Search results for "Ley"
showing 10 items of 1218 documents
Digestive vacuole of Plasmodium falciparum released during erythrocyte rupture dually activates complement and coagulation.
2012
Abstract Severe Plasmodium falciparum malaria evolves through the interplay among capillary sequestration of parasitized erythrocytes, deregulated inflammatory responses, and hemostasis dysfunction. After rupture, each parasitized erythrocyte releases not only infective merozoites, but also the digestive vacuole (DV), a membrane-bounded organelle containing the malaria pigment hemozoin. In the present study, we report that the intact organelle, but not isolated hemozoin, dually activates the alternative complement and the intrinsic clotting pathway. Procoagulant activity is destroyed by phospholipase C treatment, indicating a critical role of phospholipid head groups exposed at the DV surfa…
Mind the Gap: The Big House in Cinematic Representations of the Anglo-Irish War
2018
It goes without saying that the Big House was intended to be a symbol: as more than one critic has remarked, these houses really were only “big” in comparison to the poverty of the lesser structures that surrounded them. They were to be a bastion for British and Anglo-Irish culture and a center for social and administrative interactions. In this sense, they straddled the gap between the towns of Dublin and London, whence their power came, and the villages to whom they administered: it is no coincidence that these garrisons of British power bore the brunt of Republican anger during the Troubles of 1919-1921. Examining two of the rare films to focus on the War of Independence from the perspec…
De los fueros locales al fuero de Valencia en el marco del proceso de instauración de la sociedad feudal del siglo XIII en el reino de Valencia
2017
This paper analyzes the process of changing local laws (fueros) to a territorial law (fuero) in the context of the new kingdom of Valencia created in 1240 by King James I. Following the tradition of Catalonia and Aragon, also in Valencia the crown and nobility initially organized the repopulation based on different local fueros: Sepúlveda, Zaragoza, Daroca, Teruel, Fontana, costum de Lleida or costum/fuero of Valencia. But from 1245, the monarchy drove the territorial law (fuero) of Valencia, which has traditionally been interpreted as a political reason for confrontation between Catalan and Aragonese populators. Our study explains how the Fuero of Zaragoza/Aragon was limited during the 13t…
X4 : luovia tuulia maailmalta
2012
Kaupunkipostikorttisarja
Homenatge a Stanley L. Miller
2003
Conferència homenatge al professor Stanley L. Miller.
Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats
2007
As an endogenous agonist at the cannabinoid receptor CB1 and the capsaicin-receptor TRPV1, anandamide may exert both anti- and pronociceptive actions. Therefore we studied the effects of anandamide and other activators of both receptors on changes in free cytosolic calcium ([Ca2+]i) in acutely dissociated small dorsal root ganglion neurons (diameter: ≤30 μm). Anandamide (10 μM) increased [Ca2+]iin 76% of the neurons. The EC50was 7.41 μM, the Hill slope was 2.15 ± 0.43 (mean ± SE). This increase was blocked by the competitive TRPV1-antagonist capsazepine (10 μM) and in Ca2+-free extracellular solution. Neither exclusion of voltage-gated sodium channels nor additional blockade of voltage-gate…
Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons.
1997
Noxious heat is able to activate heat-sensitive nociceptors in the skin very rapidly, but little is known about the mechanisms by which heat is transduced. We used the whole-cell patch-clamp technique to study the effects of noxious heat and capsaicin on freshly dissociated rat dorsal root ganglion neurons in vitro. Using temperatures between 41 degrees C and 53 degrees C, 8 of 19 small neurons (phior = 30 microm) exhibited a heat-evoked inward current. All heat-sensitive neurons tested were also capsaicin-sensitive. Moreover, the heat response tended to be enhanced after capsaicin (360 +/- 150 pA versus 125 +/- 45 pA, P0.1, n = 7). Two of five heat-insensitive neurons were excited by capsa…
Derecho natural y derechos humanos: síntesis práctica y complementariedad teórica
1998
En este artículo se argumentan los siguientes puntos: 1. El lenguaje de los derechos humanos surge en Occidente en sintonía con la subjetivización de la idea de derecho iniciada a finales de la Edad Media. En ello se advierte sin dificultad la diferencia existente entre las modernas declaraciones de derechos humanos, y la doctrina clásica del derecho natural, que era una doctrina eminentemente práctica, integrada en la virtud de la justicia 2. Una fundamentación consistente de los derechos humanos en la idea de dignidad debe remitir necesariamente bien a un plano trascendental bien a un plano ontológico. Por su parte, el esclarecimiento de la idea de dignidad permite profundizar en la natur…
Sediment origin and pedogenesis in the former mill pond basin of Turznice (north-central Poland) based on magnetic susceptibility measurements
2016
Abstract This paper aims to assess the usefulness of magnetic susceptibility measurements in pedological studies of mill pond sediments. The study area includes the former Turznice mill pond basin located in the south-eastern part of the Grudziądz Basin. Four soil profiles were selected within the transect located along the longitudinal axis of the basin. The following soil properties were determined in the collected samples: bulk density, particle size distribution, pH, content of carbonates, approximate content of organic matter (LOI), total organic carbon (TOC), total nitrogen (Nt), and the pseudo-total contents of metals (Fe, Mn, Cu, Zn, Pb, Ni, Cd). The obtained results were correlated…