Search results for "LUDI"
showing 10 items of 753 documents
Optimizing Sequential Systemic Therapies for Advanced Hepatocellular Carcinoma: A Decision Analysis
2020
Background: An optimal sequential systemic therapy for advanced hepatocellular carcinoma (HCC) has not been discovered. We developed a decision model based on available clinical trials to identify an optimal risk/benefit strategy for sequences of novel systemic agents. Methods: A Markov model was built to simulate overall survival (OS) among patients with advanced HCC. Three first-line (single-agent Sorafenib or Lenvatinib, and combination of Atezolizumab plus Bevacizumab) followed by five second-line treatments (Regorafenib, Cabozantinib, Ramucirumab, Nivolumab, Pembrolizumab) were compared in fifteen sequential strategies. The likelihood of transition between states (initial treatment, ca…
The Second APOKASC Catalog: The Empirical Approach
2018
We present a catalog of stellar properties for a large sample of 6676 evolved stars with APOGEE spectroscopic parameters and \textit{Kepler} asteroseismic data analyzed using five independent techniques. Our data includes evolutionary state, surface gravity, mean density, mass, radius, age, and the spectroscopic and asteroseismic measurements used to derive them. We employ a new empirical approach for combining asteroseismic measurements from different methods, calibrating the inferred stellar parameters, and estimating uncertainties. With high statistical significance, we find that asteroseismic parameters inferred from the different pipelines have systematic offsets that are not removed b…
Spatio-Temporal Assessment of the European Hake (Merluccius merluccius) Recruits in the Northern Iberian Peninsula
2021
14 pages, 9 figures, 3 tables.-- This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
Permeability properties of a three-cell type in vitro model of blood-brain barrier.
2005
We previously found that RBE4.B brain capillary endothelial cells (BCECs) form a layer with blood‐brain barrier (BBB) properties if co‐cultured with neurons for at least one week. As astrocytes are known to modulate BBB functions, we further set a culture system that included RBE4.B BCECs, neurons and astrocytes. In order to test formation of BBB, we measured the amount of (3)H‐sucrose able to cross the BCEC layer in this three‐cell type model of BBB. Herein we report that both neurons and astrocytes induce a decrease in the permeability of the BCEC layer to sucrose. These effects are synergic as if BCECs are cultured with both neurons and astrocytes for 5 days, permeability to sucrose decr…
Conceptualization for intended action: A dynamic model
2023
Concepts are the building blocks of higher-order cognition and consciousness. Building on Conceptual Spaces Theory (CST) and proceeding from the assumption that concepts are inherently dynamic, this paper provides historical context to and significantly elaborates the previously offered Iterative Subdivision Model (ISDM) with the goal of pushing it toward empirical testability. The paper describes how agents in continuous interaction with their environment adopt an intentional orientation, estimate the utility of the concept(s) applicable to action in the current context, engage in practical action, and adopt any new concepts that emerge: a largely pre-intellectual cycle that repeats essent…
Development and Initial Validation of the Humor Climate in Sport Scale
2021
In sport teams, humor is an essential element that influences communication processes, and plays an important role in group dynamics. Despite this, no current instrument is presented in the literature to measure humor climate in sport teams. Therefore, the current study presents the development and initial validation of the Humor Climate in Sport Scale (HCSS). The aim was to assess content, structural and concurrent validity of the developed instrument, and to examine differential item functioning (DIF) as a function of sex. Three different phases were completed in this study. The first phase involved focus groups (n= 5) that explored humor as communication in a team sport context. In phase…
Tesserae frumentariae, nummariae et ‘Spintriae’ Hispaniae. Hallazgos y nuevas perspectivas
2019
This paper aims at presenting a series of unpublished imperial tesserae, originating from various Spanish institutions and sites, although most of the pieces have been found in present-day Andalusia. These tesserae are not only of the erotic type, commonly known as ‘ (sρintriαe)’, but also bear imperial busts and ludic scenes. All these tokens can be related to the incipient municipalization of Baetica and, therefore, its direct connection to Italy. But we also know that throughout the 1st and 2nd centuries AD there were ludi in Hispania. Except for Pollentia (Majorca), the tesserae seem to originate mainly from the city of Rome ; their import to the Iberian Peninsula was carried out by leg…
Thermalization and condensation in an incoherently pumped passive optical cavity
2011
International audience; We study theoretically and numerically the condensation and the thermalization of classical optical waves in an incoherently pumped passive Kerr cavity. We show that the dynamics of the cavity exhibits a turbulent behavior that can be described by the wave turbulence theory. A mean-field kinetic equation is derived, which reveals that, in its high finesse regime, the cavity behaves essentially as a conservative Hamiltonian system. In particular, the intracavity turbulent field is shown to relax adiabatically toward a thermodynamic equilibrium state of energy equipartition. As a consequence of this effect of wave thermalization, the incoherent optical field undergoes …
Impact of the Hypoechogenicity Criteria on Thyroid Nodule Malignancy Risk Stratification Performance by Different TIRADS Systems
2021
Background: Various Thyroid Imaging and Reporting data systems (TIRADS) are used worldwide for risk stratification of thyroid nodules. Their sensitivity is high, while the specificity is suboptimal. The aim of the study was to compare several TIRADS systems and evaluate the effect of hypoechogenicity as a sign of risk of malignancy on the overall assessment of diagnostic accuracy. Methods: The prospective study includes 274 patients with 289 thyroid nodules to whom US and risk of malignancy were assessed according to four TIRADS systems—European (EU-TIRADS), Korean (K-TIRADS), TIRADS by American College of Radiology (ACR TIRADS), and modified Kwak et al. TIRADS (L-TIRADS) systems, in which …
Performance of Contrast-Enhanced Ultrasound in Thyroid Nodules: Review of Current State and Future Perspectives
2021
Simple Summary Ultrasound has been used as baseline imaging for thyroid nodules for decades; nevertheless, no single feature is sensitive or specific enough to exclude or confirm thyroid malignancy. Therefore, clinical practice and research still focus on less invasive diagnostic patterns to reduce unnecessary fine-needle aspiration biopsies or surgery. The main advantage of CEUS is the ability to assess the sequence and intensity of vascular perfusion and hemodynamics in the thyroid nodule, thus providing real-time characterization of nodule features, and considered a valuable new approach in the determination of benign vs. malignant nodules. In addition, contrast agents used in CEUS can h…