Search results for "LSA"
showing 10 items of 832 documents
National identity predicts public health support during a global pandemic
2022
Funder: Research Council of Norway through its Centres of Excellence Scheme, FAIR project No 262675
Sleep-time physiological recovery is associated with eating habits in distressed working-age Finns with overweight: secondary analysis of a randomise…
2021
Background Association of physiological recovery with nutrition has scarcely been studied. We investigated whether physiological recovery during sleep relates to eating habits, i.e., eating behaviour and diet quality. Methods Cross-sectional baseline analysis of psychologically distressed adults with overweight (N = 252) participating in a lifestyle intervention study in three Finnish cities. Recovery measures were based on sleep-time heart rate variability (HRV) measured for 3 consecutive nights. Measures derived from HRV were 1) RMSSD (Root Mean Square of the Successive Differences) indicating the parasympathetic activation of the autonomic nervous system and 2) Stress Balance (SB) indica…
Modeling the mixed-morphology supernova remnant IC 443. Origin of its complex morphology and X-ray emission
2020
The morphology and the distribution of material observed in SNRs reflect the interaction of the SN blast wave with the ambient environment, the physical processes associated with the SN explosion and the internal structure of the progenitor star. IC 443 is a MM SNR located in a quite complex environment: it interacts with a molecular cloud in the NW and SE areas and with an atomic cloud in the NE. In this work we aim at investigating the origin of the complex morphology and multi-thermal X-ray emission observed in SNR IC 443, through the study of the effect of the inhomogeneous ambient medium in shaping its observed structure, and the exploration of the main parameters characterizing the re…
Comparison of Attention Behaviour Across User Sets through Automatic Identification of Common Areas of Interest
2020
Eye tracking is used to analyze and compare user behaviour within numerous domains, but long duration eye tracking experiments across multiple users generate millions of eye gaze samples, making th ...
ω-Hetarilbutānskābes atvasinājumu iegūšana pretvēža aktivitātes noteikšanai: pieclocekļu heterocikli ar diviem heteroatomiem
2022
Ω-hetarilbutānskābes atvasinājumu iegūšana pretvēža aktivitātes noteikšanai: pieclocekļu heterocikli ar diviem heteroatomiem. Kondibo V., zinātniskais vadītājs Dr. chem. Igors Kļimenkovs. Bakalaura darbs, 32 lappuses, 34 attēli, 23 literatūras avoti, 15 pielikumi, Latviešu valodā. Bakalaura darba ietvaros ir novērtēti 4-(5-fenil-1H-3-pirazolil)butānskābe , 4-(5-fenil-3-izoksazolil)butānskābe un 4-(4-fenil-1H-2-imidazolil)butānamīds sintēzes iespējas.
Carbonyl metallo immuno assay: a new application for Fourier transform infrared spectroscopy
2000
Abstract We describe here the development of a new, non-isotopic immunological assay termed CMIA (carbonyl metallo immunoassay) that uses metal carbonyl complexes as tracers and Fourier transform infrared spectroscopy (FT-IR) as the detection method. This assay is based on the particular spectral features of these complexes, which show very strong absorption bands in the 1800–2200 cm −1 spectral range where proteins and organic molecules do not absorb. In Section 1 , the optimisation of the quantitative detection of these tracers is detailed. In Section 2 , the implementation of mono-CMIA is described, including the CMIA assays of three antiepileptic drugs (carbamazepine, phenobarbital, phe…
Production of specific antibodies and development of a non-isotopic immunoassay for carbamazepine by the carbonyl metallo-immunoassay (CMIA) method.
1995
Abstract As part of our ongoing work to extend the range of applications of the non-isotopic carbonyl metalloimmunoassay (CMIA), previously developed in our laboratory, we describe here the first CMIA study of carbamazepine. The CMIA method uses a metal carbonyl complex as a non-isotopic tracer, and in this case we chose to employ the dicobalt hexacarbonyl moiety (Co2(CO)6) attached to an alkyne. Two organometallic tracers, 3 and 7 , were synthesized, differentiated by the nature and length of the spacer arm of the Co2(CO)6 moiety. Two different coupling methods were subsequently used to synthesize the immunogens 1 and 2, the first one used a carbodiimide, while the second, employed dimethy…
Ārvalstu tiešo investīciju ietekme uz Latvijas ekonomiku
2021
Pētījuma ietvaros tiek pielietota pielāgota Granger cēloņsakarības testēšanas metodoloģija, kas pieļauj VAR modelēšanu uz nediferencētām un iespējams kointegrētām laikrindām, lai noskaidrotu vai eksistē un kādā virzienā ir novērojama cēloņsakarība starp Latvijas iedzīvotāju ienākumu līmeni, darbaspēka produktivitāti un ārvalstu tiešajām investīcijām. Analīzes rezultāti, kas tiek balstīti uz īpaša VAR sastādīšanas mehānisma un modificēta Wald testa, liecina, ka ārvalstu investīcijām Latvijā nav cēloņsakarības ne ar labklājības līmeni, ne ar darbaspēka produktivitāti. Turklāt impulsa atbildes funkcijas norāda, ka ĀTI un darbaspēka produktivitātes šoki uz ienākumu līmeni ir īstermiņa un pārejo…
Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systema…
2020
Publisher's version (útgefin grein)
Hydantoin-substituted 4,6-dichloroindole-2-carboxylic acids as ligands with high affinity for the glycine binding site of the NMDA receptor.
2002
A novel series of C-3 substituted 4,6-dichloroindole-2-carboxylic acids was synthesized to investigate the influence of different hydrogen-bond donor and acceptor groups at this specific position on the affinity to the glycine site of the NMDA receptor. These novel 3-indolylmethyl derivatives with ring-open (amines, sulfonamides, amides, ureas) and cyclic substituents (imidazolidin-2-ones, (thio)hydantoins) led to the discovery that compounds bearing a hydantoin substituent at the C-3 position of the indole nucleus are the most promising ones. In this series the hydantoins, ureas, and imidazolidin-2-ones were identified as very potent inhibitors of the binding of the glycine site specific l…