Search results for "Lait"

RAPTOR : A new collinear laser ionization spectroscopy and laser-radiofrequency double-resonance experiment at the IGISOL facility

2023

RAPTOR, Resonance ionization spectroscopy And Purification Traps for Optimized spectRoscopy, is a new collinear resonance ionization spectroscopy device constructed at the Ion Guide Isotope Separator On-Line (IGISOL) facility at the University of Jyv\"askyl\"a, Finland. By operating at beam energies of under 10 keV, the footprint of the experiment is reduced compared to more traditional collinear laser spectroscopy beamlines. In addition, RAPTOR is coupled to the JYFLTRAP Penning trap mass spectrometer, opening a window to laser-assisted nuclear-state selective purification, serving not only the mass measurement program, but also supporting post-trap decay spectroscopy experiments. Finally,…

Kuntoutusasiakkaiden asiakasprofiili ja heidän arvionsa palveluiden laadusta kuntoutuslaitoksessa : case Kylpylähotelli ja kuntoutus Peurunka

2013

Kuntoutus on hyvin ajankohtainen aihe Suomessa, ja sitä tutkitaan ja selvitetään hyvin paljon. Väestön ikääntyminen, ostopalveluihin siirtyminen sekä kuntoutuslaitosten rapistuminen tuovat kuntoutukseen omalta osaltaan uusia järjestelyitä tulevaisuudessa. Kuntoutuslaitoksissa käyvien kuntoutusasiakkaiden asiakasprofiilia ei ole aiemmin selvitetty. Tämän lisäksi on tärkeä selvittää heidän ajatuksiaan ja arviotaan palveluista ja niiden laadusta. Pro gradu - tutkielman tarkoituksena oli selvittää ja kuvata kuntoutusasiakkaiden asiakasprofiilia Kylpylähotelli ja kuntoutus Peurungassa sekä heidän arviotaan palveluiden laadusta. Tutkimus toteutettiin kyselytutkimuksena sekä teemahaastatteluin aik…

Multi-sited and historically layered language policy construction: parliamentary debate on the Finnish constitutional bilingualism in 1919

2018

In this article, we analyse the construction of Finnish constitutional bilingualism in the aftermath of gaining independence, a traumatic civil war and during the construction of a new republican polity based on regulated parliamentarism in 1917–1919. We take a multi-sited and historically informed approach to the dynamics of political discourse at the parliamentary level, analysing the discursive cycles of people, nationality and nation. We demonstrate the interconnectedness of language policy discourses with historically and spatially multi-sited and highly complex contexts and show how language policy confrontations can add important dimensions to increase our understanding of power stru…

A New Low Background Laboratory in the Pyhäsalmi Mine : Towards 14C free liquid scintillator for low energy neutrino experiments

2017

A new low background laboratory in Pyhäsalmi mine in the Central Finland has been put into operation in the beginning of 2017. The laboratory operates at the depth of 1436 m (~4100 meters of water equivalent). In this paper, we present description of the laboratory’s existing facility and background conditions. In the laboratory, a series of measurements has been started where the 14C concentration is determined from several liquid scintillator samples. A dedicated setup has been designed and constructed with the aim of measuring the 14C/12C ratio smaller than 10-18 . peerReviewed

Physico-chemical evolution of low-pH cements : influence of the temperature and the retention mechanisme of alkalins

2010

Because of their high alkalinity, Portland cement (OPC)-based materials may have deleterious effects in an underground waste repository. A solution would be to use low-alkalinity cements (also referred as low-pH cements) generating interstitial solutions with a reduced pH (11 instead of 13.5 for OPC), and thus showing an improved chemical compatibility with the repository environment. In this work, the investigated formulations were based on binary (OPC / silica fume) or ternary (OPC / silica fume / slag or fly ash) blends, with high substitution levels of CEM I (from 30% to 80%). This research project met two main objectives: (i) study the chemical evolution of low-pH cements at 50°C or 80…

Effects of mountain grassland maturity stage and grazing management on carotenoids in sward and cow's milk

2006

Carotenoids are involved in the sensorial and nutritional values of dairy products. In grazing systems, both herbage maturity stage and grazing management may affect the amount of carotenoid ingested, thus these factors may affect carotenoid concentrations in milk. Two homogenous plots of mountain grassland (1.4 and 2.0 ha) were grazed during two cycles of growth by 6 dairy cows in mid lactation, in strip (SG) and rotational grazing (RG), respectively. We monitored the changes in carotenoid concentrations in sward and milk, measured by HPLC twice a week. Seven carotenoids were identified in the sward: violaxanthin, antheraxanthin, epilutein, lutein, zeaxanthin, ß-carotene and 13-cis ß-carot…

Millaista tietoa aivokuvantamisella saadaan ja millaista ei?

2016

Mutation spectrum of NF1 gene in Italian patients with neurofibromatosis type 1 using Ion Torrent PGM™ platform

2017

Neurofibromatosis type 1 (NF1) is caused by mutations of the NF1 gene and is one of the most common human autosomal dominant disorders. The patient shows different signs on the skin and other organs from early childhood. The best known are six or more café au lait spots, axillary or inguinal freckling, increased risk of developing benign nerve sheath tumours and plexiform neurofibromas. Mutation detection is complex, due to the large gene size, the large variety of mutations and the presence of pseudogenes. Using Ion Torrent PGM™ Platform, 73 mutations were identified in 79 NF1 Italian patients, 51% of which turned out to be novel mutations. Pathogenic status of each variant was classifi…

SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia

2013

Constitutional dominant loss-of-function mutations in the SPRED1 gene cause a rare phenotype referred as neurofibromatosis type 1 (NF1)-like syndrome or Legius syndrome, consisted of multiple café-au-lait macules, axillary freckling, learning disabilities and macrocephaly. SPRED1 is a negative regulator of the RAS MAPK pathway and can interact with neurofibromin, the NF1 gene product. Individuals with NF1 have a higher risk of haematological malignancies. SPRED1 is highly expressed in haematopoietic cells and negatively regulates haematopoiesis. SPRED1 seemed to be a good candidate for leukaemia predisposition or transformation. We performed SPRED1 mutation screening and expression status i…

Learning to Eat Vegetables in Early Life: The Role of Timing, Age and Individual Eating Traits

2014

Vegetable intake is generally low among children, who appear to be especially fussy during the pre-school years. Repeated exposure is known to enhance intake of a novel vegetable in early life but individual differences in response to familiarisation have emerged from recent studies. In order to understand the factors which predict different responses to repeated exposure, data from the same experiment conducted in three groups of children from three countries (n = 332) aged 4-38 m (18.9 +/- 9.9 m) were combined and modelled. During the intervention period each child was given between 5 and 10 exposures to a novel vegetable (artichoke puree) in one of three versions (basic, sweet or added e…