus? allusions to Lucan?s De Bello Civili where Caesar?s visit to the tomb of Alexander the Great is described, the ?????Motiv and fortuna?s favour that characterise both Roman generals, all contribute to connect Titus with Caesar and allow the reader to view a parallel between the Flavian and the Julio-Claudian dynasty. Furthermor…

Cytokine Polymorphism in Takotsubo Cardiomyopathy

2014

IMIN11. Cytokine Polymorphism in Takotsubo Cardiomyopathy P. Di Gangi1, L. Scola1, S. Giambanco1, M. Bova1, G. Santini1, L. Vaccarino1, C. R. Balistreri1, D. Lio1, P. Assennato1, S. Novo1, G. Novo1 1University of Palermo, Palermo, Italy Background: Takotsubo (TT) cardiomyopathy is characterised by an acute left ventricular dysfunction triggered by emotional or physical stresses. Clinically, the syndrome is characterised by acute symptoms mimicking acute infarction without relevant electrocardiographic and biochemical markers of myocardial damage changes. Stressful events inducing an excess catecholamine release and myocardial β-adrenergic receptors (β-AR) seem to play a major role in TT. Ac…