Search results for "Large"
showing 10 items of 2197 documents
On Using the Theory of Regular Functions to Prove the ε-Optimality of the Continuous Pursuit Learning Automaton
2013
Published version of a chapter in the book: Recent Trends in Applied Artificial Intelligence. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-38577-3_27 There are various families of Learning Automata (LA) such as Fixed Structure, Variable Structure, Discretized etc. Informally, if the environment is stationary, their ε-optimality is defined as their ability to converge to the optimal action with an arbitrarily large probability, if the learning parameter is sufficiently small/large. Of these LA families, Estimator Algorithms (EAs) are certainly the fastest, and within this family, the set of Pursuit algorithms have been considered to be the pioneering schemes. The…
"Design and application of a data-independent precursor and product ion repository."
2012
The functional design and application of a data-independent LC-MS precursor and product ion repository for protein identification, quantification, and validation is conceptually described. The ion repository was constructed from the sequence search results of a broad range of discovery experiments investigating various tissue types of two closely related mammalian species. The relative high degree of similarity in protein complement, ion detection, and peptide and protein identification allows for the analysis of normalized precursor and product ion intensity values, as well as standardized retention times, creating a multidimensional/orthogonal queryable, qualitative, and quantitative spac…
Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC
2010
19 páginas, 2 figuras, 1 tabla.-- et al.(ATLAS Collaboration).
Measurement of visible cross sections in proton-lead collisions at √sNN= 5.02 TeV in van der Meer scans with the ALICE detector
2014
In 2013, the Large Hadron Collider provided proton-lead and lead-proton collisions at the center-of-mass energy per nucleon pair $\sqrt{s_{\rm{NN}}}=5.02$ TeV. Van der Meer scans were performed for both configurations of colliding beams, and the cross section was measured for two reference processes, based on particle detection by the T0 and V0 detectors, with pseudo-rapidity coverage $4.6<\eta< 4.9$, $-3.3<\eta<-3.0$ and $2.8<\eta< 5.1$, $-3.7<\eta<-1.7$, respectively. Given the asymmetric detector acceptance, the cross section was measured separately for the two configurations. The measured visible cross sections are used to calculate the integrated luminosity of the proton-lead and lead-…
Gemcitabine and cisplatin versus vinorelbine and cisplatin versus ifosfamide+gemcitabine followed by vinorelbine and cisplatin versus vinorelbine and…
2003
Abstract Purpose: we carried out a phase III randomized trial to compare vinorelbine–cisplatin regimen to gemcitabine–cisplatin regimen, and to a sequential administration of gemcitabine–ifosfamide followed by vinorelbine–cisplatin or the opposite sequence of vinorelbine–cisplatin followed by ifosfamide–gemcitabine according to the ‘worst drug rule’ hypothesis in patients with locally advanced unresectable stage IIIB or metastatic stage IV non-small cell lung cancer. The primary endpoint was survival parameters, while secondary endpoints included analysis of response rates and toxicity. Patients and methods: patients were randomized to receive: (a) gemcitabine 1000 mg/m2 on days 1, 8 and 15…
Current Practices in the Management of Pulmonary Ground-Glass Opacities: A Survey of SICT Members
2018
Background Several gray areas and controversies exist concerning the management of pulmonary ground-glass opacities (GGOs), and there is a lack of consensus among clinicians on this topic. One of the main aims of the Italian Society of Thoracic Surgery is to promote education and research, so we decided to perform a survey on this topic to estimate current trends in practice in a large sample of thoracic surgeons. Methods A total of 160 thoracic surgeons responded, namely, completed our questionnaire (response rate, 53%; 160 of 302). The survey was composed of 36 questions divided into six subsections: (1) demographic characteristics of the respondents; (2) terminology and taxonomy; (3) rad…
Synchronous Two Distinct Neuroendocrine Lung Cancer Lesions
2015
Synchroniczne nowotwory płuc są rzadką chorobą, a prezentowany przypadek to pierwszy opublikowany opis jednoczesnego wystąpienia dwóch pierwotnych neuroendokrynnych raków płuca zlokalizowanych w jednym płacie. Przedstawiono przypadek 55-letniej pacjentki z dwoma pierwotnymi, odrębnymi neuroendokrynnymi rakami płata górnego płuca prawego. Pacjentka została przyjęta na oddział chirurgii klatki piersiowej w celu diagnostyki dwóch cieni okrągłych płuca prawego (o średnicy 11 i 19 mm) uwidocznionych na zdjęciu RTG klatki piersiowej wykonanym trzy miesiące wcześniej. Przy przyjęciu pacjentka nie prezentowała żadnych objawów związanych ze zmianami w płucu. Dalsze badania obrazowe wykazały zmiennoś…
Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA
2018
Abstract: BACKGROUND: The impact of treating OSA on renal function decline is controversial. Previous studies usually included small samples and did not consider specific effects of different CPAP modalities. The aim of this study was to evaluate the respective influence of fixed and autoadjusting CPAP modes on estimated glomerular filtration rate (eGFR) in a large sample of patients derived from the prospective European Sleep Apnea Database cohort. METHODS: In patients of the European Sleep Apnea Database, eGFR prior to and after follow-up was calculated by using the Chronic Kidney Disease-Epidemiology Collaboration equation. Three study groups were investigated: untreated patients (n = 14…
Molecular determinants of large cargo transport into the nucleus
2020
Nucleocytoplasmic transport is tightly regulated by the nuclear pore complex (NPC). Among the thousands of molecules that cross the NPC, even very large (>15 nm) cargoes such as pathogens, mRNAs and pre-ribosomes can pass the NPC intact. For these cargoes, there is little quantitative understanding of the requirements for their nuclear import, especially the role of multivalent binding to transport receptors via nuclear localisation sequences (NLSs) and the effect of size on import efficiency. Here, we assayed nuclear import kinetics of 30 large cargo models based on four capsid-like particles in the size range of 17–36 nm, with tuneable numbers of up to 240 NLSs. We show that the requireme…
The High A(V) Quasar Survey: Reddened quasi-stellar objects selected from optical/near-infrared photometry - II
2014
Quasi-stellar objects (QSOs) whose spectral energy distributions (SEDs) are reddened by dust either in their host galaxies or in intervening absorber galaxies are to a large degree missed by optical color selection criteria like the one used by the Sloan Digital Sky Survey (SDSS). To overcome this bias against red QSOs, we employ a combined optical and near-infrared color selection. In this paper, we present a spectroscopic follow-up campaign of a sample of red candidate QSOs which were selected from the SDSS and the UKIRT Infrared Deep Sky Survey (UKIDSS). The spectroscopic data and SDSS/UKIDSS photometry are supplemented by mid-infrared photometry from the Wide-field Infrared Survey Explo…