Search results for "LTD"
showing 10 items of 15 documents
Theoretical foundations and applications of the Loop-Tree Duality in Quantum Field Theories
2015
152 páginas. Tesis Doctoral del Departamento de Física Teórica, de la Universidad de Valencia y del Instituto de Física Corpuscular (IFIC).
Addictive neurons
2017
Since the reward center is considered to be the area tegmentalis ventralis of the hypothalamus, logically its neurons could mainly be responsible for addiction. However, the literature asserts that almost any neurons of CNS can respond to one or another addictive compound. Obviously not only addictive nicotine, but also alcohol, amphetamine, cannabis, cocaine, heroin and morphine may influence dopaminergic cells alone in VTA. Moreover, paradoxically some of these drugs ameliorate symptoms, counterbalance syndromes, cure diseases and improve health, not only those related to the CNS and in adults, but also almost all other organs and in children, e.g. epilepsy.
Complete 1H and 13C NMR assignments of clerodane diterpenoids of Salvia splendens.
2006
Unambiguous and complete assignments of 1H and 13C NMR chemical shifts for five clerodane diterpenes, four of them isolated from Salvia splendens (salviarin, splendidin and splenolides A and B) and one obtained by acetylation of splenolide A, are presented. The assignments are based on 2D shift-correlated [1H,1H–COSY, 1H,13C-gHSQC–1J(C,H) and 1H,13C-gHMBC-nJ(C,H) (n = 2 and 3)] and nuclear Overhauser effect (NOE) experiments. The conformation of the rings of these compounds is supported by the 3J(H,H) values and NOE results. Copyright © 2006 John Wiley & Sons, Ltd.
Rate of deleterious mutation and the distribution of its effects on fitness in vesicular stomatitis virus
1999
Despite their importance, the parameters describing the spontaneous deleterious mutation process have not been well described in many organisms. If mutations are important for the evolution of every living organism, their importance becomes critical in the case of RNA-based viruses, in which the frequency of mutation is orders of magnitude larger than in DNA-based organisms. The present work reports minimum estimates of the deleterious mutation rate, as well as the characterization of the distribution of deleterious mutational effects on the total fitness of the vesicular stomatitis virus (VSV). The estimates are based on mutation-accumulation experiments in which selection against deleteri…
Epistasis and the Adaptability of an RNA Virus
2005
Abstract We have explored the patterns of fitness recovery in the vesicular stomatitis RNA virus. We show that, in our experimental setting, reversions to the wild-type genotype were rare and fitness recovery was at least partially driven by compensatory mutations. We compared compensatory adaptation for genotypes carrying (1) mutations with varying deleterious fitness effects, (2) one or two deleterious mutations, and (3) pairs of mutations showing differences in the strength and sign of epistasis. In all cases, we found that the rate of fitness recovery and the proportion of reversions were positively affected by population size. Additionally, we observed that mutations with large fitness…
Riga devicta ab augustissimo principe Gvstavo Adolpho Svecorvm, Gothorvm, Vandalorvmqve rege, magno principe Finlandiae, duce Esthoniae, Careliaque, …
1625
Saturs:Apsveikuma dzejolis: Illustri ac generoso Domino Iacobo de la Gardie [..] Rigensis Gubernatori &c. post devictam Derpatum, plurimasque arces Livoniae, filiola divinitus orbato [39.-40.] lpp. (Grāfam Jakobam Delagardijam Zviedrijas militārajam un valsts darbiniekam, feldmaršalam (1620), Zviedru Vidzemes ģenerālgubernatoram (1621–1628)). Izdevums pieejams arī: https://digital.slub-dresden.de/werkansicht/dlf/20246/
Pasaules spogulis
1599
Teoloģiski, filozofiski ētisks un vēsturisks traktāts, viens no apjomīgākajiem N. Molllīna iespieddarbiem. Izdots arī latīņu valodā (1588, 1599). Vācu valodas izdevums dāvāts Livonijas karavadonim dažādu valstu karadienestā Georgam Fārensbaham (1551-1602), Cēsu pirmajam vaivadam no 1598. gada līdz 1602. gadam, kad krita karā pret zviedriem aplencot Vīlandes pili. Grāmatas titullapu ietver ornamentāla aproce ar dažādām fantastiskām būtnēm, grifiem, jūras vāravām utml. Ievadā publicēta Dāvida Hilhena vēstule Georgam Cīgleram. Tad seko Dāniela Hermaņa sacerētais Georga Fārensbaha dzīves apraksts. Šis G. Cīglera darbs ir vienīgais Mollīna iespieddarbs, kas guvis plašāku ievērību ārpus Livonijas…
Dopamine restores limbic memory loss, dendritic spine structure, and NMDAR-dependent LTD in the nucleus accumbens of alcohol-withdrawn rats
2018
Alcohol abuse leads to aberrant forms of emotionally salient memory, i.e., limbic memory, that promote escalated alcohol consumption and relapse. Accordingly, activity-dependent structural abnormalities are likely to contribute to synaptic dysfunctions that occur from suddenly ceasing chronic alcohol consumption. Here we show that alcohol-dependent male rats fail to perform an emotional-learning task during abstinence but recover their functioning byl-3,4-dihydroxyphenylalanin (l-DOPA) administration during early withdrawal.l-DOPA also reverses the selective loss of dendritic “long thin” spines observed in medium spiny neurons of the nucleus accumbens (NAc) shell of alcohol-dependent rats d…
Morphological determination of the phototrophic community composition of biological soil crusts in coastal sand dunes in northern Germany
2022
This dataset comprises the microbial community composition of biological soil crusts in north-German sand dunes. For this we obtained enrichment cultures of phototrophic microorganisms, by placing fragments of biocrusts of the same Petri dishes as used for sequencing, in Petri dishes with Bold Basal (1N BBM) agarized medium (Bischoff and Bold 1963). Cultures were grown under standard laboratory conditions: with a 12-hour alteration of light and dark phases and irradiation of 25 μmol photons m-2 s-1 at a temperature 20 ± 5 ºС. Microscopic study of these raw cultures began in the third week of cultivation. Morphological examinations were performed using Olympus BX53 light microscope with Noma…
GENETIC VARIABILITY AND DRIFT LOAD IN POPULATIONS OF AN AQUATIC SNAIL
2004
Population genetic theory predicts that in small populations, random genetic drift will fix and accumulate slightly deleterious mutations, resulting in reduced reproductive output. This genetic load due to random drift (i.e., drift load) can increase the extinction risk of small populations. We studied the relationship between genetic variability (indicator of past population size) and reproductive output in eight isolated, natural populations of the hermaphroditic snail Lymnaea stagnalis. In a common laboratory environment, snails from populations with the lowest genetic variability mature slower and have lower fecundity than snails from genetically more variable populations. This result s…