Search results for "Ley"
showing 10 items of 1218 documents
La doncella, el dragón y el brazo santo: mito y milagros de una reliquia de San Juan hallada en Constantinopla por los viajeros de la Embajada a Tamo…
2019
El año 1403, los viajeros de la llamada Embajada a Tamorlán, una de las principales empresas diplomáticas medievales de contacto de un reino europeo con el imperio mongol, recalaron en Constantinopla. En el monasterio de Santa María Períbleptos, les mostraron la reliquia del brazo y mano derecha de san Juan Bautista. La ausencia de un dedo en la mano de la reliquia es justificada en el texto a través de una leyenda que se les cuenta a los embajadores, en la que intervienen un dragón arrasador de un reino y la salvación de una doncella que tenía que ser ofrecida en sacrificio, leyenda semejante a la bien conocida de san Jorge y a las de otros santos protectores. Sin embargo, la leyenda conta…
Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation
2013
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast proliferation. Transition of epithelial/mesothelial cells into myofibroblasts [epithelial-to-mesenchymal transition (EMT)] occurs under the influence of transforming growth factor (TGF)-β1, with Snail being a major transcription factor. We study here the role of the heat-shock protein HSP27 in fibrogenesis and EMT. In vitro, we have up- and down-modulated HSP27 expression in mesothelial and epithelial cell lines and studied the expression of different EMT markers induced by TGF-β1. In vivo, we inhibited HSP27 with the antisense oligonucleotide OGX-427 (in phase II clinical trials as anticancer agent)…
'TRPing' synaptic ribbon function in the rat pineal gland: neuroendocrine regulation involves the capsaicin receptor TRPV1.
2009
Synaptic ribbons (SRs) are presynaptic structures thought to regulate and facilitate multivesicular release. In the pineal gland, they display a circadian rhythm with higher levels at night paralleling melatonin synthesis. To gain more insight into the processes involved and the possible functions of these structures, a series of experiments were conducted in rodents. We studied the regional distribution of a molecular marker of pineal SRs, the kinesin motor KIF3A in the gland. Respective immunoreactivity was abundant in central regions of the gland where sympathetic fibers were less dense, and vice versa, revealing that intercellular communication between adjacent pinealocytes is enhanced …
Arylalkylamine N-acetyltransferase gene expression in retina and pineal gland of rats under various photoperiods
2004
Abstract The present study examines how the circadian oscillators in the retina and the suprachiasmatic nucleus (SCN) respond to changes in photoperiod. ArylalkylamineN-acetyltransferase (aa-nat) gene expression studied by quantitative RT-PCR revealed that in adult Sprague–Dawley rats kept under different light–dark (LD) cycles for two weeks the temporal pattern of AA-NAT mRNA expression was identical in retina and pineal gland. In both tissues, the time span between the onset of darkness and the nocturnal rise in AA-NAT mRNA expression was 3 h under LD 20:4, 6 h under LD 12:12, and 15 h under LD 4:20. As aa-nat expression in the pineal gland is regulated by the circadian oscillator in SCN,…
Clinical and metabolic findings in a 6-year-old boy with a Leydig cell tumour
2011
Aim: To analyse the urinary steroid metabolome in a boy who had true precocious puberty after a Leydig cell tumour. Method: Case report and detailed description of clinical and metabolic findings in a 7-year-old-boy with a Leydig cell tumour. Results: Before surgery, the urinary steroid metabolome showed an activation of an alternative route to gonadal androgens independent of dehydroepiandrosterone (DHEA). After surgery, the boy entered true precocious puberty. Under leuprolide acetate treatment, clinical and laboratory findings normalized. Conclusion: Central precocious puberty after precocious pseudopuberty may be more common than expected and should be considered in children with pe…
Aligned microcontact printing of biomolecules on microelectronic device surfaces
2001
Microcontact printing (/spl mu/CP) of extracellular matrix proteins is a fascinating approach to control cell positioning and outgrowth, which is essential in the development of applications ranging from cellular biosensors to tissue engineering. Microelectronic devices can be used to detect the activity from a large number of recording sites over the long term. However, signals from cells can only be recorded at small sensitive spots. Here, the authors present an innovative setup to perform aligned /spl mu/CP of extracellular matrix proteins on microelectronic devices in order to guide the growth of electrogenic cells specifically to these sensitive spots. The authors' system is based on t…
L'évolution de l'occupation humaine : l'analyse spatiale exploratoire des données.Le problème de l'incertitude et de l'hétérogénéité des données en a…
2011
The analysis of the evolution of the settlement requires a lot of methodological questioning. Despite a frequent use of the spatial analysis methods, few works return to their methodological problems. This article proposes to make a comparison and a discussion around two exploratory statistical methods (the K function of Ripley and the Kernel Density Estimation). It seems that scale, quality and quantity of input data, are three essential parameters to be taken into account so as to lead a spatial analysis in archaeology. In intrinsic way, archaeological data are non homogeneous. For that purpose, our article proposes a multi scalar approach integrating the non homogeneousness character of …
Les sites du lit mineur de la Saône en Chalonnais (Saône-et Loire) à la fin du Bronze final
2017
The underwater archaeological campaigns carried out over twenty years, from 1970 to 1990, in the Saône valley, more particularly in the area of Chalon-sur-Saône, first by Louis Bonnamour and then by Annie Dumont, generated a considerable quantity of data concerning settlements, located on fjords or river banks. This documentation, stored at the Musée Denon in Chalon-sur-Saône, was the subject of new studies, initiated by Jean-Michel Treffort for the Ouroux-sur-Saône “Marnay” site and continued by Franck Ducreux, notably for the Chalon-sur-Saône “le gué des Piles” site. On this occasion most of the sites of the region having yielded protohistoric assemblages were reconsidered. This article p…
Consideraciones sobre la formación inicial del profesorado en educación para la salud
1993
Expone como elaborar y poner en práctica un programa de educación para la salud. Se debe saber adaptar el currículo oficial, y desarrollar una programación concreta de aula. Todo ello significa conocer la naturaleza del proceso de enseñanza-aprendizaje: conocimientos, creencias actitudes, escalas del alumnado. Nos habla del concepto de salud y sus determinantes, de la educación para la salud, de los objetivos de la educación para la salud en la escuela y una propuesta de formación inicial en educación para la salud. Estos aspectos deben de contemplar: los contenidos que desarrollen los conceptos de salud, la metodología de trabajo, los problemas que presenta la interiorización de los temas …
Physical or cultural frontier: a question of method. The example of the Imera-Salso sicilian valley
2009
Facing the study of the frontier on the basis of archaeological evidence presupposes the construction of a rigorous methodological grid which acts as an interpretative filter of the evidence to be analysed. From the 1970s to the present, frontier studies have undergone a notable increase. The debate on the subject has expanded, directing research on several levels. This contribution proposes a model of analysis of the numismatic and archaeological documentation aimed at studying the frontier of the Imera-Salso valley in Sicily