Search results for "Lability"
showing 10 items of 802 documents
In vitro digestion of two age-tailored dairy products in the aging gastrointestinal tract
2023
For older adults (> 65 years old), undernutrition is a severe health problem that can impact the quality of life, induce or aggravate the development of diseases, and reduce life expectancy. Undernutrition can be defined as an inadequate intake of dietary energy and proteins combined with a low muscle mass. Diet-induced muscle mass and strength loss in older adults may be due to insufficient protein intake. Therefore, older adults need to increase the amount of high-quality ingested proteins, particularly foods rich in leucine, to promote muscle health. However, it is still unclear if changes in protein digestibility and absorption kinetics in old age may affect the anabolic effect of high-…
Analyzing big datasets of genomic sequences: fast and scalable collection of k-mer statistics
2019
Abstract Background Distributed approaches based on the MapReduce programming paradigm have started to be proposed in the Bioinformatics domain, due to the large amount of data produced by the next-generation sequencing techniques. However, the use of MapReduce and related Big Data technologies and frameworks (e.g., Apache Hadoop and Spark) does not necessarily produce satisfactory results, in terms of both efficiency and effectiveness. We discuss how the development of distributed and Big Data management technologies has affected the analysis of large datasets of biological sequences. Moreover, we show how the choice of different parameter configurations and the careful engineering of the …
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with…
2020
Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation characteristics and their interplay with gastrointestinal physiology and biology. Physiological-based pharmacokinetic (PBPK) models integrate all available information on gastro-intestinal system with drug and formulation data to predict oral drug absorption. The latter together with in vitro-in vivo extrapolation and other preclinical data on drug disposition can be used to predict plasma concentration-time profiles in silico. Despite recent successes of PBPK in many areas of drug development, an improvement in their utility for evaluating oral absorption i…
Scalable Monitoring System for Clouds
2013
Although cloud computing has become an important topic over the last couple of years, the development of cloud-specific monitoring systems has been neglected. This is surprising considering their importance for metering services and, thus, being able to charge customers. In this paper we introduce a monitoring architecture that was developed and is currently implemented in the EASI-CLOUDS project. The demands on cloud monitoring systems are manifold. Regular checks of the SLAs and the precise billing of the resource usage, for instance, require the collection and converting of infrastructure readings in short intervals. To ensure the scalability of the whole cloud, the monitoring system mus…
dSDiVN: A Distributed Software-Defined Networking Architecture for Infrastructure-Less Vehicular Networks
2017
In the last few years, the emerging network architecture paradigm of Software-Defined Networking (SDN), has become one of the most important technology to manage large scale networks such as Vehicular Ad-hoc Networks (VANETs). Recently, several works have shown interest in the use of SDN paradigm in VANETs. SDN brings flexibility, scalability and management facility to current VANETs. However, almost all of proposed Software-Defined VANET (SDVN) architectures are infrastructure-based. This paper will focus on how to enable SDN in infrastructure-less vehicular environments. For this aim, we propose a novel distributed SDN-based architecture for uncovered infrastructure-less vehicular scenari…
Geographical Routing for Delay Tolerant Encounter Networks
2007
Delay Tolerant Networks (DTNs) are intermittently connected networks, where direct end--to--end path between communicating nodes may never exist. To achieve eventual delivery some nodes must store messages and wait opportunity to forward them. In mobile environment, one of the most challenging problems for routing protocols is to decide, which nodes should store the message to achieve eventual delivery as quick as possible. Common approach is to propagate message into large group of nodes, hoping one of them will reach the destination. These solutions, however, are not very scalable as they generate plenty of extra load and traffic to network. Further more, message carriers have no means to…
Random Slicing: Efficient and Scalable Data Placement for Large-Scale Storage Systems
2014
The ever-growing amount of data requires highly scalable storage solutions. The most flexible approach is to use storage pools that can be expanded and scaled down by adding or removing storage devices. To make this approach usable, it is necessary to provide a solution to locate data items in such a dynamic environment. This article presents and evaluates the Random Slicing strategy, which incorporates lessons learned from table-based, rule-based, and pseudo-randomized hashing strategies and is able to provide a simple and efficient strategy that scales up to handle exascale data. Random Slicing keeps a small table with information about previous storage system insert and remove operations…
Modeling and Simulation of Network-on-Chip Systems with DEVS and DEUS
2013
Networks on-chip (NoCs) provide enhanced performance, scalability, modularity, and design productivity as compared with previous communication architectures for VLSI systems on-chip (SoCs), such as buses and dedicated signal wires. Since the NoC design space is very large and high dimensional, evaluation methodologies rely heavily on analytical modeling and simulation. Unfortunately, there is no standard modeling framework. In this paper we illustrate how to design and evaluate NoCs by integrating the Discrete Event System Specification (DEVS) modeling framework and the simulation environment called DEUS. The advantage of such an approach is that both DEVS and DEUS support modularity—the fo…
Apple-products phytochemicals and processing: a review.
2009
Epidemiological studies have linked the consumption of apples with reduced risk of some cancers, cardiovascular disease, asthma, and diabetes. Extensive research exists on apples and the health benefits of their beverages and phytochemicals. The purpose of this paper is to review the most recent literature in this area focusing on phytochemicals, phytochemical bioavailability and antioxidant behavior.
Influence of different soluble dietary fibers on the bioaccessibility of the minor Fusarium mycotoxin beauvericin.
2011
Abstract Beauvericin (BEA) is a bioactive compound produced by the secondary metabolism of several Fusarium strains and is known to have various biological activities. This study investigated the bioaccessibility of the BEA tested in concentrations of 5 and 25 mg/L, in a model solution and in wheat crispy breads elaborated with different natural binding compounds as the soluble alimentary dietary fibers β-1,3 glucan, chitosan low molecular weight (L.M.W.), chitosan medium molecular weight (M.M.W.), fructooligosaccharides (FOS), galattomannan, inulin and pectin, added at concentrations of 1% and 5%. The bioaccessibility was determinated by employing a simulated gastrointestinal digestion tha…