Search results for "LR"
showing 10 items of 764 documents
Role of hematopoietic stem and progenitor cells in training immunity against infection
2022
During an infection, haematopoiesis is altered to increase the output of mature myeloid cells to fight off the pathogen. It has been demonstrated that the detection of pattern recognition receptor agonists by hematopoietic stem and progenitor cells (HSPCs) induces their differentiation towards mature myeloid cells with modified phenotypes. In the present PhD thesis, we show that an in vitro transient exposure of HSPCs to live Candida albicans cells is sufficient to induce a trained phenotype of the macrophages they produce in a dectin-1- and TLR2-dependent manner. Additionally, we use an HSPC transplantation mouse model to demonstrate that the direct interaction of β-glucans and their recep…
A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia
2016
Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN ha…
An Automatic Method for Assessing Spiking of Tibial Tubercles Associated with Knee Osteoarthritis
2022
Efficient and scalable early diagnostic methods for knee osteoarthritis are desired due to the disease’s prevalence. The current automatic methods for detecting osteoarthritis using plain radiographs struggle to identify the subjects with early-stage disease. Tibial spiking has been hypothesized as a feature of early knee osteoarthritis. Previous research has demonstrated an association between knee osteoarthritis and tibial spiking, but the connection to the early-stage disease has not been investigated. We study tibial spiking as a feature of early knee osteoarthritis. Additionally, we develop a deep learning based model for detecting tibial spiking from plain radiographs. We collected an…
Physical loading and later lower-limb function and findings : a study among male former elite athletes
2000
Senioru viedtālruņu lietošanas paradumi un motivācija Latvijā
2019
Mūsdienās viedtālruņi tiek lietoti plašā mērogā un sevī ietver gan komunikācijas, gan izklaides funkcijas. Līdz ar viedtālruņu atšķirīgo lietošanu, dažādās vecuma grupās, pastriprunās digitālās plaisas esamība, kas visspilgtāk jūtama senioru vidū, salīdzinot tos ar jaunāka gada gājuma cilvēkiem. Bakalaura darba „Senioru viedtālruņu lietošanas paradumi un motivācija Latvijā” mērķis ir izpētīt senioru viedtālruņu lietošanas paradumus un motivāciju Latvijā, par uzde-vumiem izvirzot problēmas teorētisko izpēti, empīrisko izpēti un secinājumu izdarīšanu. Tiek ietverta teorija par senioriem, paaudzēm, viedtālruņu izmantošanu un digitālo plaisu. Metodoloģija ietver sekundāro datu analī…
Effects of progressive aquatic resistance training on symptoms and quality of life in women with knee osteoarthritis: A secondary analysis.
2020
Abstract Objective: To conduct a secondary analysis to study the effects, those 4 months of aquatic resistance training have on self‐assessed symptoms and quality of life in post‐menopausal women with mild knee osteoarthritis (OA), after the intervention and after a 12‐month follow‐up period. Methods: A total of 87 post‐menopausal volunteer women, aged 60‐68 years, with mild knee OA were recruited in a randomized, controlled, 4‐month aquatic training trial (RCT) and randomly assigned to an intervention (n = 43) and a control (n = 44) group. The intervention group participated in 48 supervised aquatic resistance training sessions over 4 months while the control group maintained their usual l…
Asymmetrical muscle strength deficit, mobility limitation and aquatic resistance training in persons with knee osteoarthritis
2013
Vesiharjoittelun vaikutus polven nivelrikkoa sairastavien aerobiseen kuntoon
2015
Tutkimuksen tausta ja tarkoitus Nivelrikko on maailman yleisin nivelsairaus. Pääpaino nivelrikon hoidossa on lääkkeettömässä hoidossa. Nivelrikkopotilailla on todettu olevan alhaisempi aerobinen kunto terveisiin verrattuna. Tutkimuksen tarkoituksena oli tutkia vesiharjoittelun vaikutusta aerobiseen kuntoon polven niverikkoa sairastavilla postmenopausaalisilla naisilla. Tutkimusaineisto- ja menetelmät Tutkimusaineisto kerättiin Jyväskylässä vuosina 2012-2013. Tutkimusasetelmana oli randomisoitu kontrolloitu tutkimus. Tutkittavat (N=87) satunnaistettiin joko koe- tai kontrolliryhmään, jossa koeryhmäläiset tekivät 16 viikkoa kolme kertaa viikossa progressiivista vedessä tapahtuvaa vastusharjoi…
Exercise as stimulus for cartilage health in knee osteoarthritis
2018
Knee osteoarthritis (OA) is a leading cause of musculoskeletal pain and disability and has significant socio-economical costs globally. There is no known cure for OA. Therapeutic exercise has been shown to evoke acute positive posttreatment effects on pain and function. Even though cartilage degeneration is crucial in OA progression, there is sparse knowledge about exercise effects on osteoarthritic cartilage. The purpose of this study was to investigate the efficacy of aquatic resistance training on the estimated biochemical composition of tibiofemoral cartilage and the association between leisure time physical activity (LTPA) and tibiofemoral cartilage in postmenopausal women with mild kn…
Vesivastusharjoittelun vaikutus vaikea-asteista polven nivelrikkoa sairastavien miesten ja naisten tasapainoon
2014
Jenni Vuolahti (2014). Vesivastusharjoittelun vaikutus vaikea-asteista polvennivelrikkoa sairastavien miesten ja naisten tasapainoon. Terveystieteiden laitos, Jyväskylän yliopisto, Gerontologian ja kansanterveyden pro gradu – tutkielma, 37 s. Polven nivelrikko on ikääntyvän väestön yleinen sairaus, joka aiheuttaa merkittäviä kustannuksia yhteiskunnalle ja heikentää yksilön toimintakykyä ja elämänlaatua. Polven nivelrikon aiheuttamia toimintakyvyn ja elämänlaadun ongelmia ovat muun muassa kipu, alaraajojen lihasvoiman heikkeneminen, kävelyn vaikeutuminen sekä tasapainon heikkeneminen. Heikentynyt tasapaino rajoittaa ja hankaloittaa ikääntyvän arjesta suoriutumista ja aiheuttaa suurentuneen r…