Search results for "Leptin"

ADIPONECTIN, LEPTIN, RESISTIN LEVELS IN CYSTIC FIBROSIS ADOLESCENTS

2012

INTRODUCTION: Patients with Cystic Fibrosis, especially in adolescence, could develop endocrine and metabolic complications, related to nutritional state and chronic inflammation. They develop a progressive decrease in lean body mass correlated with the progression of lung disease. Adipose tissue is involved as well and adipocytokines are a possible link between malnutrition and long term complications. PATIENTS AND METHODS: In 24 Cystic Fibrosis adolescents we studied auxological, nutritional, glycometabolic, endocrine patterns, together with leptin, adiponectin and resistin levels. We selected patients not affected by diabetes, insulin resistance, malnutrition, acute inflammatory states s…

Adiponectin, resistin, leptin levels in paediatric patients with chronic renal insufficiency: relationships with clinical, auxological and endocrine …

2009

Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1α

2007

We reported previously that the obesity hormone leptin is overexpressed in breast cancer biopsies. Here, we investigated molecular mechanisms involved in this process, focusing on conditions that are associated with obesity, that is, hyperinsulinemia and induction of hypoxia. By using quantitative real-time PCR, immunofluorescent detection of proteins and enzyme-linked immunosorbent assays, we found that treatment of MCF-7 breast cancer cells with high doses of insulin or the hypoxia-mimetic agent CoCl2, or culturing the cells under hypoxic conditions significantly increased the expression of leptin mRNA and protein. Notably, the greatest leptin mRNA and protein expression were observed und…

Relationship among Body Composition, Adipocytokines, and Irisin on Exercise Capacity and Quality of Life in COPD: A Pilot Study

2022

Adipose tissue is an endocrine organ that interferes with the severity of chronic obstructive pulmonary disease (COPD). Although inflammatory markers, body composition, and nutritional status have a significant impact on pulmonary function, the real contribution of adipocytokines and myokines in COPD is still controversial. We aimed to evaluate the role played by the body composition, leptin, adiponectin, haptoglobin, and irisin on the functional exercise capacity, respiratory function, and quality of life (QoL) in COPD. In 25 COPD (20% GOLD-1; 60% GOLD-2; 20% GOLD-3) patients and 26 matched control subjects, we find that leptin, total adiponectin and haptoglobin are significantly increased…

The role of adiponectin and leptin in the treatment of ovarian cancer patients

2019

Wprowadzenie: Rak jajnika wykrywany jest najczęściej w zaawansowanym stadium choroby. Jego patogeneza nie jest w pełni poznana, ale przyjmuje się, że odpowiedzialna jest za to podatność organizmu oraz zaburzenia hormonalne. Stale badana jest również rola niektórych cytokin jako czynników predykcyjnych w procesie leczenia. Celem pracy było określenie zależności pomiędzy stężeniem adiponektyny i leptyny a stopniem zaawansowania choroby oraz odpowiedzią na stosowaną chemioterapię. Materiał i metody: Grupa badana składała się z 43 pacjentek leczonych systemowo z powodu raka jajnika. Po zakwalifikowaniu do leczenia pacjentki otrzymały chemioterapię: 5–7 cykli według schematu paklitaksel/karbopla…

Energy use, diapause behaviour and northern range expansion potential in the invasive Colorado potato beetle

2011

Summary 1. As organisms expand their range towards northern latitudes they will encounter selective factors like harsh winter conditions. The ability to cope with and adapt to harsh winters may depend on the variability and evolutionary potential of relevant traits. 2. One adaptation in insects is winter diapause. It is characterized by changes in physiology, behaviour or in both. Physiological changes include lowered metabolic rate that enhances survival by saving limited energy reserves during overwintering. Active behavioural changes like burrowing into the soil allow individuals to escape harsh conditions. 3. We examined variation in overwintering body mass, resting metabolic rate (CO2 …

Northward range expansion requires synchronization of both overwintering behaviour and physiology with photoperiod in the invasive Colorado potato be…

2014

Abstract. Photoperiodic phenological adaptations are prevalent in many organisms living in seasonal environments. As both photoperiod and growth season length change with latitude, species undergoing latitudinal range expansion often need to synchronize their life cycle with a changing photoperiod and growth season length. Since adaptive synchronization often involves a large number of time-consuming genetic changes, behavioural plasticity might be a faster way to adjust to novel conditions. We compared behavioural and physiological traits in overwintering (diapause) preparation in three latitudinally different European Colorado potato beetle (Leptinotarsa decemlineata) populations reared u…

Caracterización molecular del mecanismo de patogénesis de las toxinas Cry de Bacillus thuringiensis activas contra insectos coleópteros

2013

Los bioinsecticidas basados en Bacillus thuringiensis (Bt) constituyen una herramienta de gran valor para el control de plagas de insectos, ya que presentan una forma de aplicación muy específica e inocua para los usuarios y el medio ambiente. Entender, tanto el mecanismo de toxicidad de estos bioinsecticidas como la respuesta desencadenada en los insectos diana, tiene como objetivo proporcionar una base útil para el desarrollo de insecticidas mejorados dirigidos contra estas importantes plagas agrícolas, permitiendo ampliar el rango y los niveles de toxicidad de las proteínas insecticidas y abordar problemas como la aparición de resistencia. La presente tesis se ha centrado en el estudio d…

The voyage of an invasive species across continents: genetic diversity of North American and European Colorado potato beetle populations

2005

The paradox of successful invading species is that they are likely to be genetically depauperate compared to their source population. This study on Colorado potato beetles is one of the few studies of the genetic consequences of continent-scale invasion in an insect pest. Understanding gene flow, population structure and the potential for rapid evolution in native and invasive populations offers insights both into the dynamics of small populations that become successful invaders and for their management as pests. We used this approach to investigate the invasion of the Colorado potato beetle (Leptinotarsa decemlineata) from North America to Europe. The beetles invaded Europe at the beginnin…

Responses in metabolic rate to changes in temperature in diapausing Colorado potato beetleLeptinotarsa decemlineatafrom three European populations

2015

Many insects survive adverse periods in seasonal environments by entering diapause, a deep resting stage, during which energy consumption is typically low and gas exchange is in the form of a discontinuous gas exchange cycle (DGC). Because insects in high-latitude environments are severely time constrained during summer, an effective diapause termination with careful regulation of metabolic rate is important. The present study examines whether diapausing Colorado potato beetles Leptinotarsa decemlineataSay originating from three latitudinally different regions in Europe differ in their quantitative or qualitative gas exchange patterns in response to an increasing temperature. Overall produc…