Search results for "Lag"
showing 10 items of 3124 documents
OP0023 Targeted Polymeric Nanoparticles as Diagnostic and Therapeutic Tool for Rheumatoid Arthritis
2016
Background Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting joints due to the persistent synovial tissue inflammation. RA treatment has dramatically evolved in the last 20 years due to the production of biological Disease Modifying Antirheumatic Drugs (bDMARDs). However, side effects and the high costs of biological drugs are holding back their widespread usage. Moreover, some patients fail to respond to bDMARDs, for all of these reasons, DMARDs remains the main desired strategy for the treatment of RA, and Methotrexate (MTX) is still the “anchor” drug to treat RA. A successful treatment depends also on the early diagnosis, treating patients as soon as possible …
A Branch-and-Cut method for the Capacitated Location-Routing Problem
2011
International audience; Recent researches in the design of logistic networks have shown that the overall distribution cost may be excessive if routing decisions are ignored when locating depots. The Location-Routing Problem (LRP) overcomes this drawback by simultaneously tackling location and routing decisions. The aim of this paper is to propose an exact approach based on a Branch-and-Cut algorithm for solving the LRP with capacity constraints on depots and vehicles. The proposed method is based on a zero-one linear model strengthened by new families of valid inequalities. The computational evaluation on three sets of instances (34 instances in total), with 5–10 potential depots and 20–88 …
IL RUOLO DEL PATRIMONIO NEL PROGETTO URBANO MARSIGLIA E TUNISI, CITTÁ DEL MEDITERRANEO
La ricerca si occupa del rapporto tra le nuove modalità di trasformazione della città mediterranea e le nuove strategie di rigenerazione e valorizzazione del patrimonio materiale e immateriale. Comprendere qual è il ruolo del patrimonio nel processo di trasformazione e crescita della città mediterranea, attraverso la pratica del progetto urbano, è la questione principale della tesi, che si inserisce nel campo delle ricerche sulle modalità di trasformazione della città contemporanea. La ricerca si interroga, inoltre, su quale sia il rapporto che oggi lega il patrimonio e la sviluppo sostenibile, ambiti non più antitetici ma complementari, in una costruzione reciproca di simbologie e differen…
Carga global, regional y nacional de neurológicas. Desórdenes, 1990-2016: un análisis sistemático para el Global Estudio de la carga de enfermedad 20…
2019
Publisher´s version (útgefin grein).
Le phénomène de découplage dans les cliniques françaises
2013
Cet article propose d’expliquer le phénomène de découplage observé dans les établissements d’hospitalisation privé. En effet, nous avons remarqué, comme nombre d’études sur ce sujet, que des normes de Gestion des Ressources Humaines (GRH) construites par les agents institutionnels sont peu appliquées dans la réalité, sans provoquer de sanction. Pourquoi cette remise en question de ces normes est-elle acceptée, et par quels processus ? Le concept de découplage qui a été développé par les fondateurs du courant néo-institutionnaliste est utilisé pour expliquer ce phénomène. Pour ces auteurs, la conformité aux normes institutionnelles peut être de pure forme permettant à l’organisation d’obteni…
Le maillage territorial comme levier de la transition socio-écologique : Mise en récit d’expérimentations en Bourgogne Franche-Comté
2022
Ce document constitue une mise en récit du projet de recherche action participative Bourgogne-Franche-Comté (BFC) en transition coordonné par la Direction régionale de l’environnement, de l’aménagement et du logement BFC, la Maison des sciences de l’homme de Dijon, le Centre d’études et d’expertise sur les risques, l’environnement, la mobilité et l’aménagement, l’association Belfortaine In’Terre ActiV et l’expérimentation Territoire zéro chômeur de longue durée des Bertranges.Retrouvez également l'article scientifique :https://doi.org/10.4000/norois.12812
Effective Field Theory
2015
Effective field theories (EFTs) are a highly important topic in Quantum Field Theory. Here we are going to shortly present some important highlights as well as the renormalization group equations for the Wilson coefficients. Afterwards we shall focus on one illustrative example and present the \(\textit{matching}\) procedure at the one-loop level. The infrared behaviour of EFTs is also covered with this example.
EGFL7 ligates αvβ3 integrin to enhance vessel formation
2013
Angiogenesis, defined as blood vessel formation from a preexisting vasculature, is governed by multiple signal cascades including integrin receptors, in particular integrin αVβ3. Here we identify the endothelial cell (EC)-secreted factor epidermal growth factor-like protein 7 (EGFL7) as a novel specific ligand of integrin αVβ3, thus providing mechanistic insight into its proangiogenic actions in vitro and in vivo. Specifically, EGFL7 attaches to the extracellular matrix and by its interaction with integrin αVβ3 increases the motility of EC, which allows EC to move on a sticky underground during vessel remodeling. We provide evidence that the deregulation of EGFL7 in zebrafish embryos leads …
A peptide inhibiting the collagen binding function of integrin alpha2I domain.
1999
Integrin alpha2 subunit forms in the complex with the beta1 subunit a cell surface receptor binding extracellular matrix molecules, such as collagens and laminin-1. It is a receptor for echovirus-1, as well. Ligands are recognized by the special "inserted" domain (I domain) in the integrin alpha2 subunit. Venom from a pit viper, Bothrops jararaca, has been shown to inhibit the interaction of platelet alpha2beta1 integrin with collagen because of the action of a disintegrin/metalloproteinase named jararhagin. The finding that crude B. jararaca venom could prevent the binding of human recombinant ralpha2I domain to type I collagen led us to study jararhagin further. Synthetic peptides represe…
Discrepancies between archaeological and 14C-based chronologies: problems and possible solutions
2018
14C dating of bone collagen is believed to produce the most reliable absolute dates for the Central European Early Neolithic, as the selection of bones in anatomical context minimises taphonomic problems. In contrast, a comparison of three newly published local or regional chronological models as well as a comparison of several series of dates from bone collagen, charcoal and cereals highlights problems probably caused by diagenetic influences, especially on collagen. Therefore, at least the checking of bone collagen 14C dates against charcoal or cereal dates from the same contexts seems to be indispensable.