Search results for "LRS"

showing 8 items of 8 documents

Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression.

2017

Toll-like receptors (TLRs) and nucleotide-binding oligomerisation domain (NOD)-like receptors (NLRs) are two major forms of innate immune sensors but their role in the immunopathology of stable chronic obstructive pulmonary disease (COPD) is incompletely studied. Our objective here was to investigate TLR and NLR signalling pathways in the bronchial mucosa in stable COPD.Using immunohistochemistry, the expression levels of TLR2, TLR4, TLR9, NOD1, NOD2, CD14, myeloid differentiation primary response gene 88 (MyD88), Toll-interleukin-1 receptor domain-containing adaptor protein (TIRAP), and the interleukin-1 receptor-associated kinases phospho-IRAK1 and IRAK4 were measured in the bronchial muc…

0301 basic medicineTIRAPMaleRespiratory SystemVital CapacityHAEMOPHILUS-INFLUENZAELUNG MICROBIOMEPathogenesisPulmonary Disease Chronic Obstructive0302 clinical medicineNOD2ImmunopathologyForced Expiratory VolumeNod1 Signaling Adaptor ProteinNOD1PhosphorylationCOPDSmoking11 Medical And Health SciencesMiddle AgedCPG-DNAbronchial inflammationAnti-Bacterial AgentsStreptococcus pneumoniaePseudomonas aeruginosaMOUSE LUNGFemaleLife Sciences & BiomedicineMoraxella catarrhalisSignal TransductionEXPRESSIONPulmonary and Respiratory MedicineCD14BronchiRespiratory MucosaReal-Time Polymerase Chain ReactionOBSTRUCTIVE PULMONARY-DISEASETLRs NLR bronchial inflammationNLRDENDRITIC CELL SUBSETS03 medical and health sciencesProtein DomainsmedicineHumansTLRsAgedTOLL-LIKE RECEPTORSCOPD TLR4InflammationScience & TechnologyBacteriabusiness.industrymedicine.diseaseHaemophilus influenzaeBacterial Loadrespiratory tract diseasesToll-Like Receptor 4TLR2030104 developmental biology030228 respiratory systemImmunologyINNATE IMMUNITYT-CELLSbusinessThe European respiratory journal
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Inducible Genetic Code Expansion in Eukaryotes

2020

Abstract Genetic code expansion (GCE) is a versatile tool to site‐specifically incorporate a noncanonical amino acid (ncAA) into a protein, for example, to perform fluorescent labeling inside living cells. To this end, an orthogonal aminoacyl‐tRNA‐synthetase/tRNA (RS/tRNA) pair is used to insert the ncAA in response to an amber stop codon in the protein of interest. One of the drawbacks of this system is that, in order to achieve maximum efficiency, high levels of the orthogonal tRNA are required, and this could interfere with host cell functionality. To minimize the adverse effects on the host, we have developed an inducible GCE system that enables us to switch on tRNA or RS expression whe…

Context (language use)Computational biology010402 general chemistry01 natural sciencesBiochemistryInsert (molecular biology)Amino Acyl-tRNA SynthetasesRNA TransferEscherichia coliHumansunnatural amino acidAmino AcidsMolecular BiologyT-RExchemistry.chemical_classificationTet-On010405 organic chemistryChemistryCommunicationOrganic ChemistryEukaryotaGenetic codeamber suppressionCommunications0104 chemical sciencesAmino acidMaximum efficiencyFluorescent labellingHEK293 CellsGenetic CodePylRSTransfer RNAMolecular MedicineAmber Stop CodonChemBioChem
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FPV dronu konfigurācija

2021

Bakalaura darbs “FPV Dronu Konfigurācija” izstrādāts ar mērķi izpētīt un dokumentēt FPV dro-na konfigurācijas procesu. Autors aplūkoja drona konfigurēšanās valdošos nosacījumus un šīs procedūras posmus, bakalaura darbā norādot autora ieskatā labāko drona konfigurēšanās shēmu. Autors, pievēršot uzmanību tādām programmām kā “OpenTX”, “OpenTX Configurator”, “Express LRS”, “ExpressLRS Configurator”, “Betaflight”, “Betaflight Configurator”, konstatē kā minētās programmas ir drona un radio raidītāja jeb kontrollera sastāvdaļas. Tāpat autors aplū-koja tādas drona sastāvdaļas kā ātruma kontrolleris, motors, lidojuma kontrolleris, rāmis, video raidītājs, propelleri un kamera. Tādējādi bakalaura darb…

