Search results for "Label"
showing 10 items of 797 documents
A novel homologous model for noninvasive monitoring of endometriosis progression.
2017
To date, several groups have generated homologous models of endometriosis through the implantation of endometrial tissue fluorescently labeled by green fluorescent protein (GFP) or tissue from luciferase-expressing transgenic mice into recipient animals, enabling noninvasive monitoring of lesion signal. These models present an advantage over endpoint models, but some limitations persist; use of transgenic mice is laborious and expensive, and GFP presents poor tissue penetration due to the relatively short emission wavelength. For this reason, a homologous mouse model of endometriosis that allows in vivo monitoring of generated lesions over time and mimics human lesions in recipient mice wou…
Monoclonal antibodies recognizing larval- and pupal-specific cuticular proteins of Tenebrio molitor (Insecta, Coleoptera)
1993
To study the sequential expression of insect epidermal cells during metamorphosis, a library of monoclonal antibodies (MABs) was prepared against the water-soluble proteins from preecdysial pupal cuticle of Tenebrio molitor. Six selected MABs recognizing only larval and pupal cuticular proteins (CPs) in immunoblot analysis were classified into three types. Type 1 recognized a 21.5 and a 22 kDa polypeptide, type 2, a 26 kDa polypeptide, and type 3, three polypeptides of 18.5, 19.5 and 21.5 kDa. They did not immunoreact with any protein of fat bodies or haemolymph from pharate pupae, suggesting that the antigens originate from the epidermis. The stage-specificity was confirmed by electron mic…
The deubiquitinase USP11 is a versatile and conserved regulator of autophagy
2021
Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is important for the precise control of autophagy pathways. Here, we show that the deubiquitinase ubiquitin-specific protease 11 (USP11) restricts autophagy and that KO of USP11 in mammalian cells results in elevated autophagic flux. We also demonstrate that depletion of the USP11 homolog H34C03.2 in Caenorhabditis elegans triggers hyperactivation of autophagy and protects the animals against human amyloid-β peptide 42 aggregation-induced paralysis. USP11…
An eco-label for the airline industry?
2017
Air travel plays a vital role in today's life because it makes remote destinations accessible and short getaways possible. Despite its benefits, air transportation contributes heavily to climate change. Behavioral change is seen as a key driver in mitigating the environmental impacts of air travel. One way to encourage behavioral change is to use eco-labels. This study explores how an eco-label could be developed for the airline industry to function as a potential driver for behavioral change. 12 interviews with airline industry experts were conducted and thematically analyzed. Empirical results were then combined with prior research and the following five criteria essential for the develop…
The effect of an eco-label on the booking decisions of air passengers
2022
In the last few years there has been an increasing attempt to find solutions on how to mitigate the environmental impacts of air travel. Behavioral change has hereby been identified as the measure with the most significant impact. One way to encourage behavioral change is the use of eco-labels. Eco-labels have, to date, received scant attention in the aviation industry, and their effect on air travel behavior is still largely unknown. This study explores the effect of an eco-label on the booking decisions of passengers. We conduct a stated choice experiment with 553 air passengers. Our findings show that providing passengers with an eco-label leads to behavioral change, as the label makes t…
Co-expression and Functional Interaction of Silicatein with Galectin
2006
Sponges (phylum Porifera) of the class of Demospongiae are stabilized by a siliceous skeleton. It is composed of silica needles (spicules), which provide the morphogenetic scaffold of these metazoans. In the center of the spicules there is an axial filament that consists predominantly of silicatein, an enzyme that catalyzes the synthesis of biosilica. By differential display of transcripts we identified additional proteins involved in silica formation. Two genes were isolated from the marine demosponge Suberites domuncula; one codes for a galectin and the other for a fibrillar collagen. The galectin forms aggregates to which silicatein molecules bind. The extent of the silicatein-mediated s…
Data from: Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy
2019
Background. For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. Methods. The STAR Network "Depot" Study is an observational, longitudin…
Transferability to LDC of Some European standards concerning the environmental certification of products and services
2002
Goal and Scope. Western developed countries (DC) are currently involved in an important process of releasing new rules and standards devoted to the environmental certifications of urban systems, in order of accomplishing the requirements established by the international protocols (Kyoto, among them), aimed at the reduction of greenhouse gases emitted in the atmosphere and at the limitation of the environmental impact as well. Within this frame, the European Union is giving a rising importance to the so-called 'Integrated Product Policy' (IPP), that is an integrated approach of the environmental policy, aiming to an improvement of the environmental performance of products and services during…
Environmental performance of building materials: life cycle assessment of a typical Sicilian marble
2009
Background, aim, and scope: The building sector is strategically important for achieving sustainability. Therefore, the improvement of energy and environmental performances are relevant targets because precious building materials such as marble have a significant impact on the environment. The aim of this paper is an analysis of a typical Sicilian marble (Perlato di Sicilia) to evaluate its energy and environmental performance. Marble plays an important role in the economy of Italy and has a global market share of 58% in terms of exports. For the main production areas of marble, relevant environmental performance data are missing except for one region (Tuscany-Massa e Carrara province). Per…
Medicamentos utilizados en pediatría extrahospitalaria: ¿disponemos de información suficiente?
2008
Objetivo: Analizar los medicamentos que reciben los pacientes pediátricos en el ámbito extrahospitalario y la información disponible sobre los mismos. Pacientes y métodos: Estudio transversal, observacional y descriptivo realizado en una muestra de pacientes menores de 14 años atendidos en urgencias del Servicio de Pediatría del Consorcio Hospital General Universitario de Valencia entre junio 2005 y agosto 2006. Se cuantifican y clasifican los medicamentos utilizados antes de acudir a urgencias y se analiza la información sobre su uso que contiene el Vademécum Internacional Medicom y la ficha técnica. Resultados: Se recogió información sobre 462 niños con media de edad de 5,2 años (interval…