Search results for "Lici"
showing 10 items of 2919 documents
X-Linked Dilated Cardiomyopathy.
1995
We report on a family with a severe form of X-linked dilated cardiomyopathy (DCM). Two brothers, the elder requiring heart transplantation, and a maternal cousin presented elevated creatine kinase levels, increased right ventricular diameters and electrocardiographic abnormalities. All complained of exertional cramping myalgia, but none had muscle weakness or a pathological electromyogram. Muscle biopsies of these individuals revealed a mild myopathic picture with atrophic type I and hypertrophic type II fibers. Immunofluorescence using N- and C-terminal antibodies (dys-2, dys-3) against the dystrophin protein showed preserved, but reduced intensity of staining of the sarcolemmal membranes.…
Implicit Theories of Child Sexual Exploitation Material Offenders: Cross-Cultural Validation of Interview Findings
2019
Offense-supportive cognitions are thought to result from underlying implicit theories (ITs). As child sexual exploitation material (CSEM) users are a distinct type of sex offender, Bartels and Merdian proposed that CSEM offenders hold five different ITs from those endorsed by contact sex offenders (i.e., Unhappy World, Self as Uncontrollable, Child as Sexual Object, Nature of Harm [CSEM variant], and Self as Collector), linked by an assumption about the Reinforcing Nature of the Internet. This article reports a conceptual content analysis of 23 interviews conducted with CSEM offenders in the United Kingdom and Spain. Support for all CSEM-specific ITs was found across both samples, providing…
The autoantigen La/SS-B: Analysis of the expression of alternatively spliced La mRNA isoforms
1996
The gene for the nuclear autoantigen La/SS-B encodes two La mRNA isoforms. In order to study the function and expression of both La mRNA forms, an in situ hybridization procedure was developed allowing the selective identification of either exon 1 or exon 1'. For this purpose, digoxigenin-labeled exon-specific sense and anti-sense probes were prepared by in vitro transcription from plasmids that contained the respective exon sequence. Detection of the probes was carried out by using rhodamine-conjugated anti-digoxigenin antibody and confocal laser scanning microscopy. Both La mRNAs were found in the cytoplasm of endothelial cells but not in smooth muscle cells. In addition to the in situ te…
Disturbed brain activation during a working memory task in drug-naive adult patients with ADHD.
2010
Neuroimaging studies in attention-deficit/hyperactivity disorder (ADHD) have shown abnormalities in several brain areas including the frontostriatal circuitry and were mostly conducted in children and adolescents. We investigated 30 never-medicated adult ADHD patients (16 males) and 30 matched healthy control individuals. Functional magnetic resonance imaging was acquired during a working memory paradigm (n-back). Group activation maps and group differences of activation were calculated using voxel-based analyses. The generic activation pattern was more extended in the control group. In ADHD patients, significantly decreased activation was found in the right inferior parietal cortex. Distur…
Socioeconomic inequalities in the impact of tobacco control policies on adolescent smoking. A multilevel study in 29 European countries
2016
Abstract Introduction There are concerns that tobacco control policies may be less effective in reducing smoking among disadvantaged socioeconomic groups and thus may contribute to inequalities in adolescent smoking. This study examines how the association between tobacco control policies and smoking of 15-year-old boys and girls among 29 European countries varies according to socioeconomic group. Methods Data were used from the Health Behaviour in School-aged Children (HBSC) study conducted in 2005/2006 comprising 50,338 adolescents aged 15 years from 29 European countries. Multilevel logistic regression analyses were conducted to assess the association of weekly smoking with components of…
Implicit versus explicit attitude to doping: which better predicts athletes’ vigilance towards unintentional doping?
2018
Abstract Objectives This preliminary study examined whether implicit doping attitude, explicit doping attitude, or both, predicted athletes’ vigilance towards unintentional doping. Design A cross-sectional correlational design. Methods Australian athletes (N = 143; Mage = 18.13, SD = 4.63) completed measures of implicit doping attitude (brief single-category implicit association test), explicit doping attitude (Performance Enhancement Attitude Scale), avoidance of unintentional doping (Self-Reported Treatment Adherence Scale), and behavioural vigilance task of unintentional doping (reading the ingredients of an unfamiliar food product). Results Positive implicit doping attitude and explicit…
The Influence of University Students’ Stress Mindsets on Health and Performance Outcomes
2018
Background Emerging evidence indicates that holding particular stress mindsets has favorable implications for peoples’ health and performance under stress. Purpose The aim of the current study was to examine the processes by which implicit and explicit stress mindsets relate to health- and performance-related outcomes. Specifically, we propose a stress beliefs model in which somatic responses to stress and coping behaviors mediate the effect of stress mindsets on outcomes. Methods Undergraduate university students (N = 218, n = 144 females) aged 17– 25 years completed measures of stress mindset, physical and psychological wellbeing, perceived stress, perceived somatic responses to stress…
Structural priming is supported by different components of nondeclarative memory: Evidence from priming across the lifespan
2017
Abstract Structural priming is the tendency to repeat syntactic structure across sentences and can be divided into short-term (prime to immediately following target) and long-term (across an experimental session) components. Current theories of structural priming propose that different memory systems support these components, however, this study investigates how non-declarative memory could support both the transient, short-term and the persistent, long-term structural priming effects commonly seen in the literature. We propose that these characteristics are supported by different subcomponents of non-declarative memory: Perceptual and conceptual non-declarative memory respectively. Previou…
Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study …
2022
Background: The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year. Methods: For this analysis, we constructed burden-weighted dose-response relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and …
Oligophrenin 1 mutations frequently cause X-linked mental retardation with cerebellar hypoplasia
2005
Background: Mutations of oligophrenin 1, one of the first genes identified in nonspecific X-linked mental retardation (MRX), have been described in patients with moderate to severe cognitive impairment and predominant cerebellar hypoplasia, in the vermis. Objective: To further delineate the phenotypic and mutational spectrum of the syndrome, by screening oligophrenin 1 in two cohorts of male patients with mental retardation (MR) with or without known posterior fossa anomalies. Methods: Clinical examination, cognitive testing, MRI studies, and mutational analysis (denaturing gradient gel electrophoresis and direct sequencing) on blood lymphocytes were performed in 213 unrelated affected indi…