DatorzinātneFPVOpenTXTXBetaflightExpressLRS
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Laboratory relationships between adult lifetime reproductive success and fitness surrogates in a Drosophila littoralis population

2011

The difficulties in measuring total fitness of individuals necessitate the use of fitness surrogates in ecological and evolutionary studies. These surrogates can be different components of fitness (e.g. survival or fecundity), or proxies more uncertainly related to fitness (e.g. body size or growth rate). Ideally, fitness would be measured over the lifetime of individuals; however, more convenient short-time measures are often used. Adult lifetime reproductive success (adult LRS) is closely related to the total fitness of individuals, but it is difficult to measure and rarely included in fitness estimation in experimental studies. We explored phenotypic correlations between female adult LRS…

LRSelinkiertopiirteetikääntyminenlongevityelinikäfecunditykokoagingfekunditeettilife history traits
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Laboratory relationships between adult lifetime reproductive success and fitness surrogates in a Drosophila littoralis population.

2011

The difficulties in measuring total fitness of individuals necessitate the use of fitness surrogates in ecological and evolutionary studies. These surrogates can be different components of fitness (e.g. survival or fecundity), or proxies more uncertainly related to fitness (e.g. body size or growth rate). Ideally, fitness would be measured over the lifetime of individuals; however, more convenient short-time measures are often used. Adult lifetime reproductive success (adult LRS) is closely related to the total fitness of individuals, but it is difficult to measure and rarely included in fitness estimation in experimental studies. We explored phenotypic correlations between female adult LRS…

MaleLRSAgingTime FactorsAnimal EvolutionPopulation Dynamicslcsh:MedicineEvolutionary SelectionToxicologykokoNatural Selectionlcsh:Sciencemedia_commoneducation.field_of_studyelinkiertopiirteetMultidisciplinaryEcologyReproductionMortality rateLongevityFecundityBiological EvolutionPhenotypeDrosophilaFemaleReproductionfekunditeettiResearch ArticleEvolutionary ProcessesGenotypeOffspringmedia_common.quotation_subjectfecundityLongevityPopulationFertilityBiologyForms of EvolutionAnimalsMicroevolutioneducationBiologylife history traitsEvolutionary BiologyReproductive successelinikälcsh:RagingpitkäikäisyysOrganismal EvolutionFertilityikääntyminenEvolutionary Ecologyta1181lcsh:QDemography
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Redox signaling in acute pancreatitis

2015

Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may lead to a severe systemic inflammatory response. A key event in pancreatic damage is the intracellular activation of NF-κB and zymogens, involving also calcium, cathepsins, pH disorders, autophagy, and cell death, particularly necrosis. This review focuses on the new role of redox signaling in acute pancreatitis. Oxidative stress and redox status are involved in the onset of acute pancreatitis and also in the development of the systemic inflammatory response, being glutathione depletion, xanthine oxidase activation, and thiol oxidation in proteins critical features of the disease in the pancreas. On th…

NecrosisGSH reduced glutathioneSTAT3 signal transducer and activator of transcription 3ERK extracellular signal-regulated kinasesClinical BiochemistryCCK cholecystokininTRAFs TNF receptor associated factorsReview ArticleIκB kinasePharmacologymedicine.disease_causeBiochemistrySHP small heterodimer partnerSTIM1 stromal interaction molecule 1chemistry.chemical_compoundHATs histone acetyltransferasesMedicineASK1GCL glutamate cysteine ligaseTNF-α tumor necrosis factor alphaIKK IκB kinaseNOS nitric oxide synthaseAcute inflammationHIF hypoxia inducible factorlcsh:QH301-705.5NF-κB nuclear factor kappa BDAMPs damage-associated molecular pattern moleculeslcsh:R5-920biologyGSSG oxidized glutathioneNF-kappa BNLRs nucleotide-binding oligomerization domain (NOD) like receptorsTRADD tumor necrosis factor receptor type 1-associated DEATH domain proteinTRPC3 transient receptor potential channel 3VEGF vascular endothelial growth factorGlutathioneTNFR tumor necrosis factor receptorHMGB1 high-mobility group Box 1 proteinIP3R inositol 145-trisphosphate receptor type 3VCAM-1 Vascular Cell adhesion protein 1Acute DiseaseJNK c-Jun N-terminal kinaseAcute pancreatitisTLRs toll-like receptorsmedicine.symptomlcsh:Medicine (General)Oxidation-ReductionAP-1 activator protein-1Signal TransductionmRNA messenger ribonucleic acidHMGB1ASC apoptosis-associated speck-like protein containing a carboxy-terminal CARDRNS reactive nitrogen speciesPTPs protein tyrosine phosphatasesROS reactive oxygen speciesNADH nicotinamide adenine dinucleotidepHe extracellular pHFAEE fatty acid ethyl estersAP acute pancreatitisHumansXanthine oxidaseCBP CREB-binding proteinRyR endoplasmic reticulum membrane ryanodine receptorsMDA malondialdehydeNO nitric oxideXO xanthine oxidaseASK1 apoptosis signal-regulating kinase-1business.industryOrganic ChemistryAutophagyNADPH nicotinamide adenine dinucleotide phosphateHDACs histone deacetylasesmedicine.diseaseCARS compensatory anti-inflammatory response syndromeXDH xanthine dehydrogenaseIL interleukinIκB inhibitor of kappa BAcute pancreatitisETC Electron transport chainPancreatitisMKPs MAPK phosphatasesSAP severe acute pancreatitischemistrylcsh:Biology (General)DTT dithiothreitolOxidative stressNAC N-acetyl cysteineImmunologybiology.proteinCalciumLysosomesReactive Oxygen SpeciesbusinessMAPK mitogen-activated protein kinaseOxidative stressERCP endoscopic retrograde cholangiopancreatographyRedox Biology
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Zvaigžņotā Debess: 2017, Rudens (237)

