Search results for "LYN"
showing 10 items of 910 documents
Investigation of buckling characteristics of cracked variable stiffness composite plates by an eXtended Ritz approach
2021
Abstract Variable Angle Tow (VAT) composite plates are characterized by in-plane variable stiffness properties, which opens to new concepts of stiffness tailoring and optimization to achieve higher structural performance for advanced lightweight structures where damage tolerance consideration are often mandatory. In this paper, a single-domain eXtended Ritz formulation is proposed to study the buckling behaviour of variable stiffness laminated cracked plates. The plate behaviour is described by the first order shear deformation theory whose generalized displacements, namely reference plane translations and rotations, are expressed via suitable admissible trial functions. These consist of a …
Semi-Supervised Remote Sensing Image Classification based on Clustering and the Mean Map Kernel
2008
This paper presents a semi-supervised classifier based on the combination of the expectation-maximization (EM) algorithm for Gaussian mixture models (GMM) and the mean map kernel. The proposed method uses the most reliable samples in terms of maximum likelihood to compute a kernel function that accurately reflects the similarity between clusters in the kernel space. The proposed method improves classification accuracy in situations where the available labeled information does not properly describe the classes in the test image.
No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Data…
2021
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mismatch repair (MMR) genes have an increased risk of developing colorectal (CRC), endometrial, ovarian, urinary tract, prostate, and other cancers, depending on which gene is malfunctioning. In Lynch syndrome, differences in cancer incidence (penetrance) according to the gene involved have led to the stratification of cancer surveillance. By contrast, any differences in penetrance determined by the type of pathogenic variant remain unknown. Objective. To determine cumulative incidences of cancer in carriers of truncating and missense or aberrant splicing pathogenic …
The central polynomials of the infinite-dimensional unitary and nonunitary Grassmann algebras
2010
For a fixed field $k$, let $k_0\langle X\rangle$ and $k_1\langle X \rangle$ denote respectively the free nonunitary associative $k$-algebra and the free unitary associative $k$-algebra on the countable set $X=\{x_1, x_2, \ldots\}.$ A polynomial $f\in k_i\langle X\rangle$ is called a central polynomial for an associative algebra $A$ if every evaluation of $f$ on $A$ lies in the center of $A.$ The set of all central polynomials of $A$ is a $T$-space of $k_i\langle X\rangle,$ i.e, a subspace closed under all endomorphisms of $k_i\langle X\rangle.$ In this paper the authors describe the T-space of central polynomials for both the unitary and the nonunitary infinite-dimensional Grassmann algebra…
Graded central polynomials for the matrix algebra of order two
2009
Let K be an infinite integral domain and $A=M_2(K)$ the algebra of $2\times 2$ matrices over $K$. The authors consider the natural $\mathbb{Z}_2$-grading of $A$ obtained by requiring that the diagonal matrices and the off-diagonal matrices are of homogeneous degree $0$ and $1$, respectively. When $K$ is a field, a basis of the graded identities of $A$ was described in [O. M. Di Vincenzo, On the graded identities of $M_{1,1}(E).$ Israel J. Math. 80 (1992), no. 3, 323-–335] in case $\mbox{char}\, K = 0$ and in [P. E. Koshlukov and S. S. de Azevedo, Graded identities for T-prime algebras over fields of positive characteristic. Israel J. Math. 128 (2002), 157-–176] when $K$ is infinite and $\mb…
Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed m…
2002
In the biosynthesis of the antiarrhythmic alkaloid ajmaline, polyneuridine aldehyde esterase (PNAE) catalyses a central reaction by transforming polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmalane skeleton. The PNAE cDNA was previously heterologously expressed in E. coli. Sequence alignments indicated that PNAE has a 43% identity to a hydroxynitrile lyase from Hevea brasiliensis, which is a member of the α/β hydrolase superfamily. The catalytic triad, which is typical for this family, is conserved. By site-directed mutagenesis, the members of the catalytic triad were identified. For further detection of the active residues, a model…
PolyAT chemical denaturation in w/o microemulsion
2004
CD and UV spectroscopies have been used to investigate the effects caused by the addition of either strong acid-or base-containing microemulsions on the behaviour of the synthetic polynucleotide polyAT entrapped in the aqueous core of a cationic quaternary water-in-oil microemulsion (μE). The titrations were performed in the presence of variable concentrations of NaCl, in the range 0.00 to 0.60 M. In both cases, the primary effect was the reversible transition from B-double helix to random coil of the guest polynucleotide. However, in the microemulsive medium, the number of moles of protons (RH) and hydroxide ions (ROH) per mole of titrable sites are independent of the salt concentration bu…
Manganese(III)-mediated oxidative carbon-carbon bond cleavage of the 1,10-phenanthroline-5,6-dione ligand
1999
[EN] A new manganese(III)-1,10-phenanthroline-5,6-dione (phendione) complex possessing a putative Mn-2(mu-O) (mu-O2CMe)(2) core has been found to undergo a Ligand-based oxidative cleavage of the C(5)-C(6) bond in weak acid aqueous MeOH under aerobic conditions at room temperature to yield 2,2'-bipyridyl-3,3'-dicarboxylate with co-reduction to the corresponding Mn-II-phendione species.
Prebiotic polypeptides and the origin of biological information.
1983
Recent data on the origin of biological information are reviewed. These data corroborate the view that polyamino acids were the first informational polymers. The source of information is seen in the chemical reactivity of amino acids, their prebiotic abundance and the prebiotic environment. Evidence is presented in favor of Matsuno's protohypercycle that may have preceded Eigen's hypercycle, but that involves a translation of information from polypeptides into that of polynucleotides.
Self-instructed condensation of amino acids and the origin of biological information
1984
In contemporary cells biological information is largely stored in nucleic acids. Therefore, a prerequisite in many theories on the origin of cellular life is the pre-existence of self-replicating polynucleotides that had to be formed by abiotic processes on the prebiotic Earth. It is usually assumed that the spontaneous synthesis of a self-replicating polynucleotide could take place readily. However, serious stereochemical obstacles exist which make such a synthesis extremely improbable. Amino acids, on the other hand, which are abundantly formed in prebiotic simulation experiments, are relatively easily polymerized to macromolecules (protoproteins) that share with modern proteins many prop…