Search results for "LUDI"
showing 10 items of 753 documents
Anti-inflammatory activity in selected Antarctic benthic organisms
2014
Antarctic benthos was prospected in search for anti-inflammatory activity in polar benthic invertebrates, in two different geographical areas: deep-bottoms of the Eastern Weddell Sea and shallow-waters of the South Shetland Islands. A total of 36 benthic algae and invertebrate species were selected to perform solubility tests in order to obtain extracts that were soluble at an innocuous ethanol concentration (0.2%) for cell culture, and further test them for anti-inflammatory activity. From these, ethanol extracts of ten species from five different phyla resulted suitable to be studied in cell macrophage cultures (RAW 264.7). Cytotoxicity (MTT method) and production of inflammatory mediator…
Peat stratigraphy and changes in peat formation during the Holocene in Latvia
2015
Mires represented by raised bogs, fens, and transitional mires cover approximately 10 % of Latvia. They started to form towards the end of the last glacial period and the beginning of the Holocene under varying geological and palaeoecological conditions. The aim of the study was to evaluate how the results of peat palaeobotanical investigation can reveal changes in the conditions of peat formation and allow a subdivision to be made of the Holocene according to the scheme suggested by the INTIMATE group (Walker et al. 2012). Records from 21 mires have been evaluated to find evidence of changes in mire vegetation and peat formation, and to discover whether these records define boundaries allo…
Ietekmes funkciju teorija un gludi nošķeltā vidējā vērtība
2018
Darbā izklāstīta ietekmes funkciju teorija, to formulējumi dažādu klašu novērtējumiem, kā arī to pielietojamība citu robustu mēru iegūšanā. Teorētiskajā daļā tiek apskatīta arī mazāk zināmā gludi nošķeltā vidējā vērtība, kura literatūrā tiek piedāvāta kā alternatīva nošķeltajai vidējai vērtībai. Tāpēc darba praktiskajā daļā ar simulāciju palīdzību no dažādiem izlašu sadalījumiem tiek pētītas šī novērtējuma priekšrocības un trūkumi salīdzinājumā ar nošķelto vidējo vērtību. Papildus šis novērtējums tiek salīdzināts ar citiem robustiem novērtējumiem, piemēram, Hubera novērtējumu, gludo Hubera novērtējumu, kā arī tiek analizēti tā un citu novērtējumu rezultāti uz reāliem datu piemēriem.
The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value
2021
AbstractIron is a fundamental nutrient utilized by living cells to support several key cellular processes. Despite its paramount role to sustain cell survival, excess of labile iron availability can inflict severe cell damage via reactive oxygen species generation which, in turn, can promote neoplastic transformation. The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tensions herein present. Moreover, cigarette smoke as well as air pollution particulate can function as vehicles of iron supply, leading to an iron dysregulation condition shown to be crucial in the pathogenesis of several respiratory diseases including lung cancer. Hephaestin (HEPH) bel…
Recent improvements in in situ hybridization for the detection of HPV infections in clinical samples
2020
Objective: Human Papilloma Virus (HPV) infection is well-established as a cause of cervical cancer. Importantly, early HPV detection can decrease both the frequency and mortality of HPV-related cancers. In situ hybridization (ISH) is a widely used method for the early detection of HPV. Yet, ISH can be expensive, time-consuming and, in some cases, insufficiently sensitive to detect nucleic acid target at low copy number, which may lead to false-positive or false-negative results. To address these limitations, we recently developed a novel in situ hybridization technology based on proprietary Loop RNA probes (LRPs), which provides enhanced sensitivity, high-specificity and improved cost-effec…
Vesiclepedia:A Compendium for Extracellular Vesicles with Continuous Community Annotation
2012
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.
C1q–Ha matrix regulates the local synthesis of hyaluronan in malignant pleural mesothelioma by modulating has3 expression
2021
Increased hyaluronic acid (HA) production is often associated with cancer progression. In malignant pleural mesothelioma (MPM), HA is found at elevated levels in pleural effusions and sera of patients, and it has been widely debated whether MPM cells are able to produce HA by themselves or through the release of growth factors stimulating other cells. Another key component of the MPM microenvironment is C1q, which can act as a pro-tumorigenic factor favoring cell adhesion, migration and proliferation. The aim of the current study was to prove that MPM primary cells are able to synthesize HA and to inquire the stimulus given by C1q&ndash
Density Decline in a Mediterranean Seahorse Population: Natural Fluctuations or New Emerging Threats?
2021
Illegal wildlife trade is considered one of the most serious threats to biodiversity worldwide, along with habitat loss/degradation and overfishing of wild stocks. Seahorses are considered at high risk as these fish represent an important component of traditional Chinese medicine but are also sold as curios and ornamental fish. On a worldwide level, illegal trade is controlled by numerous laws and regulations, but it seems to continue by assuming more dynamic routes. In the Mediterranean Sea, Hippocampus guttulatus formed one of the largest populations at Mar Piccolo di Taranto in South-Eastern Italy. During the routine monitoring of this population in 2016, a dramatic density decrease was …
First-Line Treatments for Extensive-Stage Small-Cell Lung Cancer With Immune Checkpoint Inhibitors Plus Chemotherapy: A Network Meta-Analysis and Cos…
2022
BackgroundImmune checkpoint inhibitors (ICIs) plus chemotherapy were unlikely to be considered cost-effective compared with chemotherapy as the first-line treatment of patients with extensive-stage small-cell lung cancer (ES-SCLC) in China due to its high costs. However, the cost-effectiveness of the comparison between the regimens of ICIs plus chemotherapy were remained unclear yet. The aim of this study was to evaluate the efficacy and cost-effectiveness of ICIs plus chemotherapy as the first-line treatment for ES-SCLC from the perspective of the Chinese healthcare system.MethodsA network meta-analysis (NMA) was conducted to indirect compare the clinical benefits between the ICIs plus che…
The Application of CRISPR/Cas9 Technology for Cancer Immunotherapy: Current Status and Problems
2022
Cancer is one of the main causes of disease-related deaths in the world. Although cancer treatment strategies have been improved in recent years, the survival time of cancer patients is still far from satisfied. Cancer immunotherapy, such as Oncolytic virotherapy, Immune checkpoints inhibition, Chimeric antigen receptor T (CAR-T) cell therapy, Chimeric antigen receptor natural killer (CAR-NK) cell therapy and macrophages genomic modification, has emerged as an effective therapeutic strategy for different kinds of cancer. However, many patients do not respond to the cancer immunotherapy which warrants further investigation to optimize this strategy. The clustered regularly interspaced short …