2017

Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: U.Dzērvītis. Dispute on Hubble’s Constant Value (abridged) ; E.Mūkins. Ten «Venera»’s: Devices, Journeys and Results (abridged) ; DEVELOPMENTS in SCIENCE: K.Schwartz. New Discoveries in the Orion Molecular Cloud Complex ; SPACE RESEARCH and EXPLORATION: J.Jaunbergs. Salty Emanations of Enceladus ; R.Misa. Voyager: the Longest and Farthest ; OBSERVATORIES and INSTRUMENTS: J.Kuzmanis. Dragon Looks at the Sky ; K.Salmiņš. On ILRS Technical Workshop 2017 in Riga ; CONFERENCES and MEETINGS: M.Sudārs. Trends of Space Infrastructure Development in Europe ; M.Gills. Congress of European Planetary Science 2017 in Riga ; FLASHBACK: N.Cimahoviča. On Whirl…

Oriona Molekulāro Mākoņu KomplekssLatvijas un Igaunijas praktikanti LU Astronomijas institūtāCERN zinātnes nedēļa LatvijāUrāna rotācijas virziens – lasītāja jautājumsKosmosa infrastruktūra – tendences Eiropā iespējas LatvijāLatvijas 45.atklātā skolēnu astronomijas olimpiādeZondes Voyager – intervija ar Projekta izpildītājiemLPSR ZA Radioastrofizikas observatorijai – 50ILRS lāzerlokācijas konference Rīgā:NATURAL SCIENCES::Physics::Astronomy and astrophysics [Research Subject Categories]VAĢB Latvijas nodaļai – 70Latvijas 67.matemātikas olimpiāde – uzdevumu atrisinājumiSaturna ledus pasaule Encelāds – Cassini pētījumiLatvijas 41.skolēnu zinātniskā konferenceFAST – Ķīnas 500 m stacionārais radioteleskopsEiropas Planetoloģijas kongress RīgāLatvijas Zemes mākslīgais pavadonis «Venta-1»Debess spīdekļi – 2017.gada rudensDzintaram Blūmam – 70Asteroīds (457743) Balklavs = 2009 HW20Mīkla “Kas ir šis majors?” – atminējumsSaules koronas virpuļi – ietekme uz Zemi
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Data from: Simultaneous age-dependent and age-independent sexual selection in the lekking black grouse (Lyrurus tetrix)

2016

Individuals' reproductive success is often strongly associated with their age, with typical patterns of early-life reproductive improvement and late-life senescence. These age-related patterns are due to the inherent trade-offs between life-history traits competing for a limited amount of resources available to the organisms. In males, such trade-offs are exacerbated by the resource requirements associated with the expression of costly sexual traits, leading to dynamic changes in trait expression throughout their life span. Due to the age dependency of male phenotypes, the relationship between the expression of male traits and mating success can also vary with male age. Hence, using longitu…

medicine and health careTetrao tetrixlong-term dataLRSselection differentialMedicineselection gradientlekLife sciencesARS
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