Search results for "Lament"

Small GTP-binding proteins of the Rho- and Ras-subfamilies are not involved in the actin rearrangements induced by attaching and effacingEscherichia …

1998

Attaching and effacing Escherichia coli (AEEC) are extracellular pathogens that induce the formation of actin-rich structures at their sites of attachment to eukaryotic host cells. We analysed whether small GTP-binding proteins of the Rho- and Ras-subfamilies, which control the cellular actin system, are essential for these bacterial-induced microfilament reorganizations. For this purpose we specifically inactivated them using the Clostridium difficile toxins TcdB-10463 and TcdB-1470. Such treatment led to a dramatic breakdown of the normal actin cytoskeleton, but did not abrogate the bacterial-induced actin rearrangements. Our data therefore indicate that the microfilament reorganizations …

Polyelectrolyte properties of filamentous biopolymers and their consequences in biological fluids.

2014

Anionic polyelectrolyte filaments are common in biological cells. DNA, RNA, the cytoskeletal filaments F-actin, microtubules, and intermediate filaments, and polysaccharides such as hyaluronan that form the pericellular matrix all have large net negative charge densities distributed over their surfaces. Several filamentous viruses with diameters and stiffnesses similar to those of cytoskeletal polymers also have similar negative charge densities. Extracellular protein filaments such collagen, fibrin and elastin, in contrast, have notably smaller charge densities and do not behave as highly charged polyelectrolytes in solution. This review summarizes data that demonstrate generic counterion-…

Secondo Concorso per il Palazzo del Parlamento a Roma, area dei Mercati Traianei, 1888, Ernesto Basile

2014

SECONDO CONCORSO PER IL PALAZZO DEL PARLAMENTO, ROMA 1888-1889, ERNESTO BASILE Redatto tra la fine del 1888 e il 1889, in parte presso lo studio palermitano del padre e prevalentemente nel suo studio di Roma, il progetto presentato al II Concorso per il Palazzo del Parlamento del Regno d’Italia constava di sedici tavole di grandi dimensioni. Il corpus dei disegni (a matita, inchiostro di china e acquerello monocromo, con presenza di inchiostri colorati solamente per le indicazioni distributive e per le percorrenze veicolari) elencati e descritti nella memoria autografa allegata al progetto, e datata “Roma, 31 ottobre 1889”, comprendeva: una planimetria generale “con le adiacenze” in scala 1…

Music at San Martino delle Scale (Palermo) during the Renaissance period: the “Lamentationes ac Responsoria” for the Holy Week by Mauro Ciaula

Music at San Martino delle Scale (Palermo) during the Renaissance period: Mauro Ciaula and the book of ‘Lamentationes ac Responsoria’ for the Holy We…

Kryzys parlamentaryzmu a majowy zamach stanu w aspekcie bezpieczeństwa narodowego

2017

Demokracja parlamentarna nie jest typem ustroju, który może sprawnie i stabilnie funkcjonować bez solidnych podstaw ekonomicznych i społecznych, ugruntowanej i opartej na kompromisie tradycji uprawiania polityki oraz postaw obywatelskich pośród polityków i społeczeństwa. Porzucenie demokracji czyjej częściowe ograniczenie, aczkolwiek usprawiedliwione ideą racji stanu w celu wzmocnienia szeroko pojętego bezpieczeństwa narodowego, nie musi okazać się właściwym lekarstwem na problemy, z jakimi boryka się państwo. Kryzys parlamentaryzmu i przewrót majowy, zamykają okres, w którym sejm stanowił organ ostatecznie decydujący o składzie i istnieniu kolejnych rządów. Formalną zmianę we wzajemnym usy…

L'impacte d'Helene Deutsch: Psicologia de les dones, en l'àmbit feminista

2016

espanolEn este trabajo se ha analizado la obra de Helene Deutsch The psychology of women, con el objetivo de conocer su influencia en la Psicologia de la mujer. Asi por medio de una metodologia bibliometrica se ha elaborado una base de datos bibliograficos a partir del Social Sciences Citation Index (1956-2005). Los resultados indican que este libro ha sido citado un considerable numero de veces, lo cual muestra el impacto de la aproximacion psicoanalitica en el campo feminista. Los autores que mas lo citan pertenecen a aquella aproximacion psicoanalitica, a la Psicologia del desarrollo y al ambito feminista. Y entre las revistas, abundan las psicoanaliticas. Asimismo, los autores mas citad…

Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: Results of the randomized, double-blind, placebo-controll…

2009

High-density-lipoproteins-cholesterol (HDL-C) is invertedly related to the incidence of cardiovascular events. Recent studies suggest that HDL-C directly improves endothelial function. Nicotinic acid (niacin) effectively raises serum HDL-C. We therefore hypothesized that treatment with niacin improves endothelial dysfunction in patients with coronary artery disease (CAD). One hundred seven patients with CAD were randomly assigned to double-blinded treatment for 12 weeks with extended-release (ER)-niacin 1000 mg/day (N) or placebo (C), respectively. Flow-mediated dilation (FMD) of the brachial artery, nitroglycerin-mediated endothelium-independent dilation (NMD) and serum lipid concentration…

Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis

2012

The cyclic nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) regulate the activity of protein kinase A (PKA) and protein kinase G (PKG), respectively. This process helps maintain circulating platelets in a resting state. Here we studied the role of cAMP and cGMP in the regulation of megakaryocyte (MK) differentiation and platelet formation. Cultured, platelet-producing MKs were differentiated from fetal livers harvested from 13.5 days postcoital mouse embryos. MK development was accompanied by a dramatic increase in cAMP production and expression of soluble guanylate cyclase, PKG, and PKA as well as their downstream targets vasodilator-stimulated ph…

A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: Re…

2006

Clinical studies have demonstrated beneficial effects for clopidogrel in patients with atherothrombotic disease. Recent in vitro studies identified stimulating effects of clopidogrel on endothelial cells, pointing towards mechanisms of action beyond the inhibition of platelet aggregation. We hypothesized that in vivo use of clopidogrel improves endothelial dysfunction in patients with coronary artery disease (CAD). Fifty-eight patients with CAD were randomly assigned to double-blinded oral administration of one single dose of clopidogrel 300 mg (C300) or 600 mg (C600), respectively. Endothelial function was assessed by measurement of flow-mediated dilation (FMD) of the brachial artery befor…