Search results for "Leukaemia"
showing 10 items of 65 documents
Exposure to benzene and childhood leukaemia: a pilot case-control study
2013
Objectives Main purpose To evaluate the feasibility of a measurement-based assessment of benzene exposure in case-control studies of paediatric cancer; Additional aims To identify the sources of exposure variability; to assess the performance of two benzene biomarkers; to verify the occurrence of participation bias; to check whether exposures to benzene and to 50 Hz magnetic fields were correlated, and might exert reciprocal confounding effects. Design Pilot case-control study of childhood leukaemia and exposure to benzene assessed by repeated seasonal weekly measurements in breathing zone air samples and outside the children9s dwellings, with concurrent determinations of cotinine, t-t-muco…
Das Chlorom (Granulozytäres Sarkom, Myeloblastom) - Klinik und radiologische Diagnostik -
2000
Six cases of granulocytic sarcoma are presented. A mediastinal chloroma and a tumor of the submandibular gland were observed with two patients as single sign of acute myeloic leukaemia. In one patient a chloroma appeared as first manifestation of acute myeloic leukaemia. Two patients exhibited the tumor as first symptom of a blastic crisis of chronic myelogenous leukaemia (femoral bone, lumbar spine). The sixth patient with a myelodyplastic syndrom showed a chloroma of the breast. Various radiological procedures were applied including plain radiography, MRT, CT and mammography. The results are compared with literature. Principles of therapy were supplemented.
Pulmonary hypertension associated with ponatinib therapy
2016
IF 8.332; International audience; A case of pulmonary hypertension associated with ponatinib therapy in a chronic myelogenous leukaemia patient.
Chronic myeloid leukaemia- derived exosomes promote tumour growth and survival through an autocrine mechanism
2014
USE OF CELL POSITIONAL DATA AND MULTIPARAMETER FLOW CYTOMETRY TO IDENTIFY B CELL CHRONIC LYMPHOCYTIC LEUKAEMIA
2013
Genetic variation in human leukocyte antigen and susceptibility to acute myeloid leukemia.
2015
In this issue of Acta Haematologica, Authors report the association between the Human Major Histocompatibility complex (MHC) HLA-C3 and Acute Myeloid Leukemia (AML) in Korean population, confirming previous studies on association between HLA-C and AML.
Chronic myelogenous leukaemia- derived exosomes mediate autocrine and paracrine interplays within the tumour microenvironment: a role for IL8
2014
La Leucemia Mieloide Cronica (LMC) è una neoplasia ematologica causata dalla traslocazione reciproca t(9:22) con conseguente formazione dell'oncoproteina BCR-ABL con attività tirosin-chinasica costitutiva. L’Imatinib mesilato (IM) è un inibitore selettivo dell’oncoproteina che ha migliorato significativamente la prognosi dei pazienti affetti da LMC. Nonostante il successo terapeutico, un grave problema connesso con la somministrazione di imatinib è lo sviluppo di resistenza farmacologica. E’ quindi necessario lo sviluppo di nuovi agenti antineoplastici che abbiano come target non soltanto le cellule tumorali ma anche il microambiente che le circonda. Recentemente, infatti, l’attenzione dei …
A comparison of some simple methods to identify geographical areas with excess incidence of a rare disease such as childhood leukaemia
1999
SUMMARY Six statistics are compared in a simulation study for their ability to identify geographical areas with a known excess incidence of a rare disease. The statistics are the standardized incidence ratio, the empirical Bayes method of Clayton and Kaldor, Poisson probability, a statistic based on the B statistics are compared for the proportion of true high-risk areas identi"ed in the top 1 per cent and 10 per cent of ranked areas. One of the PW statistics performed consistently well under all circumstances, although the results for the BT statistic were marginally better when only the top 1 per cent of ranked areas was considered. The standardized incidence ratio performed consistently …
Association between Serum Heat Shock Proteins and Gamma-Delta T Cells—An Outdated Clue or a New Direction in Searching for an Anticancer Strategy? A …
2021
HSPs demonstrate a strong association with gamma-delta (γδ) T cells. Most of the studies regarding interactions between the parameters were conducted in the 1990s. Despite promising results, the concept of targeting γδ T cells by HSPs seems to be a forgotten direction due to potent non-peptidic phosphoantigens rather than HSPs have been found to be the essential stimulatory components for human γδ cells. Currently, with greater knowledge of lymphocyte diversity, and more accurate diagnostic methods, we decided to study the correlation once again in the neoplastic condition. Twenty-one children with newly diagnosed acute lymphoblastic leukaemia (ALL) were enrolled on the study. Serum HSP90 c…